Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Hannu Koistinen"'
Autor:
Hannu Koistinen, Sonja Boyd, Johanna Arola, Kalle Jokelainen, Riitta Koistinen, Anna Lempiäinen, Kristina Hotakainen, Ulf-Håkan Stenman, Martti Färkkilä
Publikováno v:
Livers, Vol 1, Iss 4, Pp 322-329 (2021)
Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease, which is associated with an increased risk of cholangiocarcinoma (CCA). Novel markers, to complement or replace CA19-9, are urgently needed for the screening of PSC-associated bi
Externí odkaz:
https://doaj.org/article/758fa20208f5431494eca0a410f85e4d
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13545 (2021)
In this focused review, we address the role of the kallikrein-related peptidase 3 (KLK3), also known as prostate-specific antigen (PSA), in the regulation of angiogenesis. Early studies suggest that KLK3 is able to inhibit angiogenic processes, which
Externí odkaz:
https://doaj.org/article/1225a6d9951d493ba8b5ff42af22476a
Autor:
Maria H. Jäntti, Virpi Talman, Kati Räsänen, Ilari Tarvainen, Hannu Koistinen, Raimo K. Tuominen
Publikováno v:
FEBS Open Bio, Vol 8, Iss 5, Pp 817-828 (2018)
Prostate cancer is one of the most common cancers in men. Although it has a relatively high 5‐year survival rate, development of resistance to standard androgen‐deprivation therapy is a significant clinical problem. Therefore, novel therapeutic s
Externí odkaz:
https://doaj.org/article/04c1350fde84491bb7286f40dc0a2c00
Autor:
Kati Räsänen, Kien X. Dang, Harri Mustonen, Tho H. Ho, Susanna Lintula, Hannu Koistinen, Ulf‐Håkan Stenman, Caj Haglund, Jakob Stenman
Publikováno v:
Molecular Oncology, Vol 12, Iss 2, Pp 224-238 (2018)
The mitogen‐activated protein kinase (MAPK) pathway plays a central role in colorectal cancers (CRC). In particular, BRAF V600E‐mutant tumors, which represent around 10% of CRCs, are refractory to current therapies. Overexpression and secretion o
Externí odkaz:
https://doaj.org/article/86377942144a4085994002376e60316c
Autor:
Michelle De bruyn, Hannah Ceuleers, Nikita Hanning, Maya Berg, Joris G. De Man, Paco Hulpiau, Cedric Hermans, Ulf-Håkan Stenman, Hannu Koistinen, Anne-Marie Lambeir, Benedicte Y. De Winter, Ingrid De Meester
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10711 (2021)
The protease activity in inflammatory bowel disease (IBD) and irritable bowel syndrome has been studied extensively using synthetic fluorogenic substrates targeting specific sets of proteases. We explored activities in colonic tissue from a 2,4,6-tri
Externí odkaz:
https://doaj.org/article/70a1460f3b9e4ab2ae8de5869eec14f7
Autor:
Sawan Kumar Jha, Khushbu Rauniyar, Ewa Chronowska, Kenny Mattonet, Eunice Wairimu Maina, Hannu Koistinen, Ulf-Håkan Stenman, Kari Alitalo, Michael Jeltsch
Publikováno v:
eLife, Vol 8 (2019)
Vascular endothelial growth factor-C (VEGF-C) acts primarily on endothelial cells, but also on non-vascular targets, for example in the CNS and immune system. Here we describe a novel, unique VEGF-C form in the human reproductive system produced via
Externí odkaz:
https://doaj.org/article/e097b88514914dc3a4bc098e00f63dc8
Autor:
Johanna M Mattsson, Suvi Ravela, Can Hekim, Magnus Jonsson, Johan Malm, Ale Närvänen, Ulf-Håkan Stenman, Hannu Koistinen
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107819 (2014)
Prostate-specific antigen (PSA or kallikrein-related peptidase-3, KLK3) exerts chymotrypsin-like proteolytic activity. The main biological function of PSA is the liquefaction of the clot formed after ejaculation by cleavage of semenogelins I and II i
Externí odkaz:
https://doaj.org/article/1f1c120f20594723b2832bec8b0fcda8
Autor:
Hannu Koistinen, Riitta Koistinen, Kristina Hotakainen, Anna Lempiäinen, Kalle Jokelainen, Martti Färkkilä, Ulf-Håkan Stenman
Publikováno v:
Analytical Biochemistry. 648:114681
Trypsin has been identified as a pancreatic protease comprising three isoenzymes, trypsin-1,-2, and-3. However, the gene for trypsinogen-3, PRSS3, also gives rise to additional variants, trypsinogen-4A and B, which differ from trypsinogen-3 only with
Autor:
Ulf-Håkan Stenman, Johanna Wennervirta, Anne Vakkuri, Anna Lempiäinen, Hannu Koistinen, Kristina Hotakainen, Juhani A Stewart, Riitta Koistinen, Ulla-Stina Salminen
Publikováno v:
Scandinavian journal of clinical and laboratory investigation. 80(8)
The concentrations of several diagnostic markers have been found to increase dramatically in critically ill patients with a severe disturbance of normal physiological homeostasis, without indication of the diseases they are normally associated with.
Autor:
Ulf-Håkan Stenman, Ilpo Huhtaniemi, Mirhan Kapidzic, Yaqi Zhao, Nicholas Larocque, Hannu Koistinen, Lei V. Zhan, Jennifer J. Adibi
Publikováno v:
Environmental Health Perspectives
Environmental health perspectives, vol 125, iss 10
Environmental health perspectives, vol 125, iss 10
Background: Observational studies have reported associations between maternal phthalate levels and adverse outcomes at birth and in the health of the child. Effects on placental function have been suggested as a biologic basis for these findings. Obj