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Autor:
Jiarui Wang, Xianqin Zhang, Tingting Zou, Dazhi Zhang, Wenqiang Liu, Zhenxing Liu, Xuejie Peng, Zhengyi Ni, Yang Tan, Meiqi Hou, Mi Zhou, Chao Yuan, Xiaopei Zhou
Publikováno v:
Biochemical and Biophysical Research Communications. 591:124-129
Mendelian susceptibility to mycobacterial disease (MSMD) is a rare monogenetic disease, which is characterized by susceptibility to some weakly virulent mycobacteria. Here, we explored the pathogenic genes and molecular mechanisms of MSMD patients. W
Publikováno v:
Molecular Immunology. 141:1-12
Cryptocaryon irritans, a holotrichous ciliate parasitic protozoan, can trigger marine white spot disease and cause substantial economic losses in mariculture. However, methods of preventing and curing the disease have negatively affect fish, human, o
Autor:
Masa-Aki Ikeda, Khandakar A.S.M. Saadat, Zekiye Altan, Cuneyd Parlayan, Kaifee Arman, Yunus Sahin
Publikováno v:
Biochemical and Biophysical Research Communications. 585:89-95
Osteosarcoma (OS) is the most common primary malignant bone tumor which has unclear pathobiology. Hence, enlightening the exact molecular mechanism underlying osteosarcoma progression is crucial for developing new treatment strategies. One member of
Autor:
Takatoshi Hikida, Hiroshi Shiraishi, Minoru Fujiki, Takashi Kobayashi, Hiroyuki Fujinami, Ikuko Morisaki, Josef M. Penninger, Toshikatsu Hanada, Reiko Hanada, Nobuyuki Shimizu, Yuji Arai
Publikováno v:
Biochemical and Biophysical Research Communications. 570:60-66
Cleavage factor polyribonucleotide kinase subunit 1 (CLP1), an RNA kinase, plays essential roles in protein complexes involved in the 3'-end formation and polyadenylation of mRNA and the tRNA splicing endonuclease complex, which is involved in precur
Autor:
Ke Li
Publikováno v:
Biochemical and Biophysical Research Communications. 570:175-183
Background The overarching goal of this research was to identify the effect of miR-509-3-5p on colon cancer (CC) and its interaction with potential target gene GTSE1 in CC. Methods The miR-509-3-5p expression was ascertained after performing qRT-PCR
Autor:
Maryam Rasoulinezhad, Morteza Heidari, Masoud Garshasbi, Erfan Heidari, Ali Reza Tavasoli, Brenda Banwell, Neda Pak, Mahmoud Reza Ashrafi
Publikováno v:
Mitochondrion. 60:12-20
Complex III (CIII) is the third out of five mitochondrial respiratory chain complexes residing at the mitochondrial inner membrane. The assembly of 10 subunits encoded by nuclear DNA and one by mitochondrial DNA result in the functional CIII which tr
Autor:
Teresa Cristina Cardoso Fonseca, Patrizia Larghero, Regiana Quinto de Souza, Lisandro Ribeiro, Carmen Bonfim, Francianne Gomes Andrade, Ingrid Sardou-Cezar, Teresa de Souza Fernandez, Bruno Almeida Lopes, Maria S. Pombo-de-Oliveira, Gisele Loth, Rolf Marschalek, Claus Meyer, Elissa Santos Morgado
Publikováno v:
Cancer Genetics. :86-90
Therapy-related acute myeloid leukemia (t-AML) following treatment with topoisomerase-II inhibitors has been increasingly reported. These compounds (e.g. etoposide) promote DNA damage and are associated with KMT2A rearrangements. They are widely used
Autor:
Takahisa Kawamura, Motohiro Tamiya, Keiichiro Honma, Shingo Matsumoto, Fumio Imamura, Kei Kunimasa, Kazumi Nishino, Yoji Kukita, Toru Kumagai, Naotoshi Sugimoto, Tomoyuki Yamasaki, Koichi Goto, Takako Inoue, Hayato Kawachi
Publikováno v:
Cancer Genetics. :57-61
The EGFR-A763_Y764insFQEA is a unique mutation among EGFR exon 20 insertion mutations in that it is associated with sensitivity to conventional EGFR-tyrosine kinase inhibitors. This mutation, which was not initially covered by conventional reverse tr
Publikováno v:
Cancer Genetics. :81-85
Low-grade endometrial stromal sarcoma and ossifying fibromyxoid tumors are two types of mesenchymal tumors that share no similarities in terms of site, sex, and morphological characteristics. They are rare, low grade tumors of uncertain lineage, with
Publikováno v:
Cancer Genetics. :62-67
MET exon 14 skipping (METex14) is a validated oncogenic driver in lung cancer and MET tyrosine kinase inhibitors are now available as effective clinical treatments. The majority of known METex14 alterations are typical donor/acceptor splicing or ubiq