Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Angelo M. De Marzo"'
Autor:
Joakin O. Mori, Elizabeth A. Platz, Jiayun Lu, Alexandria Brame, Misop Han, Corinne E. Joshu, Angelo M. De Marzo, Alan K. Meeker, Christopher M. Heaphy
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
BackgroundTelomeres are located at chromosomal termini and function to maintain genomic integrity. Telomere dysfunction is a well-recognized contributor to aging and age-related diseases, such as prostate cancer. Since telomere length is highly herit
Externí odkaz:
https://doaj.org/article/320c4606921c4c48b2696c1f46557873
Autor:
Tesa M. Severson, Yanyun Zhu, Angelo M. De Marzo, Tracy Jones, Jonathan W. Simons, William G. Nelson, Srinivasan Yegnasubramanian, Matthew L. Freedman, Lodewyk Wessels, Andries M. Bergman, Michael C. Haffner, Wilbert Zwart
Publikováno v:
Molecular Oncology, Vol 15, Iss 7, Pp 1942-1955 (2021)
The epigenomic regulation of transcriptional programs in metastatic prostate cancer is poorly understood. We studied the epigenomic landscape of prostate cancer drivers using transcriptional profiling and ChIP‐seq in four clonal metastatic tumors d
Externí odkaz:
https://doaj.org/article/56b5db94e7bb424f9f026fc02defd139
Autor:
Samuel R. Denmeade, Laura A. Sena, Jun Luo, Mark C. Markowski, Angelo M. De Marzo, Sushant Kachhap, Emmanuel S. Antonarakis
Publikováno v:
Clin Genitourin Cancer
Bipolar androgen therapy (BAT) is a novel treatment strategy for patients with metastatic castration-resistant prostate cancer (mCRPC). We retrospectively identified patients with mCRPC that achieved deep PSA responses to BAT. All patients with avail
Autor:
Srinivasan Yegnasubramanian, Jonathan W. Simons, William G. Nelson, Michael C. Haffner, Andries M. Bergman, Lodewyk F. A. Wessels, Tesa M. Severson, Matthew L. Freedman, Wilbert Zwart, Tracy Jones, Yanyun Zhu, Angelo M. De Marzo
Publikováno v:
Molecular Oncology, Vol 15, Iss 7, Pp 1942-1955 (2021)
Molecular Oncology
Molecular Oncology, 15(7), 1942-1955. Elsevier
Molecular Oncology
Molecular Oncology, 15(7), 1942-1955. Elsevier
The epigenomic regulation of transcriptional programs in metastatic prostate cancer is poorly understood. We studied the epigenomic landscape of prostate cancer drivers using transcriptional profiling and ChIP‐seq in four clonal metastatic tumors d
Autor:
Lorelei A. Mucci, Alan K. Meeker, Edward Giovannucci, Meir J. Stampfer, Reza Zarinshenas, Angelo M. De Marzo, Elizabeth A. Platz, Misop Han, Tamara L. Lotan, Christine Davis, Corinne E. Joshu, Jiayun Lu, John R. Barber, Christopher M. Heaphy
Publikováno v:
The journal of pathology. Clinical research. 8(5)
PurposeCurrent biomarkers are inadequate prognostic predictors in localized prostate cancer making treatment decision-making challenging. Previously, we observed that the combination of more variable telomere length among prostate cancer cells and sh
Autor:
Zhongyuan Zhang, W. Nathaniel Brennen, Angelo M. De Marzo, Alexandria Brame, Levent Trabzonlu, Sarah R. Amend, Denis Wirtz, Timothy E. G. Krueger, Ashley Kiemen, Amber E. de Groot, Kayla V. Myers, Kenneth J. Pienta, Vicente E Torres, Natalia H Nagy
Publikováno v:
Prostate
Background Tumor-associated macrophages (TAMs) are critical components of the tumor microenvironment (TME) in prostate cancer. Commonly used orthotopic models do not accurately reflect the complete TME of a human patient or the natural initiation and
Autor:
David Lim, Mindy K. Graham, Eva Corey, Tamara L. Lotan, Jonathan I. Epstein, Alan K. Meeker, Christopher M. Heaphy, Hao Wang, Mario A. Eisenberger, Angelo M. De Marzo, Christine Davis, Michael C. Haffner
Publikováno v:
Hum Pathol
BACKGROUND: Small cell neuroendocrine carcinoma (SCNC) of the prostate is an aggressive subtype with frequent TP53 mutation and RB1 inactivation, however the molecular phenotype remains an area of investigation. Here, we compared telomere lengths in
Autor:
Angelo M. De Marzo, Howard L. Parnes, Bora Gurel, M. Scott Lucia, Scott M. Lippman, Phyllis J. Goodman, Elizabeth A. Platz, John R. Barber, Frank Z. Stanczyk, William G. Nelson, Susan Chadid, Ian M. Thompson
Publikováno v:
Prostate
Background Intraprostatic inflammation is an emerging prostate cancer risk factor. Estrogens are pro-inflammatory while androgens are anti-inflammatory. Thus, we investigated whether serum sex steroid hormone concentrations are associated with intrap
Autor:
David M. Esopi, Nicole Castagna, Ruedi Aebersold, Radhika A. Patel, Angelo M. De Marzo, Tiannan Guo, Gunes Guner, Harrison Tsai, Michael C. Haffner, Jessica Hicks, Ajay Vaghasia, William G. Nelson, Nicolas Wyhs, Jin-Yih Low, Minh-Tam Pham, Srinivasan Yegnasubramanian, Akshay Bhamidipati
Publikováno v:
The Prostate, 81 (15)
Prostate
Prostate
Background Resistance to androgen deprivation therapies is a major driver of mortality in advanced prostate cancer. Therefore, there is a need to develop new preclinical models that allow the investigation of resistance mechanisms and the assessment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2ea4aa79165fe7e890ad85bb58beed2
https://hdl.handle.net/20.500.11850/501735
https://hdl.handle.net/20.500.11850/501735
Autor:
Jessica L. Hicks, Tamara L. Lotan, Angelo M. De Marzo, Ayanna M Carter, Lauren B. Peiffer, Luke Mummert, Rebecca Y Sosa, Jiayun Lu, Corinne E. Joshu, Karen S. Sfanos, Ryan Kempski, Igor Vidal, Tamirat Ali, Janielle P. Maynard
Publikováno v:
J Pathol
Prostate cancer (PCa) remains a leading cause of cancer-related deaths in American men and treatment options for metastatic PCa are limited. There is a critical need to identify new mechanisms that contribute to PCa progression, that distinguish beni