Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Charles S. Carter"'
Autor:
Aarthi Shenoy, Richard W. Childs, Susan F. Leitman, Elizabeth J. Read, Aldemar Montero, Katayoun Rezvani, Charles S. Carter, Stephan Mielke, Bipin N. Savani, A. John Barrett
Publikováno v:
Biology of Blood and Marrow Transplantation. 12:1318-1325
One hundred thirty-eight patients with hematologic malignancies received myeloablative T cell-depleted peripheral blood stem cell transplant (PBSCT) from an HLA-identical sibling donor. The T cell dose was adjusted to 0.2-1 x 10(5) CD3(+) cells/kg. T
Autor:
Charles S. Carter, Hua Zhang, Margaret V. Brown, Brenna J. Hill, Daniel C. Douek, Thomas A. Fleisher, Lauren M. Long, Jay A. Berzofsky, Martin Guimond, Donna Bernstein, Elizabeth J. Read, Kevin S. Chua, Veena Kapoor, Crystal L. Mackall, Lee J. Helman
Publikováno v:
Nature Medicine. 11:1238-1243
CD4(+)CD25(+) regulatory T (T(reg)) cells have a crucial role in maintaining immune tolerance. Mice and humans born lacking T(reg) cells develop severe autoimmune disease, and depletion of T(reg) cells in lymphopenic mice induces autoimmunity. Interl
Autor:
Susan F. Leitman, Elizabeth J. Read, Claude Kasten-Sportes, Steven Z. Pavletic, Kathleen Castro, Michael Krumlauf, Donna Marchigiani, Juan Gea-Banacloche, Seth M. Steinberg, Nancy M. Hardy, Ronald E. Gress, Frances T. Hakim, Charles S. Carter, Michael R. Bishop, Daniel H. Fowler, Robert M. Dean
Publikováno v:
British Journal of Haematology. 126:837-843
SummaryMixed chimaerism and graft rejection are higher after reduced-intensityallogeneic stem cell transplantation (RIST) with T-cell depleted (TCD)allografts. As host immune status before RIST affects engraftment, wehypothesized that targeted deplet
Autor:
F. Stock, M. McGann, Charles S. Carter, Patrick R. Murray, J.W. Atkins, Elizabeth J. Read, Hanh Khuu
Publikováno v:
Cytotherapy. 6:183-195
Background Although widely used, commercially available automated culture methods are not US Food and Drug Administration-approved for sterility testing of cell-therapy products. For cell-therapy products regulated under Section 351 of the Public Hea
Autor:
Yu Ying Yau, Richard W. Childs, Robert Wesley, Elizabeth J. Read, Susan F. Leitman, Charles D. Bolan, Charles S. Carter, A. John Barrett
Publikováno v:
British Journal of Haematology. 120:801-807
Summary. We report cell kinetics, yields and donation experiences of 20 demographically matched allogeneic peripheral blood stem cell (PBSC) donors who were prospectively assigned to undergo either a single 25 l or two consecutive daily 15 l (15 l ×
Autor:
Theresa J. Goletz, Charles S. Carter, Crystal L. Mackall, E.C.C. Wong, Kenneth Hines, V.E. Maher, Elizabeth J. Read, William Kopp, Janet Lee, Jay A. Berzofsky
Publikováno v:
Cytotherapy. 3:19-29
Background There is growing interest in the use of dendritic cells (DCs) for treatment of malignancy and infectious disease. Our goal was to develop a clinicalscale method to prepare autologous DCs for cancer clinical trials. Methods PBMC were collec
Autor:
Nancy F. Hensel, Dimitrios Mavroudis, Martha Kirby, Elaine M. Sloand, Richard W. Childs, Anastasios Raptis, Elizabeth J. Read, John Barrett, Charles S. Carter, Frits van Rhee, Vaishali Agarwala, Emmanuel Clave, Faye Vigue, Y. Z. Jiang
Publikováno v:
British Journal of Haematology. 105:1014-1024
To investigate mechanisms of stem cell graft rejection we studied the allo-stimulatory potential of G-CSF mobilized peripheral blood progenitor cells (PBPC). CD34+ cells were purified (> 95%) in a two-step procedure using immunoaffinity columns for C
Autor:
Michelle Plante, Sheila Phang, Austin John Barrett, Cynthia E. Dunbar, Anastasios Raptis, Dimitrios Mavroudis, Charles S. Carter, Jeffrey J. Molldrem, Elizabeth J. Read
Publikováno v:
Bone Marrow Transplantation. 21:431-440
To increase the stem cell content of T cell-depleted bone marrow transplants (BMT), we treated 12 patients with hematological malignancies with BMT from HLA-identical sibling donors given G-CSF 10 microg/kg/day for 5 days before marrow harvest. After
Publikováno v:
Transfusion. 46(12)
BACKGROUND: Automated blood culture systems are not FDA-approved for sterility testing of human cells, tissues, or cellular- or tissue-based products. It was previously demonstrated that BacT/ALERT (bioMerieux) and Bactec (Becton Dickinson) were supe
Publikováno v:
Transfusion. 46(9)
BACKGROUND: Fluorinated ethylene-propylene (FEP) bags have been used instead of polystyrene (PS) flasks for ex vivo clinical-scale production of human dendritic cells (DCs) to facilitate closed-system recovery of these highly adherent cells. To asses