Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Richard A, Koup"'
Autor:
Koup RA; Richard A. Koup, Barney S. Graham and Daniel C. Douek are at the Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-3017, USA., Graham BS, Douek DC
Publikováno v:
Nature reviews. Immunology [Nat Rev Immunol] 2011 Jan; Vol. 11 (1), pp. 65-70. Date of Electronic Publication: 2010 Dec 17.
Autor:
Katherine V. Houser, Edmund V. Capparelli, John R. Mascola, Britta Flach, Adrian B. McDermott, Barney S. Graham, Emily E. Coates, Richard A. Koup, Mina Nikanjam, Lucio Gama, Jerry Li, Coleen K. Cunningham, Elizabeth J. McFarland, Bob C. Lin, Julie E. Ledgerwood
Publikováno v:
Clin Pharmacol Ther
VRC01 is a first-in-class, potent, broadly neutralizing antibody that targets the CD4 binding site of gp120 on HIV-1 viruses, and is under development as a novel HIV therapeutic. This study utilized population pharmacokinetic modeling to characterize
Autor:
Constantinos Petrovas, Richard A. Koup, Guillaume Stewart-Jones, Jorge R. Almeida, Sarah Rowland-Jones, Assan Jaye, David Wolinsky, Samuel Darko, Eirini Moysi, Daniel C. Douek, Ester Gea-Mallorquí, Yanchun Peng, Tao Dong
Publikováno v:
European journal of immunologyReferences. 51(10)
The dynamics of T-cell receptor (TCR) selection in chronic HIV-1 infection, and its association with clinical outcome, is well documented for an array of MHC-peptide complexes and disease stages. However, the factors that may contribute to the select
Publikováno v:
Methods. 154:118-124
Bispecific (bs) antibodies (Abs, bsAbs) are engineered immunoglobulins that contain two different antigen-binding sites in one molecule. bsAbs can be divided in two molecular formats; the IgG-like and non-IgG like. The structural elements of each for
Autor:
Timothy J. Wilkin, Philip L. Felgner, Johannes S. Gach, Chase T. M. Anderson, Steven G. Deeks, Christine Katlama, Donald N. Forthal, Andrea Gorlani, Chad J. Achenbach, Brigitte Autran, Richard A. Koup, Emmanuel Y. Dotsey, Joseph P. Casazza, Baiba Berzins, Juan C. Becerra, Robert L. Murphy
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160341 (2016)
PLoS ONE
PloS one, vol 11, iss 8
PLoS ONE
PloS one, vol 11, iss 8
Little is known about the humoral immune response against DNA prime-recombinant adenovirus 5 (rAd5) boost HIV vaccine among HIV-infected patients on long-term suppressive antiretroviral therapy (ART). Previous studies emphasized cellular immune respo
Autor:
Richard A. Koup, Christof Geldmacher
Publikováno v:
Trends in Immunology. 33:207-214
During HIV infection, it is unclear why different opportunistic pathogens cause disease at different CD4 T cell count thresholds. Early work has shown that CD4 T cell depletion is influenced both by cellular activation status and expression of viral
Autor:
Mario Roederer, Richard A. Koup, David A. Ambrozak, Melody G. Duvall, Sarah Rowland-Jones, Assan Jaye, Melissa L. Precopio, Andrew J. McMichael, Hilton Whittle
Publikováno v:
European Journal of Immunology. 38:350-363
HIV-2 is distinguished clinically and immunologically from HIV-1 infection by delayed disease progression and maintenance of HIV-specific CD4(+) T cell help in most infected subjects. Thus, HIV-2 provides a unique natural human model in which to inve
Autor:
Chris Duffy, Bin He, Edward Koo, Robert T. Bailer, Holly Trotter, Richard A. Koup, T. Manetz, Martha Nason, Rebecca L. Sheets, Judith Stein, Charla Andrews, Phillip Gomez
Publikováno v:
Journal of Immunotoxicology
The Vaccine Research Center has developed vaccine candidates for different diseases/infectious agents (including HIV-1, Ebola, and Marburg viruses) built on an adenovirus vector platform, based on adenovirus type 5 or 35. To support clinical developm
Publikováno v:
Annual Review of Immunology. 21:265-304
▪ Abstract In the absence of antiretroviral treatment, HIV-1 establishes a chronic, progressive infection of the human immune system that invariably, over the course of years, leads to its destruction and fatal immunodeficiency. Paradoxically, whil
Autor:
Takuya Yamamoto, Richard A. Koup, Michael R. Betts, Ole Lund, Marcus Buggert, Johanna Tauriainen, Juliet Wairimu Frederiksen, Marianne Jansson, Martin A. Ivarsson, Jakob Michaëlsson, Anders Sönnerborg, Bo Hejdeman, Annika C. Karlsson
Publikováno v:
PLoS Pathogens, Vol 10, Iss 7, p e1004251 (2014)
PLoS Pathogens; 10(7), no e1004251 (2014)
PLoS Pathogens
Buggert, M, Tauriainen, J, Yamamoto, T, Frederiksen, J W, Ivarsson, M A, Michaelsson, J, Lund, O, Hejdeman, B, Jansson, M, Sonnerborg, A, Koup, R A, Betts, M R & Karlsson, A C 2014, ' T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+T Cells in HIV Infection ', P L o S Pathogens, vol. 10, no. 7, e1004251 . https://doi.org/10.1371/journal.ppat.1004251
PLoS Pathogens; 10(7), no e1004251 (2014)
PLoS Pathogens
Buggert, M, Tauriainen, J, Yamamoto, T, Frederiksen, J W, Ivarsson, M A, Michaelsson, J, Lund, O, Hejdeman, B, Jansson, M, Sonnerborg, A, Koup, R A, Betts, M R & Karlsson, A C 2014, ' T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+T Cells in HIV Infection ', P L o S Pathogens, vol. 10, no. 7, e1004251 . https://doi.org/10.1371/journal.ppat.1004251
CD8+ T cell exhaustion represents a major hallmark of chronic HIV infection. Two key transcription factors governing CD8+ T cell differentiation, T-bet and Eomesodermin (Eomes), have previously been shown in mice to differentially regulate T cell exh