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Publikováno v:
Internal Medicine Journal. 52:1733-1740
Background Peripherally inserted central catheters (PICCs) are commonly used in cancer patients. PICC-associated upper limb venous thromboembolism (PaULVTE, non-deep and deep involving veins proximal to the brachial vein) and distant VTE (i.e. pulmon
Publikováno v:
Current Eye Research. 47:1300-1311
Background: Phase I/II clinical trials using fetal retinal pigment epithelium (fRPE), human embryonic stem cell (hESC)-derived RPE, or human induced pluripotent stem cell (hiPSC)-derived RPE as potential sources of materials for cell-based therapy to
Autor:
Shuang-Jian Qiu, Ruo-Yu Guan, Jian Sun, Cheng Zhou, Jia Fan, Bao-Ye Sun, Gao Liu, Jian Zhou, Zhu-Tao Wang, Pei-Yun Zhou, Zhang-Fu Yang, Yong Yi
Publikováno v:
Digestive and Liver Disease. 54:692-700
Background Brahma-related gene 1 (BRG1) is essential for embryogenesis and cellular metabolism. A deficiency of BRG1 in vivo decreases lipid droplets, but the molecular mechanism underlying its role in lipid metabolism associated with hepatocellular
Autor:
Mary Lynn Savoie, Jan Storek, Megan Kinzel, Mona Shafey, Rehan M. Faridi, Faisal Khan, Rutvij A. Khanolkar, Kareem Jamani
Publikováno v:
Cytotherapy. 24:413-420
Background aims The internal tandem duplication of FLT3 (FLT3ITD) and NPM1 mutations (NPM1mut) are well-established prognostic factors in cytogenetically intermediate-risk acute myeloid leukemia (AML) when treated with chemotherapy alone. However, th
Autor:
Serguei Ilchenko, Clara Kurishima, Felix Woitek, Mitsuru Seki, Lucia Carlucci, Helen Piontkivska, Takhar Kasumov, Fabio A. Recchia, Gia Burjanadze, Nikoloz Gorgodze, Kenneth Walsh, Ayse Keles, Khatia Gabisonia
Publikováno v:
Journal of Cardiac Failure. 28:588-600
Protein pool turnover is a critically important cellular homeostatic component, yet it has been little explored in the context of heart failure (HF) pathophysiology. We employed in vivo 2H labeling/ proteome dynamics for non-biased discovery of turno
Autor:
Won-Ki Kim, Yeonsoo Joe, Jeongmin Park, Young-Joon Surh, Su-Jung Kim, Hun Taeg Chung, Seung Hyeon Kim, Hye-Kyung Na, Ishrat Aklima Muna, Ha-Na Lee, Shin-Young Gwak
Publikováno v:
Gut and Liver. 16:246-258
Background/aims Heme oxygenase-1 (HO-1) plays a central role in cellular defense against inflammatory insults, and its induction in macrophages potentiates their efferocytic activity. In this study, we explored the potential role of macrophage HO-1 i
Autor:
Jishi Wang, Michael Schmitt, William Krüger, Maria-Luisa Schubert, Sanmei Wang, Volker Eckstein, Peter Dreger, Carsten Müller-Tidow, Lei Wang, Thomas Luft, Stefan Schönland, Brigitte Neuber, Angela Hückelhoven-Krauss, Tim Sauer, Ming Ni, Ute Hegenbart, Wenjie Gong, Yuntian Ding, Anita Schmitt
Publikováno v:
Cytotherapy. 24:311-319
Extracorporeal photopheresis (ECP), a personalized cellular immunotherapy, constitutes a promising treatment for steroid-refractory/-resistant graft-versus-host disease (SR-GvHD), with encouraging clinical response rates. To further investigate its m
Autor:
Sudha Ravi, Ruoyu Shi, Nur Diyana Md Nasir, Chee Leong Cheng, Aye Aye Thike, Puay Hoon Tan, Kevin Seng Loong Oh, Johnathan Xiande Lim, Timothy Kwang Yong Tay, Kim Hock Ng, Valerie Cui Yun Koh, Venice Jing Ning Hiew, Kenny Wei Jie Chua, Seow Ye Heng, Joshua Rodrigues, Benjamin Yongcheng Tan, Gary Jian Zhe Ng, Yier Li
Publikováno v:
Laboratory Investigation. 102:245-252
Breast fibroepithelial lesions (FEL) are biphasic tumors which consist of benign fibroadenomas (FAs) and the rarer phyllodes tumors (PTs). FAs and PTs have overlapping features, but have different clinical management, which makes correct core biopsy
Autor:
Lequina Myles, Terry David Church
Publikováno v:
Cytotherapy. 24:344-355
Background aims The novelty of cell and gene therapies (CGTs) has introduced unique supply chain challenges and considerations not seen by chemically synthesized (small-molecule) drugs. These complexities increase during the clinical phases, where dr
Publikováno v:
Cytotherapy. 24:225-234
Background aims Several studies have shown the efficacy of mesenchymal stem cell (MSC) therapy for lower extremity vascular disease (LEVD) in diabetic patients, but the results are not consistent. Therefore, the authors conducted a meta-analysis of r