Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Hideo Araki"'
Publikováno v:
Alimentary Pharmacology & Therapeutics. 16:90-101
Background: A recent study demonstrated that inhibition of both cyclooxygenase (COX)-1 and COX-2 is required for the development of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric lesions. However, the role of COX-1 or COX-2 inhibition in
Publikováno v:
Journal of Physiology-Paris. 95:157-163
Gastrointestinal ulcerogenic effect of indomethacin is causally related with an endogenous prostaglandin (PG) deficiency, yet the detailed mechanism remains unknown. We examined the effect of various PGE analogues specific to EP receptor subtypes on
Publikováno v:
Digestive Diseases and Sciences. 46:1805-1818
The effects of a nitric oxide (NO) releasing derivative of indomethacin (NCX-530) on gastric ulcerogenic and healing responses were evaluated in rats and mice, in comparison with the parent compound indomethacin. Indomethacin (per os) produced damage
Autor:
Hidekazu Nishiwaki, Osamu Furukawa, Hideo Araki, Masakazu Umeda, Koji Takeuchi, Akinobu Fujita
Publikováno v:
Life Sciences. 65:1207-1216
Gastric mucosal blood flow (GMBF) response and the recovery of gastric mucosal integrity were investigated in anesthetized rat stomachs after damage by monochloramine (NH2Cl), in comparison with 20 mM taurocholate Na (TC). A rat stomach was mounted i
Publikováno v:
Journal of physiology, Paris. 95(1-6)
We examined the gastric ulcerogenic property of selective COX-1 and/or COX-2 inhibitors in rats, and investigated whether COX-1 inhibition is by itself sufficient for induction of gastric damage. Animals fasted for 18 h were given various COX inhibit
Autor:
Masakazu Umdeda, Keizo Suzuki, Hiroyuki Mizoguchi, Hideo Araki, Koji Takeuchi, Shinichi Sugamoto
Publikováno v:
Journal of physiology, Paris. 93(5)
We examined the roles of endogenous prostaglandins (PGs) and nitric oxide (NO) in the gastroduodenal ulcerogenic responses to hypothermic stress (28∼30 °C) in anesthetized rats. Lowering body temperature provoked damage in the gastroduodenal mucos