Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Medha Priyadarshini"'
Autor:
Md. Wasim Khan, Alexander R. Terry, Medha Priyadarshini, Vladimir Ilievski, Zeenat Farooq, Grace Guzman, Jose Cordoba-Chacon, Issam Ben-Sahra, Barton Wicksteed, Brian T. Layden
Publikováno v:
Cell Death and Disease, Vol 13, Iss 7, Pp 1-17 (2022)
Mitochondrial interaction of HKDC1 is essential for its pro-proliferative role in LC. When HKDC1 is ablated in liver cancer cells, mitochondrial dysfunction occurs which results in decrease ATP in the cells. The cancer cells react to decreased cellul
Externí odkaz:
https://doaj.org/article/7091df137c6f4bf0aaa04fb1d39d604d
Autor:
Sirimon Reutrakul, Pamela Martyn-Nemeth, Lauretta Quinn, Brett Rydzon, Medha Priyadarshini, Kirstie K. Danielson, Kelly G. Baron, Jennifer Duffecy
Publikováno v:
Pilot and Feasibility Studies, Vol 8, Iss 1, Pp 1-9 (2022)
Abstract Objectives Women with a history of gestational diabetes (GDM) are at 7-fold increase in the risk of developing diabetes. Insufficient sleep has also been shown to increase diabetes risk. This study aimed to explore the feasibility of a sleep
Externí odkaz:
https://doaj.org/article/1a94e109c86a43708df8d81a57ccf151
Autor:
Raza Ali Naqvi, Afsar Raza Naqvi, Amar Singh, Medha Priyadarshini, Appakalai N. Balamurugan, Brian T. Layden
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2023)
Replacement of β cells is only a curative approach for type 1 diabetes (T1D) patients to avoid the threat of iatrogenic hypoglycemia. In this pursuit, islet allotransplantation under Edmonton’s protocol emerged as a medical miracle to attain hypog
Externí odkaz:
https://doaj.org/article/f987d924f3f24e58a87a52c072e8185e
Autor:
Michael Nooromid, Edmund B. Chen, Liqun Xiong, Katherine Shapiro, Qun Jiang, Falen Demsas, Maeve Eskandari, Medha Priyadarshini, Eugene B. Chang, Brian T. Layden, Karen J. Ho
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 13 (2020)
Background Arterial restenosis after vascular surgery is a common cause of midterm restenosis and treatment failure. Herein, we aim to investigate the role of microbe‐derived butyrate, FFAR2 (free fatty acid receptor 2), and FFAR3 (free fatty acid
Externí odkaz:
https://doaj.org/article/f13162973c26435e93b3e269b3ea5655
Autor:
Soh Yamamoto, Kenta Kuramoto, Nan Wang, Xiaolei Situ, Medha Priyadarshini, Weiran Zhang, Jose Cordoba-Chacon, Brian T. Layden, Congcong He
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3286-3299 (2018)
Summary: Autophagy, a stress-induced lysosomal degradative pathway, has been assumed to exert similar metabolic effects in different organs. Here, we establish a model where autophagy plays different roles in insulin-producing β cells versus insulin
Externí odkaz:
https://doaj.org/article/880c3bdc483c4ec48558da95ea856b24
Autor:
Medha Priyadarshini, Kristen Lednovich, Kai Xu, Sophie Gough, Barton Wicksteed, Brian T. Layden
Publikováno v:
Metabolites, Vol 11, Iss 5, p 302 (2021)
The gut microbiome has emerged as a novel determinant of type 1 diabetes (T1D), but the underlying mechanisms are unknown. In this context, major gut microbial metabolites, short-chain fatty acids (SCFAs), are considered to be an important link betwe
Externí odkaz:
https://doaj.org/article/da67a29d55e843fca0a28b4a5d4a5983
Autor:
Elena Barengolts, Arfana Akbar, Brian T. Layden, Yuval Eisenberg, Medha Priyadarshini, Jeffrey A. Borgia, Cristina L. Fhied, Michael Salim, Lara R. Dugas
Publikováno v:
Biomedicines, Vol 8, Iss 11, p 520 (2020)
This study explored adipocytokine associations with acute and chronic hyperglycemia in African-American men (AAM). Fourteen adipocytokines were measured from men with normal glucose tolerance (NGT) or type 2 diabetes (T2D, drug-naïve MF(−) or usin
Externí odkaz:
https://doaj.org/article/9e07e689f9fe498b8d475bea0805654e
Autor:
Elena Barengolts, Stefan J. Green, George E. Chlipala, Brian T. Layden, Yuval Eisenberg, Medha Priyadarshini, Lara R. Dugas
Publikováno v:
Microorganisms, Vol 7, Iss 9, p 320 (2019)
Gut microbiota and their biomarkers may be associated with obesity. This study evaluated associations of body mass index (BMI) with circulating microbiota biomarkers in African American men (AAM) (n = 75). The main outcomes included fecal microbial c
Externí odkaz:
https://doaj.org/article/d45c741ee63b42879fb751ec675a09ce
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:678-687
Hexokinase domain containing 1, a recently discovered putative fifth hexokinase, is hypothesized to play key roles in glucose metabolism. Specifically, during pregnancy in a recent genome wide association study (GWAS), a strong correlation between HK
Publikováno v:
Trends in Endocrinology & Metabolism. 27:653-664
Nutrient sensing receptors are key metabolic mediators of responses to dietary and endogenously derived nutrients. These receptors are largely G-protein coupled receptors (GPCRs) and many are gaining significant interest as drug targets with a potent