Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Hui K. Gan"'
Autor:
Nalin H. Maniya, Sonu Kumar, Jeffrey L. Franklin, James N. Higginbotham, Andrew M. Scott, Hui K. Gan, Robert J. Coffey, Satyajyoti Senapati, Hsueh-Chia Chang
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract We present a quantitative sandwich immunoassay for CD63 Extracellular Vesicles (EVs) and a constituent surface cargo, EGFR and its activity state, that provides a sensitive, selective, fluorophore-free and rapid alternative to current EV-bas
Externí odkaz:
https://doaj.org/article/73f922b965a546b2a477dcf2d44e21d8
Autor:
Georgia K. B. Halkett, Lauren J. Breen, Melissa Berg, Rebecca Sampson, Hao-Wen Sim, Hui K. Gan, Benjamin Y. Kong, Anna K. Nowak, Bryan W. Day, Rosemary Harrup, Melissa James, Frank Saran, Brett Mcfarlane, Chris Tse, Eng-Siew Koh
Publikováno v:
Current Oncology, Vol 29, Iss 12, Pp 9928-9955 (2022)
The aim of this project was to determine research priorities, barriers, and enablers for adult primary brain tumour research in Australia and New Zealand. Consumers, health professionals, and researchers were invited to participate in a two-phase mod
Externí odkaz:
https://doaj.org/article/6cd87a96459d43ed8dda66d8c3a38599
Autor:
Lucy Gately, Katharine Drummond, Mark Rosenthal, Rosemary Harrup, Anthony Dowling, Andrew Gogos, Zarnie Lwin, Ian Collins, David Campbell, Elizabeth Ahern, Claire Phillips, Hui K. Gan, Iwan Bennett, Oliver M. Sieber, Peter Gibbs
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background Real-world data (RWD) is increasingly being embraced as an invaluable source of information to address clinical and policy-relevant questions that are unlikely to ever be answered by clinical trials. However, the largely unrealise
Externí odkaz:
https://doaj.org/article/dde2958b8619435fbac30562014e21eb
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 3, Iss 2, Pp 252-277 (2022)
The recent approvals for antibody-drug conjugates (ADCs) in multiple malignancies in recent years have fuelled the ongoing development of this class of drugs. These novel agents combine the benefits of high specific targeting of oncogenic cell surfac
Externí odkaz:
https://doaj.org/article/3d8ef975652545ae9c093e8ae0cb2d09
Publikováno v:
Cancers, Vol 14, Iss 6, p 1454 (2022)
Radioimmunoconjugates consist of a monoclonal antibody (mAb) linked to a radionuclide. Radioimmunoconjugates as theranostics tools have been in development with success, particularly in hematological malignancies, leading to approval by the US Food a
Externí odkaz:
https://doaj.org/article/e678ac54095140e799c2f15f0a073adf
Autor:
Juliana Gomez, Zammam Areeb, Sarah F. Stuart, Hong P. T. Nguyen, Lucia Paradiso, Ahmad Zulkifli, Sonakshi Madan, Vijay Rajagopal, Magdalene K. Montgomery, Hui K. Gan, Andrew M. Scott, Jordan Jones, Andrew H. Kaye, Andrew P. Morokoff, Rodney B. Luwor
Publikováno v:
Cancers, Vol 13, Iss 6, p 1198 (2021)
Reticulocalbin 1 (RCN1) is an endoplasmic reticulum (ER)-residing protein, involved in promoting cell survival during pathophysiological conditions that lead to ER stress. However, the key upstream receptor tyrosine kinase that regulates RCN1 express
Externí odkaz:
https://doaj.org/article/4e7ab66647e94fccb77f168917810ebd
Publikováno v:
Molecules, Vol 25, Iss 20, p 4764 (2020)
Antibody–drug conjugates (ADCs) are novel drugs that exploit the specificity of a monoclonal antibody (mAb) to reach target antigens expressed on cancer cells for the delivery of a potent cytotoxic payload. ADCs provide a unique opportunity to deli
Externí odkaz:
https://doaj.org/article/fd2c927ee8a84b3fa0e7808f9755a84a
Autor:
Puey-Ling Chia, Sagun Parakh, Ming-Sound Tsao, Nhu-An Pham, Hui K. Gan, Diana Cao, Ingrid J. G. Burvenich, Angela Rigopoulos, Edward B. Reilly, Thomas John, Andrew M. Scott
Publikováno v:
Pharmaceuticals, Vol 13, Iss 10, p 289 (2020)
Epidermal growth factor receptor (EGFR) is highly overexpressed in malignant mesothelioma (MM). MAb806 is a novel anti-EGFR antibody that selectively targets a tumor-selective epitope. MAb806-derived antibody drug conjugates (ADCs), ABT-414, ABBV-221
Externí odkaz:
https://doaj.org/article/fe2d9f07976d49e8880342331b1b8d0a
Publikováno v:
Pharmaceuticals, Vol 13, Iss 5, p 88 (2020)
The Eph subfamily of receptor tyrosine kinases mediate cell-cell communication controlling cell and tissue patterning during development. While generally less active in adult tissues, they often re-emerge in cancers, particularly on undifferentiated
Externí odkaz:
https://doaj.org/article/09149a8f336840329bd807b6ed6cd181
Autor:
Fook T. Lee PhD, Ingrid J. G. Burvenich PhD, Nancy Guo MBBS, MSc, Pece Kocovski BSc (Honors), Henri Tochon-Danguy PhD, Uwe Ackermann PhD, Graeme J. O’Keefe PhD, Sylvia Gong PhD, Angela Rigopoulos BSc, MSc, Zhanqi Liu MBBS, PhD, Hui K. Gan MBBS, FRACP, PhD, Andrew M. Scott MBBS, FRACP, MD
Publikováno v:
Molecular Imaging, Vol 15 (2016)
Purpose: The aims of the study were to develop and evaluate a novel residualizing peptide for labeling internalizing antibodies with 124 I to support clinical development using immuno-positron emission tomography (PET). Methods: The anti-epidermal gr
Externí odkaz:
https://doaj.org/article/ec906d2158ff44d483cd65511d1e09d3