Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Carol A. de la Motte"'
Autor:
Eric B. Nonnecke, Patricia A. Castillo, Amanda E. Dugan, Faisal Almalki, Mark A. Underwood, Carol A. De La Motte, Weirong Yuan, Wuyuan Lu, Bo Shen, Malin E. V. Johansson, Laura L. Kiessling, Edward J. Hollox, Bo Lönnerdal, Charles L. Bevins
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Intelectins are ancient carbohydrate binding proteins, spanning chordate evolution and implicated in multiple human diseases. Previous GWAS have linked SNPs in ITLN1 (also known as omentin) with susceptibility to Crohn's disease (CD); howeve
Externí odkaz:
https://doaj.org/article/a9f7b8fb0d704bc08db78ccd4cacb4d3
Autor:
Yeojung Kim, Carol A. de la Motte
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Hyaluronan (HA) is best known as an abundantly present extracellular matrix component found throughout the body of all vertebrates, including humans. Recent evidence, however, has demonstrated benefits of providing HA exogenously as a therapeutic mod
Externí odkaz:
https://doaj.org/article/c95ae5e32a5b4c58b08b1db74c8d1c63
Autor:
Artin Soroosh, Sami Albeiroti, Gail A. West, Belinda Willard, Claudio Fiocchi, Carol A. de la Motte
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 2, Iss 3, Pp 358-368.e4 (2016)
Background & Aims: Crohnâs Disease (CD) is a chronic inflammatory disease of the gastrointestinal tract. Fibrosis, a serious complication of CD, occurs when activated intestinal fibroblasts deposit excessive amounts of extracellular matrix (ECM) in
Externí odkaz:
https://doaj.org/article/d0b57c5349f4411aa8a85190a329036f
Autor:
Carol A. de la Motte, Sean P. Kessler
Publikováno v:
International Journal of Cell Biology, Vol 2015 (2015)
Hyaluronan is an abundant extracellular matrix component prevalent in the vertebrate intestinal tract. Here we discuss what is known about hyaluronan distribution during homeostasis and inflammatory diseases of the gut and discuss ways in which this
Externí odkaz:
https://doaj.org/article/5924746485534d959b4ba6d1222a50ba
Autor:
Aaron C Petrey, Carol A. de la Motte
Publikováno v:
Frontiers in Immunology, Vol 5 (2014)
Hyaluronan (HA), a major component of the extracellular matrix (ECM), plays a key role in regulating inflammation. Inflammation is associated with accumulation and turnover of hyaluronan polymers by multiple cell types. Increasingly through the years
Externí odkaz:
https://doaj.org/article/e02d8605450849fbba751e80c7dbec12
Autor:
Jeanette Wat, Megan R. McMullen, Paramananda Saikia, Damien A Bellos, Laura E. Nagy, Carol A. de la Motte, Dhara Sharma
Publikováno v:
Alcohol Clin Exp Res
Background Specific-sized species of the carbohydrate hyaluronan elicit a variety of cellular responses mediating tissue integrity and repair, as well as regulating inflammatory responses. Orally provided hyaluronan with an average molecular weight o
Autor:
Aviv Hargil, Carol A. de la Motte, Nadine Nagy, Stephen P. Evanko, Sheri M. Krams, Irina Gurevich, Hedwich F. Kuipers, Thomas N. Wight, Quynh-Lam Tran, Robert B. Vernon, Paul L. Bollyky, Amrit Ramesh, Bryan J. Xie, Graham L. Barlow, Naomi L. Haddock, Everett Meyer, Xiangyue Zhang, Koshika Yadava, Colin A. Lester, John A. Gebe, Gernot Kaber, Xi Wang, Payton L. Marshall, Andrey V. Malkovskiy, Miles H. Linde, Hunter A. Martinez, Christiaan R. de Vries, Edgar G. Engleman
Publikováno v:
Matrix Biol
A coat of pericellular hyaluronan surrounds mature dendritic cells (DC) and contributes to cell-cell interactions. We asked whether 4-methylumbelliferone (4MU), an oral inhibitor of HA synthesis, could inhibit antigen presentation. We find that 4MU t
Autor:
Aaron C. Petrey, Laura E. Nagy, Carol A. de la Motte, Yeojung Kim, Greeshma Ray, Claudio Fiocchi, Christine McDonald, Gail West, Michelle Suzanne Longworth, Sean P. Kessler
Publikováno v:
Matrix Biology. 66:93-109
Tight junction proteins are critical in maintaining homeostatic intestinal permeability. Multiple intestinal inflammatory diseases are correlated with reduced expression of tight junction proteins. We have recently reported that oral treatment of mic
Autor:
Christine McDonald, Dana R. Obery, Craig R. Homer, Yeojung Kim, Sean P. Kessler, Carol A. de la Motte
Publikováno v:
Matrix Biology. 62:28-39
Maintaining a healthy intestinal barrier, the primary physical barrier between intestinal microbiota and the underlying lamina propria, is critical for optimal health. Epithelial integrity is essential for the prevention of the entrance of luminal co
Autor:
Paramananda Saikia, Damien Bellos, Katherine S. Pollard, Megan R. McMullen, Carol A. de la Motte, Laura E. Nagy
Publikováno v:
Hepatology. 66:602-615
Increased inflammatory signaling by Kupffer cells contributes to alcoholic liver disease (ALD). Here we investigated the impact of small, specific-sized hyaluronic acid of 35 kD (HA35) on ethanol-induced sensitization of Kupffer cells, as well as eth