Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Huck-Hui Ng"'
Publikováno v:
Cell Regeneration, Vol 10, Iss 1, Pp 1-19 (2021)
Abstract Building human organs in a dish has been a long term goal of researchers in pursue of physiologically relevant models of human disease and for replacement of worn out and diseased organs. The liver has been an organ of interest for its centr
Externí odkaz:
https://doaj.org/article/38b5740317334f88a7d1f00ac83a8c60
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8155 (2009)
BACKGROUND:How transcription factors (TFs) interact with cis-regulatory sequences and interact with each other is a fundamental, but not well understood, aspect of gene regulation. METHODOLOGY/PRINCIPAL FINDINGS:We present a computational method to a
Externí odkaz:
https://doaj.org/article/7c334ce1c8334d6d851848b77af6dce2
Autor:
Zhengyi Li, Haiyan Xu, Jiaqun Li, Xiao Xu, Junjiao Wang, Danya Wu, Jiateng Zhang, Juan Liu, Ziwei Xue, Guankai Zhan, Bobby Cheng Peow Tan, Di Chen, Yun-Shen Chan, Huck Hui Ng, Wanlu Liu, Chih-Hung Hsu, Dan Zhang, Yang Shen, Hongqing Liang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Acquisition of new stem cell fates relies on the dissolution of the prior regulatory network sustaining the existing cell fates. Currently, extensive insights have been revealed for the totipotency regulatory network around the zygotic genom
Externí odkaz:
https://doaj.org/article/35b1d34d886b45658cb76ff50e98280b
Autor:
Mui Hoon Nai, Hoang-Dai Tran, Huck-Hui Ng, Chwee Teck Lim, Kah-Leong Lim, Haidun Yan, Koji Itahana, Menglan Zhang, Stephanie Wai Lin Lim, Qiang Yuan, Yoko Itahana, Giuseppe D'Agostino, Yong-hui Jiang, Alfred Xuyang Sun, Eng-King Tan, Danlei Wang, Hidayat Lokman, Owen J. L. Rackham, Weonjin Yu, Stuart A. Cook, Grace Lim, Ya Yin Chang, Masahiro Fukuda, Hyunsoo Shawn Je, Jiong Tang
Publikováno v:
Science. 366:1486-1492
Hyperexcitable neurons in brain organoids Individuals with Angelman syndrome experience intellectual disability and seizures throughout their lives. In this condition, ubiquitin-mediated degradation of a key potassium channel is disrupted, allowing f
Autor:
Yong-An Lee, Chee Chong Lek, Amanpreet Kaur, Rong Gao, Agnes Bee Leng Ong, Yee Siang Lim, Shirleen Soh, Winston Chan, Yock Young Dan, Huck Hui Ng, Torsten Wuestefeld
Publikováno v:
Journal of Hepatology. 77:S694
Autor:
Lin Yang, Huck-Hui Ng
Publikováno v:
Science. 373:282-283
Ovarian somatic cells are derived in vitro from pluripotent embryonic stem cells
Publikováno v:
Annals of Clinical and Translational Neurology
The recent technology of 3D cultures of cellular aggregates derived from human stem cells have led to the emergence of tissue‐like structures of various organs including the brain. Brain organoids bear molecular and structural resemblance with deve
Autor:
Huck-Hui Ng, M. Azim Surani
Publikováno v:
Nature Cell Biology. 13:490-496
Pluripotency and self-renewal are the hallmarks of embryonic stem cells. This state is maintained by a network of transcription factors and is influenced by specific signalling pathways. Current evidence indicates that multiple pluripotent states can
Autor:
LeeAnn Ramsay, Xinyi Lu, Pierre-Étienne Jacques, Friedrich Sachs, Guillaume Bourque, Jonathan Göke, Huck-Hui Ng
Publikováno v:
Nature Structural & Molecular Biology. 21:423-425
Human endogenous retrovirus subfamily H (HERVH) is a class of transposable elements expressed preferentially in human embryonic stem cells (hESCs). Here, we report that the long terminal repeats of HERVH function as enhancers and that HERVH is a nucl
Autor:
Yun-Shen Chan, Galih Kunarso, Huck-Hui Ng, Justin Jeyakani, Catalina Hwang, Na-Yu Chia, Xinyi Lu, Guillaume Bourque
Publikováno v:
Nature Genetics. 42:631-634
Detection of new genomic control elements is critical in understanding transcriptional regulatory networks in their entirety. We studied the genome-wide binding locations of three key regulatory proteins (POU5F1, also known as OCT4; NANOG; and CTCF)