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of 10
pro vyhledávání: '"Thomas C. Foster"'
Autor:
Marcelo Febo, Luis M. Colon-Perez, Thomas C. Foster, Jolie D. Barter, Ashok V. Kumar, Asha Rani
Publikováno v:
Molecular Neurobiology. 57:4045-4059
Markers of brain aging and cognitive decline are thought to be influenced by peripheral inflammation. This study compared the effects of repeated lipopolysaccharide (LPS) treatment in young rats to age-related changes in hippocampal-dependent cogniti
Autor:
Ling Jin, Brenna L Brim, N.M. Ellinwood, R. Haskell, Kathy R. Magnusson, Arvind Kumar, Thomas C. Foster, R. Awedikian
Publikováno v:
Behavioural Brain Research. 238:211-226
The GluN2B subunit of the N-methyl-D-aspartate (NMDA) receptor shows age-related declines in expression across the frontal cortex and hippocampus. This decline is strongly correlated to age-related memory declines. This study was designed to determin
Autor:
Brandi K. Ormerod, Jessica M. Pastoriza, Rachel B. Speisman, Jamie E. Severance, Asha Rani, Ashok Kumar, Thomas C. Foster
Publikováno v:
Neurobiology of Aging. 34:263-274
Strategies combatting cognitive decline among the growing aging population are vital. We tested whether environmental enrichment could reverse age-impaired rapid spatial search strategy acquisition concomitantly with hippocampal neurogenesis in rats.
Autor:
Thomas C. Foster, Ashok Kumar
Publikováno v:
Neurobiology of Learning and Memory. 87:522-535
The current study employed aged and young male Fischer 344 rats to examine the relationship between long-term depression (LTD), age, and memory. Memory performance was measured on two tasks that are sensitive to hippocampal function; inhibitory avoid
Autor:
Ivan Usynin, Rattanavijit Vijitruth, Georgy Bakalkin, Dong-Young Choi, James Masse, Thomas C. Foster, Cynthia Kulik, Ashok V. Kumar, Guoying Bing, Mei Liu, Xuan V. Nguyen
Publikováno v:
Behavioural Brain Research. 161:254-262
Dynorphins, endogenous kappa-opioid agonists widely expressed in the central nervous system, have been reported to increase following diverse pathophysiological processes, including excitotoxicity, chronic inflammation, and traumatic injury. These pe
Publikováno v:
Hormones and Behavior. 34:163-170
This study investigated the role of the estrogen receptor alpha (ERalpha) in mediating performance on a spatial discrimination task, the Morris water maze. Spatial discrimination on this water escape task was examined in eight groups of gonadectomize
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51385 (2012)
PLoS ONE
PLoS ONE
We previously demonstrated that aged ovariectomized rats that had received prior estradiol treatment in middle-age exhibited increased levels of estrogen receptor alpha (ERα) in the hippocampus as well as enhanced hippocampal dependent memory as com
Publikováno v:
Epilepsia. 52(12)
Developmental delay and cognitive impairment are common comorbidities in people with epilepsy associated with malformations of cortical development (MCDs). We studied cognition and behavior in an animal model of diffuse cortical dysplasia (CD), in ut
Autor:
Martha Campbell-Thompson, Thomas C. Foster, Ashok Kumar, Shoudong Li, Craig Meyers, Nicholas Muzyczka, Ke Wu, Weijun Chen, Lauren M. McIntyre, Karthik Bodhinathan
Publikováno v:
Neurobiology of learning and memory. 97(1)
We previously identified a set of 50 genes that were differentially transcribed in the hippocampal CA1 region of aged, learning-impaired rats compared to aged, superior learning animals during a Morris water maze paradigm. In the current study, we ex
Publikováno v:
Neurobiology of Aging. 33:828.e1-828.e17
Aged (20-22 months) male Fischer 344 rats were randomly assigned to sedentary (A-SED), environmentally-enriched (A-ENR), or exercise (A-EX) conditions. After 10-12 weeks of differential experience, the 3 groups of aged rats and young sedentary contro