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Publikováno v:
Biochemical and Biophysical Research Communications. 637:203-209
Ribosome biogenesis proceeds with the successive cleavage and trimming of the large 47S rRNA precursor, where the RNA exosome plays major roles in concert with the Ski2-like RNA helicase, MTR4. The recent finding of a consensus amino acid sequence, t
Autor:
Ke Zhao, Changli Wang, Yan Liu, Yan Li, Teng Hui, Gan Wang, Xinhui Zhang, Xiaochang Xue, Jiefang Kang, Guodong Feng
Publikováno v:
Biochemical and Biophysical Research Communications. 636:48-54
Inflammatory bowel disease (IBD) is a non-specific inflammatory disease of the intestine with the pathogenesis to be largely unknown. We found that microRNA (miR)-10b knock-out mice displayed mild IBD symptoms, suggesting that miR-10b may be involved
Autor:
Ikumi Nakashima, Shoji Saito, Eiichi Akahoshi, Shigeki Yagyu, Mitsuko Sugano-Ishihara, Yozo Nakazawa
Publikováno v:
Biochemical and Biophysical Research Communications. 635:144-153
Breast cancer is a complex heterogeneous disease with unique molecular subtypes, which limits the development of optimized treatment strategies for each subtype. Cancer gene therapy and potential therapeutics for advanced/refractory cancers can be pr
Publikováno v:
Biochemical and Biophysical Research Communications. 632:113-121
In this study, we aim to investigate the effect of metformin on cholesterol synthesis and efflux-related genes in chondrocytes during osteoarthritis (OA) and explore the underlying mechanisms. Primary chondrocytes were harvested from Wistar rat carti
Autor:
Shin Koike, Yusuke Miyaji, Kazuhiro Suzuki, Mitsuhiro Miyashita, Masanari Itokawa, Makoto Arai, Yuki Ogasawara
Publikováno v:
Biochemical and Biophysical Research Communications. 634:70-74
In this study, we measured conjugated and unconjugated free bile acids (BAs) in plasma from patients with schizophrenia and healthy subjects to examine the possibility of BA as a biomarker for schizophrenia. Although the levels of each BA conjugate s
Autor:
Ilya Bezprozvanny
Publikováno v:
Biochemical and Biophysical Research Communications. 633:72-76
Autor:
Marco A. Saraiva, M. Helena Florêncio
Publikováno v:
Biochemical and Biophysical Research Communications. 635:30-36
It is well-known that α-synuclein (Syn) protein aggregation is implicated in the pathogenesis of Parkinson's disease. There is an increased evidence that large protein aggregates populate very early the subsaturated solutions of several aggregate-pr
Publikováno v:
Biochemistry and Cell Biology. 100:473-484
Malignant melanoma is a highly aggressive cutaneous neoplasm with increasing incidence worldwide. Non-SMC condensin II complex subunit G2 (NCAPG2) exerts import biological function in the pathogenesis of several tumors. In this study, the functional
Publikováno v:
Biochemical and Biophysical Research Communications. 635:92-98
Premature ovarian failure (POF) is characterized by amenorrhea, hypoestrogenism, elevated gonadotropin levels, and infertility. Although some of previous studies reported that Mesenchymal stem cells (MSC) transplantation could rescue the ovary functi
Publikováno v:
Biochemical and Biophysical Research Communications. 636:121-124
IGF1R plays an important role in regulating cellular metabolism and cell growth, and has been identified as an anti-cancer and diabetes drug target. Although research have been reported many crystal and cryo-EM structures of IGF1R, the mechanism of l