Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Hideo Araki"'
Publikováno v:
Alimentary Pharmacology & Therapeutics. 16:90-101
Background: A recent study demonstrated that inhibition of both cyclooxygenase (COX)-1 and COX-2 is required for the development of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric lesions. However, the role of COX-1 or COX-2 inhibition in
Publikováno v:
Life Sciences. 68:1951-1963
Body temperature dependency in gastric functional responses to baclofen, a GABA B agonist, such as acid secretion, mucosal blood flow (GMBF) and motor activity, was examined in urethane-anesthetized rats under normal (37±1 °C) and hypothermic (31±
Publikováno v:
Digestive Diseases and Sciences. 46:1805-1818
The effects of a nitric oxide (NO) releasing derivative of indomethacin (NCX-530) on gastric ulcerogenic and healing responses were evaluated in rats and mice, in comparison with the parent compound indomethacin. Indomethacin (per os) produced damage
Publikováno v:
Journal of physiology, Paris. 95(1-6)
We examined the gastric ulcerogenic property of selective COX-1 and/or COX-2 inhibitors in rats, and investigated whether COX-1 inhibition is by itself sufficient for induction of gastric damage. Animals fasted for 18 h were given various COX inhibit
Autor:
Masakazu Umdeda, Keizo Suzuki, Hiroyuki Mizoguchi, Hideo Araki, Koji Takeuchi, Shinichi Sugamoto
Publikováno v:
Journal of physiology, Paris. 93(5)
We examined the roles of endogenous prostaglandins (PGs) and nitric oxide (NO) in the gastroduodenal ulcerogenic responses to hypothermic stress (28∼30 °C) in anesthetized rats. Lowering body temperature provoked damage in the gastroduodenal mucos