Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christoph W. Grathwol"'
Autor:
Lu Sun, Matthias Apweiler, Claus Normann, Christoph W. Grathwol, Thomas Hurrle, Simone Gräßle, Nicole Jung, Stefan Bräse, Bernd L. Fiebich
Publikováno v:
Pharmaceuticals, Vol 17, Iss 6, p 674 (2024)
Chronic inflammation is driven by proinflammatory cytokines such as interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α), and chemokines, such as c-c motif chemokine ligand 2 (CCL2), CCL3, C-X-C motif chemokine ligand 2 (CXCL2), and CXCL10. Inflam
Externí odkaz:
https://doaj.org/article/5dec51038a2b4687ba75c872588109e1
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 75, Iss 12, Pp 1828-1832 (2019)
The title compound, C14H10N2O, crystallizes in the monoclinic space group P21/c with four molecules in the unit cell. All 17 non-H atoms of one molecule lie essentially in one plane. In the unit cell, two pairs of molecules are exactly coplanar, whil
Externí odkaz:
https://doaj.org/article/c83755248654483ab39379a6a2163400
Autor:
Christoph W. Grathwol, Nathalie Wössner, Sören Swyter, Adam C. Smith, Enrico Tapavicza, Robert K. Hofstetter, Anja Bodtke, Manfred Jung, Andreas Link
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2170-2183 (2019)
The use of light as an external trigger to change ligand shape and as a result its bioactivity, allows the probing of pharmacologically relevant systems with spatiotemporal resolution. A hetero-stilbene lead resulting from the screening of a compound
Externí odkaz:
https://doaj.org/article/041a892fdab9473da4a1b78601dea26f
Autor:
Steven Behnisch-Cornwell, Christoph W. Grathwol, Lukas Schulig, Anika Voigt, Daniel Baecker, Andreas Link, Patrick J. Bednarski
Publikováno v:
Cancers, Vol 14, Iss 1, p 187 (2021)
Inhibiting the activity of histone deacetylase (HDAC) is an ongoing strategy in anticancer therapy. However, to our knowledge, the relationships between the expression of HDAC proteins and the antitumor drug sensitivity of cancer cells have not been
Externí odkaz:
https://doaj.org/article/506bd154408245ab8984631358d1c9e3
Autor:
Sascha Grobe, Thomas Bayer, Emil Hamnevik, Sven Koban, Uwe T. Bornscheuer, Shuke Wu, Beatrice Großjohann, Christoph W. Grathwol, Christoffel P. S. Badenhorst, Andreas Link, Henrike Brundiek
Publikováno v:
Angewandte Chemie (International Ed. in English)
We engineered the cytochrome P450 monooxygenase CYP107D1 (OleP) from Streptomyces antibioticus for the stereo‐ and regioselective 7β‐hydroxylation of lithocholic acid (LCA) to yield ursodeoxycholic acid (UDCA). OleP was previously shown to hydro
Autor:
Christoffel P. S. Badenhorst, Uwe T. Bornscheuer, Shuke Wu, Beatrice Großjohann, Sven Koban, Thomas Bayer, Henrike Brundiek, Christoph W. Grathwol, Sascha Grobe, Emil Hamnevik, Andreas Link
Publikováno v:
Angewandte Chemie. 133:764-768
Autor:
Christoph W. Grathwol, Klaus Weisz, Yoanes Maria Vianney, Andreas Link, Qingyun Tang, Ioannis V. Pavlidis, Uwe T. Bornscheuer
Publikováno v:
ChemCatChem. 12:3721-3727
Methylation of free hydroxyl groups is an important modification for flavonoids. It not only greatly increases absorption and oral bioavailability of flavonoids, but also brings new biological activities. Flavonoid methylation is usually achieved by
Autor:
Christian Bock, Andreas Link, Robert K. Hofstetter, Werner Siegmund, Felix Potlitz, Abdrrahman Shemsu Surur, Georg M. Fassauer, Tobias Oergel, Christoph W. Grathwol, Mahmoud Hasan, Steven Behnisch
Publikováno v:
Journal of Chromatography A. 1603:338-347
Supercritical fluid chromatography (SFC) holds the potential to become an orthogonal method to HPLC/UHPLC in xenobiotic metabolism studies, due to its outstanding capacity to simultaneously separate highly similar (as HPLC) and physicochemically diff
Autor:
Qingyun Tang, Christoph W. Grathwol, Shuke Wu, Christoffel P. S. Badenhorst, Andreas Link, Aşkın S. Aslan-Üzel, Ioannis V. Pavlidis, Uwe T. Bornscheuer
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie (International Ed. in English)
Angewandte Chemie (International Ed. in English)
Biocatalytic alkylations are important reactions to obtain chemo‐, regio‐ and stereoselectively alkylated compounds. This can be achieved using S‐adenosyl‐l‐methionine (SAM)‐dependent methyltransferases and SAM analogs. It was recently sh
Autor:
Lukas Schulig, Andreas Link, Nathalie Wössner, Steven Behnisch‐Cornwell, Christoph W. Grathwol, Manfred Jung, Oliver Einsle, Lin Zhang
Publikováno v:
Chemmedchem
Because isoenzymes of the experimentally and therapeutically extremely relevant sirtuin family show high similarity, addressing the unique selectivity pocket of sirtuin 2 is a promising strategy towards selective inhibitors. An unrelated approach tow