Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Neil K. Gibbs"'
A potential role for endogenous proteins as sacrificial sunscreens and antioxidants in human tissues
Autor:
Sarah A. Hibbert, Rachel E.B. Watson, Neil K. Gibbs, Patrick Costello, Clair Baldock, Anthony S. Weiss, Christopher E.M. Griffiths, Michael J. Sherratt
Publikováno v:
Redox Biology, Vol 5, Iss , Pp 101-113 (2015)
Excessive ultraviolet radiation (UVR) exposure of the skin is associated with adverse clinical outcomes. Although both exogenous sunscreens and endogenous tissue components (including melanins and tryptophan-derived compounds) reduce UVR penetration,
Externí odkaz:
https://doaj.org/article/5a7c4ff956604567b22d9610d0628bcc
Autor:
Suzanne M. Pilkington, Peter S. Friedmann, Neil K. Gibbs, Lesley E. Rhodes, Karen A. Massey, Anna Nicolaou, S Bennett, Patrick Costello
Publikováno v:
Pilkington, S, Gibbs, N, Costello, P, Bennett, S, Massey, K A, Friedmann, P S, Nicolaou, A & Rhodes, L 2016, ' Effect of oral eicosapentaenoic acid on epidermal Langerhans cell numbers and PGD2 production in UVR-exposed human skin: a randomised controlled study ', Experimental Dermatology . https://doi.org/10.1111/exd.13177
Langerhans cells (LCs) are sentinels of skin's immune system, their loss from epidermis contributing to UVR suppression of cell-mediated immunity (CMI). Omega-3 polyunsaturated fatty acids show potential to reduce UVR suppression of CMI in mice and h
Publikováno v:
Photodermatology, Photoimmunology & Photomedicine. 30:112-127
Skin cancer is a major public health concern, and the primary aetiological factor in the majority of skin cancers is ultraviolet radiation (UVR) exposure. UVR not only induces potentially mutagenic DNA damage but also suppresses cell-mediated immunit
Autor:
Neil K. Gibbs, Mary Norval
Publikováno v:
Photodermatology, Photoimmunology & Photomedicine. 29:57-64
Exposure to ultraviolet radiation can lead to suppression of many adaptive immune responses, both to antigens encountered within a short period of the irradiation (primary) and to antigens previously encountered (memory). The pathways involved are co
Autor:
Joachim Kreysa, Mara Ceridono, Eckhard Heisler, Valérie Zuang, João Barroso, Anthony M. Lynch, Mick D. Fellows, David Jones, Catherine Robles, J. Frank Nash, Jacqueline K Akunda, Neil K. Gibbs, Peter Kasper, Cyrille Krul, Abigail Jacobs, Hans Werner Vohr, Dagmar Jírová, Helena Kandarova, Kazuichi Nakamura, Douglas C. Bauer, Nathalie Alépée, Femke M. van de Water, Uwe Pfannenbecker, Olivier Wattrelos, Ann De Smedt, Wolfgang Muster, Gareth Phillips, Douglas B. Learn, Vera Rogiers, Ulla Wändel Liminga, Julie A. Woods, Raffaella Corvi, Manfred Liebsch, Phil Wilcox, Pär Tellner
Publikováno v:
Regulatory Toxicology and Pharmacology, June, 3, 63, 480-488
This is the report from the “ECVAM–EFPIA workshop on 3T3 NRU Phototoxicity Test: Practical Experience and Implications for Phototoxicity Testing”, jointly organized by ECVAM and EFPIA and held on the 25–27 October 2010 in Somma Lombardo, Ital
Low-dose ultraviolet radiation selectively degrades chromophore-rich extracellular matrix components
Autor:
Siobhan M Reilly, Michael J. Sherratt, Rachel E.B. Watson, Neil K. Gibbs, Christopher P Bayley, Christopher E.M. Griffiths
Publikováno v:
The Journal of Pathology. 222:32-40
Photoageing of human skin due to chronic exposure to ultraviolet radiation (UVR) is characterized histologically by extensive remodelling of the dermal elastic fibre system. Whilst enzymatic pathways are thought to play a major role in mediating extr
Publikováno v:
Photodermatology, Photoimmunology & Photomedicine. 22:297-303
BACKGROUND: Ultraviolet (UV) radiation damages the cellular DNA of skin cells. In response, wild-type p53 protein accumulates in irradiated cells and the stabilized and transactivated protein can then induce genes involved in cell cycle arrest in G1,
Autor:
Neil K. Gibbs, Angelique Fluitman, Mary Norval, Pauline McLoone, I. Man, H. van Loveren, Steven Yule
Publikováno v:
Photodermatology Photoimmunology & Photomedicine, 20(2), 76-80. Blackwell Munksgaard
BACKGROUND/PURPOSE: Ultraviolet (UV) exposure of mammalian skin induces local and systemic immunosuppression. In mice it has been proposed that systemic immunosuppression is mediated by an UV-induced cytokine cascade involving systemic interleukin (I
Publikováno v:
Photodermatology, Photoimmunology & Photomedicine. 19:217-227
Polymorphic light eruption (PLE) is a highly prevalent photosensitivity disorder, estimated to affect 11-21% people in temperate countries. Typically, PLE appears as a recurrent pruritic eruption comprising papules and/or vesicles and/or plaques, whi
Autor:
Mary Norval, Neil K. Gibbs
Publikováno v:
Photodermatology, Photoimmunology & Photomedicine. 26:112-114