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Autor:
Ying-Ying Liang, Fei-Yu Niu, An-An Xu, Li-Li Jiang, Chun-shan Liu, Hui-ping Liang, Yu-Fan Huang, Xun-Fan Shao, Zhi-Wen Mo, Ya-Wei Yuan
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-10 (2022)
Worldwide, nasopharyngeal carcinoma (NPC) is a rare head and neck cancer; however, it is a common malignancy in southern China. Radiotherapy is the most important treatment strategy for NPC. However, although radiotherapy is a strong tool to kill can
Blockade of caspase cascade overcomes malaria-associated acute respiratory distress syndrome in mice
Autor:
Michelle K. Sercundes, Luana S. Ortolan, Viviane da Silva Julio, Leonardo M. Bella, Thatyane de Castro Quirino, Daniela Debone, Marcela S. Carneiro-Ramos, Marcelo A. Christoffolete, Joilson O. Martins, Maria Regina D’Império Lima, José M. Alvarez, Gustavo P. Amarante-Mendes, Lígia Antunes Gonçalves, Claudio R. F. Marinho, Sabrina Epiphanio
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-10 (2022)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Malaria is an enormous burden on global health that caused 409,000 deaths in 2019. Severe malaria can manifest in the lungs, an illness known as acute respiratory distress syndrome (ARDS). Not much is known about the development of malaria-associated
Autor:
Danyang Shi, Jinhua Ding, Shouqiang Xie, Lei Huang, Hongmin Zhang, Xiaojie Chen, Xuejun Ren, Sa Zhou, Hongpeng He, Wenjian Ma, Tongcun Zhang, Nan Wang
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-11 (2022)
Upon vascular injury, vascular smooth muscle cells (VSMCs) change from a contractile phenotype to a synthetic phenotype, thereby leading to atherogenesis and arterial restenosis. Myocardin (MYOCD) is essential for maintaining the contractile phenotyp
Autor:
Yasunari Fukuda, Matias A. Bustos, Sung-Nam Cho, Jason Roszik, Suyeon Ryu, Victor M. Lopez, Jared K. Burks, Jeffrey E. Lee, Elizabeth A. Grimm, Dave S. B. Hoon, Suhendan Ekmekcioglu
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-11 (2022)
Soluble forms of receptors play distinctive roles in modulating signal-transduction pathways. Soluble CD74 (sCD74) has been identified in sera of inflammatory diseases and implicated in their pathophysiology; however, few relevant data are available
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-12 (2022)
Diacylglycerol kinase ζ (DGKZ) is a diacylglycerol kinase that metabolizes diacylglycerol to yield phosphatidic acid, and its function in breast cancer progression remains unclear. In this study, via screening of a CRISPR-Cas9 knockout library conta
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-11 (2022)
The exact pathogenesis of inflammatory bowel disease (IBD), a chronic gastrointestinal inflammatory disease comprising Crohn’s disease and ulcerative colitis, remains unclear. Studies on ubiquitination, which regulates the degradation of inflammati
Autor:
Violette Azzoni, Julien Wicinski, Manon Macario, Martin Castagné, Pascal Finetti, Katerina Ambrosova, Célia D. Rouault, Arnaud Sergé, Anne Farina, Emilie Agavnian, Sergiu Coslet, Emmanuelle Josselin, Arnaud Guille, José Adelaide, Emmanouil Zacharioudakis, Rémy Castellano, Francois Bertucci, Daniel Birnbaum, Raphael Rodriguez, Emmanuelle Charafe-Jauffret, Christophe Ginestier
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-15 (2022)
Cell Death and Disease
Cell Death and Disease, 2022, 13 (2), pp.96. ⟨10.1038/s41419-022-04538-w⟩
Cell Death and Disease
Cell Death and Disease, 2022, 13 (2), pp.96. ⟨10.1038/s41419-022-04538-w⟩
Replication stress (RS) has a pivotal role in tumor initiation, progression, or therapeutic resistance. In this study, we depicted the mechanism of breast cancer stem cells’ (bCSCs) response to RS and its clinical implication. We demonstrated that
Autor:
Zhiling Zhou, Jiaxin Zhan, Qiong Luo, Xinghua Hou, Shuxia Wang, Dingzhang Xiao, Zhi Xie, Haidan Liang, Shuguang Lin, Meng Zheng
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-10 (2022)
Metastatic tumors are mainly composed of neoplastic cells escaping from the primary tumor and inflammatory cells egressing from bone marrow. Cancer cell and inflammatory cell are remained in the state of immaturity during migration to distant organs.
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-13 (2022)
Innate radioresistance substantially limits the effectiveness of radiotherapy for colorectal cancer (CRC); thus, a strategy to enhance the radiosensitivity of CRC is urgently needed. Herein, we reported that ankyrin repeat and KH domain containing 1
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-14 (2022)
Breast cancer is the most common malignancy among women across the globe. Recent studies have revealed that many long non-coding RNAs (lncRNAs) regulate the Wnt/β-catenin signaling pathway in several types of cancer. Hyperactivation of the Wnt/β-ca