Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Carolyn Shembrey"'
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
The protective role of Natural Killer (NK) cell tumour immunosurveillance has long been recognised in colorectal cancer (CRC). However, as most patients show limited intra-tumoral NK cell infiltration, improving our ability to identify those with hig
Externí odkaz:
https://doaj.org/article/dcbd1cafc74045d0a6e02eb99f80274f
Autor:
Emily J. Lelliott, Kelly M. Ramsbottom, Mark R. Dowling, Carolyn Shembrey, Tahereh Noori, Conor J. Kearney, Jessica Michie, Ian A. Parish, Margaret A. Jordan, Alan G. Baxter, Neil D. Young, Amelia J. Brennan, Jane Oliaro
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Cytotoxic lymphocytes are essential for anti-tumor immunity, and for effective responses to cancer immunotherapy. Natural killer cell granule protein 7 (NKG7) is expressed at high levels in cytotoxic lymphocytes infiltrating tumors from patients trea
Externí odkaz:
https://doaj.org/article/c8e517cb608a45a58a1cfaec14b8b317
Autor:
Carolyn Shembrey, Jai Smith, Mélodie Grandin, Nathalia Williams, Hyun-Jung Cho, Christina Mølck, Corina Behrenbruch, Benjamin NJ. Thomson, Alexander G. Heriot, Delphine Merino, Frédéric Hollande
Publikováno v:
Cancers, Vol 14, Iss 3, p 581 (2022)
Geno- and phenotypic heterogeneity amongst cancer cell subpopulations are established drivers of treatment resistance and tumour recurrence. However, due to the technical difficulty associated with studying such intra-tumoural heterogeneity, this phe
Externí odkaz:
https://doaj.org/article/271ee8fcc235466b838aca3688212920
Publikováno v:
Cancers, Vol 11, Iss 9, p 1217 (2019)
Metastatic tumors are the primary cause of cancer-related mortality. In recent years, interest in the immunologic control of malignancy has helped establish escape from immunosurveillance as a critical requirement for incipient metastases. Our improv
Externí odkaz:
https://doaj.org/article/8f386218c21a467f84aba16264656ecd
Autor:
Alexander G. Heriot, Laura M. Beyit, Sophie Paquet-Fifield, Benjamin N. J. Thomson, Corina Behrenbruch, Yuan Cao, Jai Smith, Frédéric Hollande, Yan Qin, Carolyn Shembrey
Publikováno v:
Cancer Letters. 476:161-169
Remodeling of basement membrane proteins contributes to tumor progression towards the metastatic stage. One of these proteins, laminin 521 (LN521), sustains embryonic and induced pluripotent stem cell self-renewal, but its putative role in cancer is
Publikováno v:
Cancers, Vol 11, Iss 9, p 1217 (2019)
Cancers
Cancers
Metastatic tumors are the primary cause of cancer-related mortality. In recent years, interest in the immunologic control of malignancy has helped establish escape from immunosurveillance as a critical requirement for incipient metastases. Our improv
Autor:
Gareth P. Gregory, Carolyn Shembrey, Izabela Todorovski, Ricky W. Johnstone, Thomas Abrehart, Giovanna Pomilio, Kristin K. Brown, Emily Gruber, Andrew H. Wei, Stefan Bjelosevic, Andrea Newbold, Stephin J. Vervoort
Publikováno v:
Experimental Hematology. 88:S37-S38
Mutations in the FMS-like tyrosine kinase 3 (FLT3) gene occur in approximately 30% of all acute myeloid leukaemias (AMLs) and are associated with poor prognosis. The clinical utility of FLT3 inhibitor monotherapy has been limited by the rapid develop
Autor:
Christina Mølck, Alexander G. Heriot, Sophie Paquet-Fifield, Benjamin N. J. Thomson, Hyun-Jung Cho, Corina Behrenbruch, Carolyn Shembrey, Frédéric Hollande, Michael Michael
Publikováno v:
Clinicalexperimental metastasis. 35(4)
Surgery remains the curative treatment modality for colorectal cancer in all stages, including stage IV with resectable liver metastasis. There is emerging evidence that the stress response caused by surgery as well as other perioperative therapies s