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Autor:
Erik, Rihtar, Tina, Lebar, Duško, Lainšček, Katarina, Kores, Samo, Lešnik, Urban, Bren, Roman, Jerala
Publikováno v:
Nature Chemical Biology. 19:64-71
Chemically inducible systems represent valuable synthetic biology tools that enable the external control of biological processes. However, their translation to therapeutic applications has been limited because of unfavorable ligand characteristics or
Publikováno v:
Mitochondrion. 66:74-81
Breast cancer is the most common cancer in women worldwide. MicroRNAs (miRNAs) are non-coding RNAs that are involved in the post-transcriptional regulation of gene expression. Although miRNAs mainly act in the cytoplasm, they can be found in the mito
Publikováno v:
Trends in Cell Biology. 32:762-772
Translation factors have traditionally been viewed as proteins that drive ribosome function and ensure accurate mRNA translation. Recent discoveries have highlighted that these factors can also moonlight in gene regulation, but through functions dist
Publikováno v:
FEBS Letters. 596:1981-1993
Nuclear factor erythroid-derived 2-like 2 (NRF2) is a master transcription factor that coordinately regulates the expression of many cytoprotective genes and plays a central role in defense mechanisms against oxidative and electrophilic insults. Alth
Autor:
Andrea L. Miranda, Lucille T. Kourdova, Ana C. Racca, Mariano Cruz Del Puerto, Maria L. Rojas, Aldilane L. X. Marques, Elaine C. O. Silva, Eduardo J. S. Fonseca, Yamila Gazzoni, Adriana Gruppi, Alexandre U. Borbely, Susana Genti‐Raimondi, Graciela M. Panzetta‐Dutari
Publikováno v:
FEBS Letters. 596:1700-1719
Trophoblast cell differentiation is of paramount importance for successful pregnancy. Krüppel-like factor 6 (KLF6), a transcription factor with diverse roles in cell physiology and tumor biology, is required for trophoblast differentiation through t
Autor:
Lemei Zheng, Mengna Li, Jianxia Wei, Shipeng Chen, Changning Xue, Yuting Zhan, Yumei Duan, Hongyu Deng, Wei Xiong, Guiyuan Li, Ming Zhou
Publikováno v:
Journal of Cellular Physiology. 237:2758-2769
N6-methyladenosine (m6A) is an extremely common and conservative posttranscriptional modification, that can specifically target and regulate the expression or stability of a series of tumor-related genes, thus playing critical roles in the occurrence
Autor:
Karl-Heinz, Klempnauer
Publikováno v:
Experimental Hematology. 108:8-15
Transcription factor MYB is a key regulator of gene expression in hematopoietic cells and has emerged as a novel drug target for acute myeloid leukemia (AML). Studies aiming to identify potential MYB inhibitors have found that the natural compound he
Autor:
Zhenghua Li, Hideki Kanazashi, Yoshimi Tokashiki, Rie Fujikawa, Ayaka Okagaki, Sho Katoh, Kenta Kojima, Kyoko Haruna, Naoko Matsushita, Tomo-o Ishikawa, Hong Chen, Kenichi Yamamura
Publikováno v:
Biochemical and Biophysical Research Communications. 599:69-74
Familial amyloidotic polyneuropathy (FAP) is caused by a mutation in the transthyretin (TTR) gene. In addition, deposition of wild-type TTR can cause senile systemic amyloidosis (SSA). To date, we have produced several transgenic mouse models for FAP
Publikováno v:
Biochemical and Biophysical Research Communications. 596:63-70
Owing to lacking protective effect of estrogen, OVX mice have higher risk of non-alcoholic fatty liver disease compared with normal female mice, when fed with high fat diet. Our study was to explore how estrogen protect against nonalcoholic steatohep
Autor:
Hamidreza Zalpoor, Abdullatif Akbari, Azam Samei, Razieh Forghaniesfidvajani, Monireh Kamali, Azadeh Afzalnia, Shirin Manshouri, Fatemeh Heidari, Majid Pornour, Majid Khoshmirsafa, Hossein Aazami, Farhad Seif
Publikováno v:
Cellular & Molecular Biology Letters, Vol 27, Iss 1, Pp 1-21 (2022)
Cellular & Molecular Biology Letters
Cellular & Molecular Biology Letters
The novel coronavirus disease 2019 (COVID-19) pandemic has spread worldwide, and finding a safe therapeutic strategy and effective vaccine is critical to overcoming severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Therefore, elucidation