Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Antonia Follenzi"'
Autor:
Michela Milani, Cesare Canepari, Simone Assanelli, Simone Merlin, Ester Borroni, Francesco Starinieri, Mauro Biffi, Fabio Russo, Anna Fabiano, Desirèe Zambroni, Andrea Annoni, Luigi Naldini, Antonia Follenzi, Alessio Cantore
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 6, Pp 1427-1450 (2024)
Abstract Lentiviral vectors (LV) are efficient vehicles for in vivo gene delivery to the liver. LV integration into the chromatin of target cells ensures their transmission upon proliferation, thus allowing potentially life-long gene therapy followin
Externí odkaz:
https://doaj.org/article/b045f6dbf8624a8e8e0b19badc7c0b7b
Autor:
Cristina Olgasi, Alessia Cucci, Ivan Molineris, Simone Assanelli, Francesca Anselmi, Chiara Borsotti, Chiara Sgromo, Andrea Lauria, Simone Merlin, Gillian E. Walker, Salvatore Oliviero, Antonia Follenzi
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Not available.
Externí odkaz:
https://doaj.org/article/3779ec1e96f04c07b5a458fdad8e794f
Autor:
Ester Borroni, Chiara Borsotti, Roberta A. Cirsmaru, Vakhtang Kalandadze, Rosella Famà, Simone Merlin, Brian Brown, Antonia Follenzi
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 1, Pp 102116- (2024)
Liver sinusoidal endothelial cells (LSECs) are specialized endocytic cells that clear the body from blood-borne pathogens and waste macromolecules through scavenger receptors (SRs). Among the various SRs expressed by LSECs is stabilin-2 (STAB2), a cl
Externí odkaz:
https://doaj.org/article/b6e9ca40771d47899d8ded40a77f5a0f
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Hemostasis is a sophisticated sequence of events aimed to repair vessel injury. This process occurs in combination with angiogenesis, which leads to new blood vessel formation helping in the wound repair and facilitating tissue healing. The fine mech
Externí odkaz:
https://doaj.org/article/cd42ccf125d54646adce15b5ad0928b4
Autor:
Nausicaa Clemente, Simona Baroni, Simone Fiorilla, Francesco Tasso, Simone Reano, Chiara Borsotti, Maria Rosaria Ruggiero, Elisa Alchera, Marco Corrazzari, Gillian Walker, Antonia Follenzi, Simonetta Geninatti Crich, Rita Carini
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)
Abstract Pharmacological treatments for advanced hepatocellular carcinoma (HCC) have a partial efficacy. Augmented Na+ content and water retention are observed in human cancers and offer unexplored targets for anticancer therapies. Na+ levels are eva
Externí odkaz:
https://doaj.org/article/7b9e3af363b549a185401d7669fa6d39
Autor:
Antonio Citro, Alessia Neroni, Cataldo Pignatelli, Francesco Campo, Martina Policardi, Matteo Monieri, Silvia Pellegrini, Erica Dugnani, Fabio Manenti, Maria Chiara Maffia, Libera Valla, Elisabeth Kemter, Ilaria Marzinotto, Cristina Olgasi, Alessia Cucci, Antonia Follenzi, Vito Lampasona, Eckhard Wolf, Lorenzo Piemonti
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Cell therapy for diabetes requires the combination of bioengineering and new sources of beta cells. Here, the authors report a self-assembly platform based on neonatal pig islets, human endothelial cells and native organ extracellular matrix, which i
Externí odkaz:
https://doaj.org/article/2a3c8e507cd5428db6511e1934289d0e
Autor:
Massimo R. Mannarino, Vanessa Bianconi, Giulia Scalisi, Luca Franceschini, Giorgia Manni, Alessia Cucci, Francesco Bagaglia, Giulia Mencarelli, Francesco Giglioni, Doriana Ricciuti, Filippo Figorilli, Benedetta Pieroni, Elena Cosentini, Eleonora Padiglioni, Cecilia Colangelo, Dietmar Fuchs, Paolo Puccetti, Antonia Follenzi, Matteo Pirro, Marco Gargaro, Francesca Fallarino
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundChronic systemic inflammation reduces the bioavailability of circulating endothelial progenitor cells (EPCs). Indoleamine 2,3-dioxygenase 1 (IDO1), a key enzyme of immune tolerance catalyzing the initial step of tryptophan degradation along
Externí odkaz:
https://doaj.org/article/e0038b3f27ff43599e3454e2cc25ae8e
Autor:
Michela Milani, Cesare Canepari, Tongyao Liu, Mauro Biffi, Fabio Russo, Tiziana Plati, Rosalia Curto, Susannah Patarroyo-White, Douglas Drager, Ilaria Visigalli, Chiara Brombin, Paola Albertini, Antonia Follenzi, Eduard Ayuso, Christian Mueller, Andrea Annoni, Luigi Naldini, Alessio Cantore
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
“Lentiviral gene therapy to the liver establishes stable long-term normal to supra-normal coagulation factor VIII activity in mouse models of hemophilia A and in non-human primates, representing a potential new treatment option for people with hemo
Externí odkaz:
https://doaj.org/article/c9b97a0d651b468fbb352c8d225f07b9
Autor:
Simone Merlin, Saicharan Akula, Alessia Cottonaro, Tamara Garcia-Leal, Luis Javier Serrano, Ester Borroni, Vakhtang Kalandadze, Rocio Galiano, Chiara Borsotti, Antonio Liras, María José Sanchez, Antonia Follenzi
Publikováno v:
Haematologica, Vol 108, Iss 6 (2023)
Hemophilia A (HA) cell therapy approaches in pediatric individuals require suitable factor (F)VIII-producing cells for stable engraftment. Liver sinusoidal endothelial cells (LSEC) and hematopoietic stem cells (HSC) have been demonstrated to be suita
Externí odkaz:
https://doaj.org/article/c6205903444a4a879ca23e2d551a8220
Autor:
Cristina Olgasi, Chiara Borsotti, Simone Merlin, Thorsten Bergmann, Patrick Bittorf, Adeolu Badi Adewoye, Nicholas Wragg, Kelcey Patterson, Andrea Calabria, Fabrizio Benedicenti, Alessia Cucci, Alessandra Borchiellini, Berardino Pollio, Eugenio Montini, Delfina M. Mazzuca, Martin Zierau, Alexandra Stolzing, Philip.M. Toleikis, Joris Braspenning, Antonia Follenzi
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 551-566 (2021)
Hemophilia A (HA) is a rare bleeding disorder caused by deficiency/dysfunction of the FVIII protein. As current therapies based on frequent FVIII infusions are not a definitive cure, long-term expression of FVIII in endothelial cells through lentivir
Externí odkaz:
https://doaj.org/article/7a58ac952d7247cb827b394f9103e931