Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sergio Valente"'
Autor:
Dante Rotili, Paola Vianello, Annalisa Romanelli, Stefania Vultaggio, Davide Corinti, Mario Varasi, Oronza A. Botrugno, Claudia Binda, Nicola Mautone, Sergio Valente, Anna Cappa, Antonello Mai, Clemens Zwergel, Elisabetta Di Bello, Paola Dessanti, Andrea Mattevi, Saverio Minucci, Rossella Fioravanti, Annarita Rovere, Ciro Mercurio
Publikováno v:
ChemMedChem
LSD1 is a lysine demethylase highly involved in initiation and development of cancer. To design highly effective covalent inhibitors, a strategy is to fill its large catalytic cleft by designing tranylcypromine (TCP) analogs decorated with long, hind
Autor:
Andrea Mattevi, Marcello Tortorici, Paolo Trifiro, Giuseppe Meroni, Mario Varasi, Paola Dessanti, Oronza A. Botrugno, Florian Thaler, Manuela Villa, Giuseppe Ciossani, Sergio Valente, Paola Vianello, Anna Cappa, Antonello Mai, Ciro Mercurio, Saverio Minucci
Publikováno v:
European Journal of Medicinal Chemistry. 86:352-363
Histone demethylase KDM1A (also known as LSD1) has become an attractive therapeutic target for the treatment of cancer as well as other disorders such as viral infections. We report on the synthesis of compounds derived from the expansion of tranylcy
Autor:
Claus Jacob, Denise Bagrel, Bruno Botta, Brigitte Czepukojc, Zhanjie Xu, Gilbert Kirsch, Clemens Zwergel, Peter Meiser, Rino Ragno, Alexandros Patsilinakos, Mattia Mori, Mathias Montenarh, Emilie Evain-Bana, Antonello Mai, Sergio Valente, Giulia Stazi
Publikováno v:
European journal of medicinal chemistry. 134
Cell division cycle phosphatases CDC25 A, B and C are involved in modulating cell cycle processes and are found overexpressed in a large panel of cancer typology. Here, we describe the development of two novel quinone-polycycle series of CDC25A and C
Autor:
Denyse Bagrel, Marc Diederich, Gilbert Kirsch, Patrick Chaimbault, Sergio Valente, Claudia Cerella, Emilie Bana, Mario Dicato, Estelle Sibille
Publikováno v:
Molecular Carcinogenesis. 54:229-241
Cell division cycle (CDC) 25 proteins are key phosphatases regulating cell cycle transition and proliferation by regulating CDK/cyclin complexes. Overexpression of these enzymes is frequently observed in cancer and is related to aggressiveness, high-
Autor:
Francesco Spallotta, Carlo Gaetano, Antonello Mai, Andreas M. Zeiher, Fabio Martelli, Sergio Valente, Chiara Cencioni
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 14, Iss 9, Pp 17643-17663 (2013)
International Journal of Molecular Sciences; Vol 14
International Journal of Molecular Sciences, Vol 14, Iss 9, Pp 17643-17663 (2013)
International Journal of Molecular Sciences; Vol 14
Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are availab
Autor:
Claus Jacob, Sergio Valente, Denyse Bagrel, Zhanjie Xu, Peter Meiser, Emilie Bana, Antonello Mai, Gilbert Kirsch, Clemens Zwergel, Artur M. S. Silva
Publikováno v:
European Journal of Organic Chemistry. 2013:2869-2877
The reactivity of 4-(1-butoxyvinyl)-2H-chromen-2-one (1) and (E)-4-(2-butoxyvinyl)-2H-chromen-2-one (2) as diene in thermal Diels–Alder cycloaddition reactions with several electron-poor dienophiles is reported. Among several dienophiles used in th
Autor:
Nathaniel Edward Bennett Saidu, Denyse Bagrel, Gilbert Kirsch, Sergio Valente, Mathias Montenarh, Emilie Bana
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:1584-1593
Coumarins and coumarin derivatives as well as diallyl polysulfides are well known as anticancer drugs. In order to find new drugs with anticancer activities, we combined coumarins with polysulfides in the form of di-coumarin polysulfides. These novel
Autor:
Fabio Manzo, Sergio Valente, Angela Nebbioso, Antonello Mai, Lucia Altucci, Annamaria Scognamiglio
Publikováno v:
Biochimica et Biophysica Acta-Molecular Cell Research
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2008, 1783 (10), pp.2030-8. ⟨10.1016/j.bbamcr.2008.07.007⟩
Biochimica et Biophysica Acta-Molecular Cell Research, 2008, 1783 (10), pp.2030-8. ⟨10.1016/j.bbamcr.2008.07.007⟩
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2008, 1783 (10), pp.2030-8. ⟨10.1016/j.bbamcr.2008.07.007⟩
Biochimica et Biophysica Acta-Molecular Cell Research, 2008, 1783 (10), pp.2030-8. ⟨10.1016/j.bbamcr.2008.07.007⟩
International audience; Discovered for their ability to deacetylate histones and repress transcription, HDACs are a promising target for therapy of human diseases. The class II HDACs are mainly involved in developmental and differentiation processes,
Autor:
Ilaria Cerbara, Dante Rotili, Antonello Mai, Silvio Massa, Riccardo Pezzi, Rino Ragno, Silvia Simeoni, Sergio Valente
Publikováno v:
Medicinal Research Reviews. 25:261-309
The reversible histone acetylation and deacetylation are epigenetic phenomena that play critical roles in the modulation of chromatin topology and the regulation of gene expression. Aberrant transcription due to altered expression or mutation of gene
Autor:
François Gaascht, Gilbert Kirsch, Clemens Zwergel, Antonello Mai, Sergio Valente, Marc Diederich, Michael Schnekenburger, Mario Dicato, Carole Seidel
Publikováno v:
Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2014, 24 (16), pp.3797-3801. ⟨10.1016/j.bmcl.2014.06.067⟩
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2014, 24 (16), pp.3797-3801. ⟨10.1016/j.bmcl.2014.06.067⟩
International audience; Histone deacetylases (HDACs) are well-established, promising targets for anticancer therapy due to their critical role in cancer development. Accordingly, an increasing number of HDAC inhibitors displaying cytotoxic effects ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04d1b4ec01fbb9ec38413de909f89f8
https://hal.univ-lorraine.fr/hal-01494600
https://hal.univ-lorraine.fr/hal-01494600