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Autor:
Paulina Koczurkiewicz-Adamczyk, Pawel E. Ferdek, Elżbieta Pękala, Reinoud Gosens, Agnieszka Jankowska, Grażyna Chłoń-Rzepa, Artur Świerczek, Elżbieta Wyska, Krzysztof Pociecha, Marietta Ślusarczyk, Katarzyna Wójcik-Pszczoła, Agnieszka A. Kusiak
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 11
International Journal of Molecular Sciences, 21(11):4008. MDPI AG
International Journal of Molecular Sciences, Vol 21, Iss 4008, p 4008 (2020)
Volume 21
Issue 11
International Journal of Molecular Sciences, 21(11):4008. MDPI AG
International Journal of Molecular Sciences, Vol 21, Iss 4008, p 4008 (2020)
Phosphodiesterase (PDE) inhibitors are currently a widespread and extensively studied group of anti-inflammatory and anti-fibrotic compounds which may find use in the treatment of numerous lung diseases, including asthma and chronic obstructive pulmo
Autor:
Nipon Chattipakorn, Siriporn C. Chattipakorn, Salinee Jantrapirom, Woorawee Inthachat, Piyarat Govitrapong, Piya Temviriyanukul, Saranyapin Potikanond, Wutigri Nimlamool
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1725 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 5
International Journal of Molecular Sciences
Volume 21
Issue 5
Neuronal insulin resistance is a significant feature of Alzheimer&rsquo
s disease (AD). Accumulated evidence has revealed the possible neuroprotective mechanisms of antidiabetic drugs in AD. Liraglutide, a glucagon-like peptide-1 (GLP-1) analog
s disease (AD). Accumulated evidence has revealed the possible neuroprotective mechanisms of antidiabetic drugs in AD. Liraglutide, a glucagon-like peptide-1 (GLP-1) analog
Autor:
Débora Mena, Maria S. Santos, Inês N Alves, Elisa J. Campos, Daniela F Silva, Ana I. Duarte, Paula I. Moreira, Catarina R. Oliveira, Nuno J. Machado, Emanuel Candeias
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1746 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 5
International Journal of Molecular Sciences
Volume 21
Issue 5
Alzheimer&rsquo
s disease (AD) is the most common form of dementia worldwide, being characterized by the deposition of senile plaques, neurofibrillary tangles (enriched in the amyloid beta (A&beta
) peptide and hyperphosphorylated tau (p-ta
s disease (AD) is the most common form of dementia worldwide, being characterized by the deposition of senile plaques, neurofibrillary tangles (enriched in the amyloid beta (A&beta
) peptide and hyperphosphorylated tau (p-ta
Autor:
Haruka Kogiso, Yoshinori Marunaka, Matthieu Raveau, Toshio Inui, Shinji Asano, Tomonori Okazaki, Takashi Nakahari, Yukiko Ikeuchi, Daichi Saito, Kazuhiro Yamakawa
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 6, p 1947 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 6
International Journal of Molecular Sciences
Volume 21
Issue 6
In Ts1Rhr, a Down syndrome model mouse, the airway ciliary beatings are impaired
that is, decreases in ciliary beat frequency (CBF) and ciliary bend angle (CBA, an index of ciliary beat amplitude)). A resumption to two copies of the Pcp4 gene on
that is, decreases in ciliary beat frequency (CBF) and ciliary bend angle (CBA, an index of ciliary beat amplitude)). A resumption to two copies of the Pcp4 gene on
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 6, p 2134 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 6
International Journal of Molecular Sciences
Volume 21
Issue 6
It is well known that axial coordination of heme iron in mitochondrial cytochrome c has redox-dependent stability. The Met80 heme iron axial ligand in the ferric form of the protein is relatively labile and can be easily replaced by alternative amino
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1721 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 5
International Journal of Molecular Sciences
Volume 21
Issue 5
Non-small cell lung cancer (NSCLC) represents a difficult condition to treat, due to epidermal growth factor receptor (EGFR) kinase domain mutations, which lead to ligand-independent phosphorylation. Deletion of five amino acids (ELREA) in exon 19 an
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 4, p 1365 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 4
International Journal of Molecular Sciences
Volume 21
Issue 4
The major cat allergen Fel d 1 is a tetrameric glycoprotein of the secretoglobin superfamily. Structural aspects and allergenic properties of this protein have been investigated, but its physiological function remains unclear. Fel d 1 is assumed to b
Autor:
Naotoshi Sugimoto, Osamu Shido, Emon Hossain, Eri Sumiyoshi, Kentaro Matsuzaki, Masanori Katakura, Rafiad Islam
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3, p 815 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 3
International Journal of Molecular Sciences
Volume 21
Issue 3
Salivary immunoglobulin A (IgA) plays a critical role in mucosal immunity. Chronic exposure to moderate heat induces heat acclimation, which modifies salivary functions. However, the changes in salivary IgA secretion in heat-acclimated rats are uncle
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3, p 725 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Anemia is frequently observed in the course of chronic kidney disease (CKD) and it is associated with diminishing the quality of a patient’s life. It also enhances morbidity and mortality and hastens the CKD progression rate. Patients with CKD freq
Autor:
Csaba Hetényi, Kálmán Hideg, Nikolett Erős, Miklós Poór, Violetta Mohos, Balázs Bognár, Masaki Nagane, Tamás Kálai, Eszter Fliszár-Nyúl, Balázs Zoltán Zsidó, Mária Balog
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 2, p 508 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 2
International Journal of Molecular Sciences
Volume 21
Issue 2
Bergamottin (BM, 1), a component of grapefruit juice, acts as an inhibitor of some isoforms of the cytochrome P450 (CYP) enzyme, particularly CYP3A4. Herein, a new bergamottin containing a nitroxide moiety (SL-bergamottin, SL-BM, 10) was synthesized<