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Autor:
Jessica B Jordan, Louis S. Matza, Kirsi Norrbacka, Kristina S. Boye, Luis-Emilio Garcia-Perez, Ren Yu, Syed Wasi Hassan, Dara Stein
Publikováno v:
Drugs in R&D
Drugs in R&D, Vol 19, Iss 2, Pp 213-225 (2019)
Drugs in R&D, Vol 19, Iss 2, Pp 213-225 (2019)
Introduction Patients with type 2 diabetes mellitus (T2DM) who fail to meet glycaemic control are at increased risk of diabetes complications. For patients who cannot maintain glycaemic control with oral medication, one recommended option is to add a
Autor:
María Isabel Vargas, Rafael Salazar, Julia Ferreras, Francisco Rodelas, Jordi Guitart, Vicente De Sanctis, Joan Coma, Pere Estivill, Almudena Sanz, Jordi Moya, Albert Tomás, José Fuentes, Antonio Javier Jiménez, Jordi Folch
Publikováno v:
Drugs in R&D
Objective Our objective was to assess the effect of sublingual fentanyl tablets (SFTs) on pain relief, quality of life, and adverse effects in patients with cancer pain, according to cancer stage and background opioid regimen. Methods Subgroup analys
Publikováno v:
Drugs in R&D
Background and Aims Fasiglifam, a potent, selective novel agonist of G protein-coupled receptor 40, stimulates insulin secretion at elevated blood glucose levels in a glucose-dependent manner. This study evaluated the potential effect of hepatic impa
Autor:
Mitsuyoshi Namba, Masayuki Miuchi, Yoshiki Kusunoki, Tomoyuki Katsuno, Kazuki Murai, Toshihiro Matsuo, Jun-ichiro Miyagawa, Fumihiro Ochi, Masaru Tokuda
Publikováno v:
Drugs in R&D
Background Sitagliptin inhibits dipeptidyl peptidase-4, which inactivates the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide. To assess its antidiabetic potency, we used meal tolerance tests (MTTs)
Publikováno v:
Drugs in R&D
Background Many physicians consider platinum-doublet chemotherapy inappropriate for elderly patients, regardless of their medical fitness. Objective This was a retrospective subgroup analysis of data from a multicenter, randomized, phase III clinical
Autor:
Mohammad Ali Broumand, Yaser Jenab, Farzad Darabi, Hossein Khalili, Mojtaba Salarifar, Azita Hajhossein Talasaz
Publikováno v:
Drugs in R&D
Background and Aims Ischemia following acute myocardial infarction (AMI) increases the level of pro-fibrotic and inflammatory cytokines, including transforming growth factor (TGF)-β and tumor necrosis factor (TNF)-α. N-acetylcysteine (NAC) has ther