Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Chan-I Chung"'
Autor:
Wen-Hao Guo, Xiaoli Qi, Xin Yu, Yang Liu, Chan-I Chung, Fang Bai, Xingcheng Lin, Dong Lu, Lingfei Wang, Jianwei Chen, Lynn Hsiao Su, Krystle J. Nomie, Feng Li, Meng C. Wang, Xiaokun Shu, José N. Onuchic, Jennifer A. Woyach, Michael L. Wang, Jin Wang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
PROTACs have emerged as promising therapeutic agents but their cellular uptake is often inefficient. Here, the authors show that reversible covalent warhead chemistry improves PROTAC intracellular accumulation and target engagement, and develop a dua
Externí odkaz:
https://doaj.org/article/4979b2c9fe654e15a019e2b5da2998c8
Autor:
Junjiao Yang, Yinghong Xiao, Peter V. Lidsky, Chien-Ting Wu, Luke R. Bonser, Shiming Peng, Miguel A. Garcia-Knight, Michel Tassetto, Chan-I Chung, Xiaoquan Li, Tsuguhisa Nakayama, Ivan T. Lee, Jayakar V. Nayak, Khadija Ghias, Kirsten L. Hargett, Brian K. Shoichet, David J. Erle, Peter K. Jackson, Raul Andino, Xiaokun Shu
Publikováno v:
Nat Microbiol
Nature microbiology, vol 8, iss 1
Nature microbiology, vol 8, iss 1
The coronavirus SARS-CoV-2 causes the severe disease COVID-19. SARS-CoV-2 infection is initiated by interaction of the viral spike protein and host receptor angiotensin-converting enzyme 2 (ACE2). We report an improved bright and reversible fluorogen
Publikováno v:
Journal of Bioscience and Bioengineering. 123:272-276
Fluorescence-based biosensor probes, especially those based on Förster resonance energy transfer (FRET) between fluorescent protein (FP) variants, are widely used to monitor various biological phenomena, often detecting ligand-induced association of
Autor:
Hiroshi Kimura, Chan-I Chung, Hitoshi Kurumizaka, Yuki Ohmuro-Matsuyama, Hiroshi Ueda, Shinichi Machida, Yuko Sato
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
Post-translational histone modifications are major regulators of gene expression. However, conventional immunoassays do not provide sufficient information regarding their spatial and temporal dynamic changes. Fluorescence/Förster resonance energy tr
Demonstration of protein-fragment complementation assay using purified firefly luciferase fragments.
Publikováno v:
BMC Biotechnology. 2013, Vol. 13 Issue 1, p1-9. 9p. 1 Diagram, 5 Graphs.
Publikováno v:
Polymer Engineering & Science. 42:654-662
The flow of polymer melts through the clearance over a barrier flight in extruders involves high, rapidly changing shear rates. Polymer melts, being viscoelastic, are expected to exhibit a high elasticity when they flow through the clearance, so the
Publikováno v:
BMC Biotechnology
Background Human interactome is predicted to contain 150,000 to 300,000 protein-protein interactions, (PPIs). Protein-fragment complementation assay (PCA) is one of the most widely used methods to detect PPI, as well as Förster resonance energy tran
Publikováno v:
Journal of Applied Polymer Science. 59:125-137
Various types of polyethylene homopolymers and copolymers, including linear high-density polyethylene (HDPE), branched low-density polyethylene (BLDPE), poly(ethylene vinyl acetate) copolymer (EVA), heterogeneous linear poly(ethylene/α-olefin) copol
Publikováno v:
Polymer Engineering & Science; Sep2004, Vol. 44 Issue 9, p1702-1706, 5p
Publikováno v:
Journal of Applied Polymer Science. 37:1339-1349
Many polymers suffer from excessive heat generation during processing due to high viscosity, and reduction of viscosity is desired to control the melt temperature during processing. The concept of solid solvent was recently proposed based on thermall