Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Bradley T. Andresen"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/b8d7b8b3d3c742bf8c135626273ba80d
Autor:
Md Abdullah Shamim, Ayaz Shahid, Pabitra K. Sardar, Steven Yeung, Jeremiah Reyes, Jenny Kim, Cyrus Parsa, Robert Orlando, Jeffrey Wang, Kristen M. Kelly, Frank L. Meyskens, Bradley T. Andresen, Ying Huang
Publikováno v:
Nanomaterials, Vol 13, Iss 5, p 929 (2023)
The R-carvedilol enantiomer, present in the racemic mixture of the chiral drug carvedilol, does not bind to the β-adrenergic receptors, but exhibits skin cancer preventive activity. For skin delivery, R-carvedilol-loaded transfersomes were prepared
Externí odkaz:
https://doaj.org/article/3d025cf03a8f49b5987bc6fd3a863216
Autor:
Ayaz Shahid, Mengbing Chen, Carol Lin, Bradley T. Andresen, Cyrus Parsa, Robert Orlando, Ying Huang
Publikováno v:
Cancers, Vol 15, Iss 3, p 583 (2023)
The current study evaluated the effects of the β-blocker carvedilol on benzo(a)pyrene (B(a)P) and its active metabolite benzo(a)pyrene diol epoxide (BPDE)-induced lung toxicity, inflammation and carcinogenesis and explored the potential mechanisms.
Externí odkaz:
https://doaj.org/article/855f46154bf04520b2a3f47006c31d92
Autor:
Mengbing Chen, Md Abdullah Shamim, Ayaz Shahid, Steven Yeung, Bradley T. Andresen, Jeffrey Wang, Vijaykumar Nekkanti, Frank L. Meyskens, Kristen M. Kelly, Ying Huang
Publikováno v:
Pharmaceutics, Vol 12, Iss 12, p 1151 (2020)
The β-blocker carvedilol has been shown to prevent skin carcinogenesis in vitro and in vivo. Since systemic absorption of the β-blocker may cause cardiovascular disturbance, we developed a carvedilol loaded transfersome for skin-targeted delivery.
Externí odkaz:
https://doaj.org/article/ed49c9635b2845b5ab89447d4593eda0
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3, p 798 (2020)
The β-blocker carvedilol prevents ultraviolet (UV)-induced skin cancer, but the mechanism is unknown. Since carvedilol possesses antioxidant activity, this study investigated whether carvedilol prevents oxidative photodamage of skin, a precursor eve
Externí odkaz:
https://doaj.org/article/5003f0ff19b24e89ac1f822b4b4550ea
Autor:
Shane D Anderson, Asna Tabassum, Jae Kyung Yeon, Garima Sharma, Priscilla Santos, Tik Hang Soong, Yin Win Thu, Isaac Nies, Tomomi Kurita, Andrew Chandler, Abdelaziz Alsamarah, Rhye-Samuel Kanassatega, Yun L Luo, Wesley M Botello-Smith, Bradley T Andresen
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 11, p e1007719 (2020)
Angiotensin II type 1 receptor (AT1R) blockers (ARBs) are among the most prescribed drugs. However, ARB effectiveness varies widely, which may be due to non-synonymous single nucleotide polymorphisms (nsSNPs) within the AT1R gene. The AT1R coding seq
Externí odkaz:
https://doaj.org/article/9057f3767c6a46328700c2fefa4f9edc
Autor:
Kristan H Cleveland, Sherry Liang, Andy Chang, Kevin M Huang, Si Chen, Lei Guo, Ying Huang, Bradley T Andresen
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217038 (2019)
Carvedilol is reported to prevent cancers in humans and animal models. However, a molecular mechanism has yet to be established, and the extent to which other β-blockers are chemopreventive remains relatively unknown. A comparative pharmacological a
Externí odkaz:
https://doaj.org/article/0bd2d538206844c3a004f3bc552eb2ca
Publikováno v:
Biologics: Targets & Therapy, Vol 2008, Iss Issue 3, Pp 441-452 (2008)
Lina Nordquist1, Fredrik Palm1,2, Bradley T Andresen3,41Department of Medical Cell Biology, Division of Integrative Physiology, Uppsala University, Uppsala, Sweden; 2Georgetown University Medical Center, Department of Medicine, Division of Nephrology
Externí odkaz:
https://doaj.org/article/a05b2a93806a4164910264d420380353
Autor:
Isaac Nies, Garima Sharma, Tik Hang Soong, Tomomi Kurita, Jae Kyung Yeon, Bradley T. Andresen, Asna Tabassum, Andrew Chandler, Yin Win Thu, Shane D. Anderson, Wesley M. Botello-Smith, Priscilla Santos, Yun Luo, Abdelaziz Alsamarah, Rhye-Samuel Kanassatega
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 16, Iss 11, p e1007719 (2020)
PLoS Computational Biology, Vol 16, Iss 11, p e1007719 (2020)
Angiotensin II type 1 receptor (AT1R) blockers (ARBs) are among the most prescribed drugs. However, ARB effectiveness varies widely, which may be due to non-synonymous single nucleotide polymorphisms (nsSNPs) within the AT1R gene. The AT1R coding seq
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 3
International Journal of Molecular Sciences, Vol 21, Iss 3, p 798 (2020)
Volume 21
Issue 3
International Journal of Molecular Sciences, Vol 21, Iss 3, p 798 (2020)
The &beta
blocker carvedilol prevents ultraviolet (UV)-induced skin cancer, but the mechanism is unknown. Since carvedilol possesses antioxidant activity, this study investigated whether carvedilol prevents oxidative photodamage of skin, a precu
blocker carvedilol prevents ultraviolet (UV)-induced skin cancer, but the mechanism is unknown. Since carvedilol possesses antioxidant activity, this study investigated whether carvedilol prevents oxidative photodamage of skin, a precu