Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Denise D. Belsham"'
Autor:
Wenyuan He, Denise D. Belsham
Publikováno v:
Biomedicines, Vol 12, Iss 4, p 857 (2024)
Cellular microRNAs (miRNAs) can be selectively secreted or retained, adding another layer to their critical role in regulating human health and disease. To date, select RNA-binding proteins (RBPs) have been proposed to be a mechanism underlying miRNA
Externí odkaz:
https://doaj.org/article/061c2784deb84467b8c20f844ecb3a89
Publikováno v:
Genes, Vol 15, Iss 4, p 397 (2024)
Diets high in saturated fatty acids are associated with obesity and infertility. Palmitate, the most prevalent circulating saturated fatty acid, is sensed by hypothalamic neurons, contributing to homeostatic dysregulation. Notably, palmitate elevates
Externí odkaz:
https://doaj.org/article/6cde1f7faffa4c0e85f748e62abc06f2
Publikováno v:
Genes, Vol 14, Iss 9, p 1773 (2023)
The hypothalamus is a vital regulator of energy homeostasis. Orexigenic neuropeptide Y (NPY) neurons within the hypothalamus can stimulate feeding and suppress energy expenditure, and dysregulation of these neurons may contribute to obesity. We previ
Externí odkaz:
https://doaj.org/article/7be3e40697214597be8b55392be2b04a
Autor:
David W. Hogg, Claudio C. Casatti, Denise D. Belsham, Dalia Baršytė-Lovejoy, David A. Lovejoy
Publikováno v:
Biochemistry and Biophysics Reports, Vol 32, Iss , Pp 101397- (2022)
Teneurin C-terminal associated peptides (TCAP) are natural bioactive peptides that possess anxiety-reducing roles in animals, in vivo, and increase cell viability, in vitro. Although these peptides have some primary structural similarity to corticotr
Externí odkaz:
https://doaj.org/article/a2a2aeb512304f12b9f8a33c4654ea9b
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Obesity is a prominent metabolic disease that predisposes individuals to multiple comorbidities, including type 2 diabetes mellitus, cardiovascular diseases, and cancer. Elevated circulating levels of fatty acids contribute to the development of obes
Externí odkaz:
https://doaj.org/article/c11fe0311ec341a2972d8772672cfeee
Publikováno v:
Cells, Vol 10, Iss 11, p 3120 (2021)
The hypothalamus maintains whole-body homeostasis by integrating information from circulating hormones, nutrients and signaling molecules. Distinct neuronal subpopulations that express and secrete unique neuropeptides execute the individual functions
Externí odkaz:
https://doaj.org/article/8b318e48496a4c43b8fda1c57a3de04a
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Phoenixin (PNX) is a newly identified reproductive peptide required for the estrous cycle. It is most highly expressed in the hypothalamus, where it is a positive regulator of gonadotropin-releasing hormone (GnRH) and kisspeptin. However, it is unkno
Externí odkaz:
https://doaj.org/article/fda353ea5952444ea574f6bfb74ddc6f
Publikováno v:
Biochemical and Biophysical Research Communications. 658:18-26
Autor:
Emma K. McIlwraith, Denise D. Belsham
Publikováno v:
Brain Research. 1810:148367
Autor:
Wenyuan He, Andy Tran, Chuck T. Chen, Neruja Loganathan, Richard P. Bazinet, Denise D. Belsham
Publikováno v:
Molecular and cellular endocrinology. 557
Accumulation of excess lipids in non-adipose tissues, such as the hypothalamus, is termed lipotoxicity and causative of free fatty acid-mediated pathology in metabolic disease. This study aimed to elucidate the molecular mechanisms behind oleate (OA)