Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mandy L. Ford"'
Autor:
Shunsuke Otani, Zhe Liang, John D. Lyons, Craig M. Coopersmith, Rohit Mittal, Mandy L. Ford, Nathan J. Klingensmith
Publikováno v:
The FASEB Journal. 31:5507-5519
Cell production and death are tightly regulated in the rapidly renewing gut epithelium, with proliferation confined to crypts and apoptosis occurring in villi and crypts. This study sought to determine how stress alters these compartmentalized proces
Autor:
Ronald F. Parsons, Hannah Decker, Howard M. Gebel, Harold C. Sullivan, Annette M. Jackson, Christian P. Larsen, Mandy L. Ford, Dong-Feng Chen, Shalini Bumb, Malek Kamoun, Arslan Zahid, Frances Eun-Hyung Lee, Matthew H. Levine, Thomas C. Pearson, Robert A. Bray, Idelberto R. Badell
Publikováno v:
Am J Transplant
Recent evidence suggests that belatacept reduces the durability of preexisting antibodies to class I and class II human leukocyte antigens (HLAs). In this case series of 163 highly sensitized kidney transplant candidates whose calculated panel-reacti
Autor:
Zhe Liang, Mandy L. Ford, Deena B. Chihade, Ching-Wen Chen, Nathan J. Klingensmith, Katherine T. Fay, John D. Lyons, Kimberly M. Ramonell, Craig M. Coopersmith
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0202656 (2018)
CD43 is a large transmembrane protein involved in T cell activation. Previous studies of CD43-/- mice in viral models have demonstrated a role for CD43 in Th1/Th2 skewing, activation of Foxp3+ Treg, and T cell apoptosis. However, the role of CD43 dur
Autor:
Zhe Liang, Deena B. Chihade, Craig M. Coopersmith, Kimberly M. Ramonell, Wenxiao Zhang, Ching-Wen Chen, Mandy L. Ford, Jianfeng Xie
Publikováno v:
J Leukoc Biol
Patients with cancer are at an increased risk of developing and dying from sepsis. We previously reported that blockade of the chemokine receptor CXCR4 resulted in decreased CD4+ T cell exhaustion and improved survival in a model of polymicrobial sep
Autor:
Christian P. Larsen, Mandy L. Ford, Scott M. Krummey, Aneesh K. Mehta, J. Cheeseman, Peter S. Jang, Jason A. Conger, Allan D. Kirk
Publikováno v:
American Journal of Transplantation. 14:607-614
The CD28/cytotoxic T-lymphocyte antigen 4 (CTLA-4)blocker belatacept selectively inhibits alloreactive T cell responses but is associated with a high incidence of acute rejection following renal transplantation,which led us to investigate the etiolog
Autor:
Christian P. Larsen, Mandy L. Ford, Miriam Cortes-Cerisuelo, Andrew B. Adams, Pamela D. Winterberg, David V. Mathews, Sonia J. Laurie
Publikováno v:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 17(9)
While most human T cells express the CD28 costimulatory molecule constitutively, it is well-known that age, inflammation, and viral infection can drive the generation of CD28null T cells. In vitro studies have demonstrated that CD28null cell effector
Autor:
Brian D. Evavold, Mandy L. Ford
Publikováno v:
Cellular Immunology. 240:53-61
Several recent reports have described an effector role for CD8(+) T cells during EAE. We have previously demonstrated reduced disease incidence and severity in CD43(-/-) mice following MOG immunization, and attributed this attenuation in disease prog
Autor:
Mandy L. Ford, Brian D. Evavold
Publikováno v:
European Journal of Immunology. 35:76-85
Experimental autoimmune encephalomyelitis (EAE) has traditionally been thought to be almost exclusively mediated by CD4(+) effector T cells. Here, we provide evidence for the existence of mouse CD8(+) T cells that are specific for an epitope of the m
Autor:
Brian D. Evavold, Mandy L. Ford
Publikováno v:
European Journal of Immunology. 34:388-397
Previous strategies to ameliorate experimental autoimmune encephalitis (EAE) include the treatment of autoreactive T cells with altered peptide ligands, which contain amino acid substitutions at TCR contact residues. We recently showed that a variant