Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Guangxun Meng"'
Autor:
Danfeng Dong, Yuzhang Du, Xuefeng Fei, Hao Yang, Xiaofang Li, Xiaobao Yang, Junrui Ma, Shu Huang, Zhihui Ma, Juanjuan Zheng, David W. Chan, Liyun Shi, Yunqi Li, Aaron T. Irving, Xiangliang Yuan, Xiangfan Liu, Peihua Ni, Yiqun Hu, Guangxun Meng, Yibing Peng, Anthony Sadler, Dakang Xu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Inflammasome activity is important for the immune response and is instrumental in numerous clinical conditions. Here we identify a mechanism that modulates the central Caspase-1 and NLR (Nod-like receptor) adaptor protein ASC (apoptosis-asso
Externí odkaz:
https://doaj.org/article/7f19608cb89141d283f2dcd9b36f3fb4
Autor:
Xin Yang, Zhiyi Wang, Junling Niu, Rui Zhai, Xinhe Xue, Guojun Wu, Yuanyuan Fang, Guangxun Meng, Huijuan Yuan, Liping Zhao, Chenhong Zhang
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-20 (2023)
Abstract Background Dysbiotic gut microbiome, genetically predisposed or chemically disrupted, has been linked with insulin-dependent diabetes (IDD) including autoimmune type 1 diabetes (T1D) in both humans and animal models. However, specific IDD-in
Externí odkaz:
https://doaj.org/article/0ffca464297e4d4793ddaefd32d05767
Autor:
Shi Yu, Xu Zheng, Yanqiu Zhou, Yuhui Gao, Bingjie Zhou, Yapei Zhao, Tingting Li, Yunyi Li, Jiabin Mou, Xiaoxian Cui, Yuying Yang, Dianfan Li, Min Chen, Dimitri Lavillette, Guangxun Meng
Publikováno v:
PLoS Pathogens, Vol 19, Iss 11, p e1011789 (2023)
The COVID pandemic fueled by emerging SARS-CoV-2 new variants of concern remains a major global health concern, and the constantly emerging mutations present challenges to current therapeutics. The spike glycoprotein is not only essential for the ini
Externí odkaz:
https://doaj.org/article/95a69b5254724c368e17456771ac2be0
Autor:
Junling Niu, Mengmeng Cui, Xin Yang, Juan Li, Yuhui Yao, Qiuhong Guo, Ailing Lu, Xiaopeng Qi, Dongming Zhou, Chenhong Zhang, Liping Zhao, Guangxun Meng
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
The NLRP3 inflammasome plays a pivotal role in clearing viral respiratory infection, but the molecular mechanism is not fully known. Here authors show that acetate, produced by gut bacteria, may enhance NLRP3-mediated type I interferon production fol
Externí odkaz:
https://doaj.org/article/aadf1ef849a44449b71611edcfea5787
Autor:
Wenbo Zhang, Zhe Cai, Dandan Liang, Jiaochan Han, Ping Wu, Jiayi Shan, Guangxun Meng, Huasong Zeng
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10619 (2023)
Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in children. The heterogeneity of the disease can be investigated via single-cell RNA sequencing (scRNA-seq) for its gap in the literature. Firstly, five types of immune
Externí odkaz:
https://doaj.org/article/60e6c638f98a4f6e85faab0f8627f400
Autor:
Junling Niu, Guangxun Meng
Publikováno v:
Viruses, Vol 15, Iss 6, p 1339 (2023)
Pathogenic viral infection represents a major challenge to human health. Due to the vast mucosal surface of respiratory tract exposed to the environment, host defense against influenza viruses has perpetually been a considerable challenge. Inflammaso
Externí odkaz:
https://doaj.org/article/0829b5365fab48da9e325ad721eae360
Autor:
Liming Mao, Atika Dhar, Guangxun Meng, Ivan Fuss, Kim Montgomery-Recht, Zhiqiong Yang, Qiuyun Xu, Atsushi Kitani, Warren Strober
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The studies described here provide an analysis of the pathogenesis of Blau syndrome and thereby the function of NOD2 as seen through the lens of its dysfunction resulting from Blau-associated NOD2 mutations in its nucleotide-binding domain (NBD). As
Externí odkaz:
https://doaj.org/article/5b47c420c24a4ec0821c1dbd820857bd
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/c76e7f14d71d45cc97440ac0f086bdbc
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
ObjectiveTo explore the role of the Nlrp3 inflammasome activation in the development of hemolytic uremic syndrome (HUS) induced by Stx2 and evaluate the efficacy of small molecule Nlrp3 inhibitors in preventing the HUS.MethodsPeritoneal macrophages (
Externí odkaz:
https://doaj.org/article/e17ef13d9c7146bf8739b82f6807aac3
Autor:
Liqiong Song, Xianping Li, Yuchun Xiao, Yuanming Huang, Yongqiang Jiang, Guangxun Meng, Zhihong Ren
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Objective: The aim of this study was to investigate the molecular mechanism of inflammasome activation in response to Streptococcus suis serotype 2 (SS2) infection and its contribution to the development of streptococcal toxic shock-like syndrome (ST
Externí odkaz:
https://doaj.org/article/e152c66e743e489b912d10192d81a3a5