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Autor:
Liang Chen, Xiaojun Yu, Xiang Gao, Zunliang Ke, Wenqu Jiang, Qiwei Huang, Guobin Zhang, Chao Li
Publikováno v:
Biochemical and Biophysical Research Communications. 586:34-41
Molecular biomarkers play an important guidance role in the diagnosis and treatment of glioma. It has been found that TRAM2 (translocation associated membrane protein 2) drives human cancers development. Here we report that TRAM2 activity is required
Autor:
Li Li, Glenda C. Gobe, David A. Vesey, Christudas Morais, Rajagopalan Prasanna, Evan P. Owens, Hossam Kamli
Publikováno v:
Biochemical and Biophysical Research Communications. 586:42-48
Sunitinib is one of the first-line multi-tyrosine kinase inhibitors for metastatic renal cell carcinoma, and resistance to sunitinib continues to be a limiting factor for the successful treatment. As interleukin-6 (IL-6) is overexpressed in sunitinib
Publikováno v:
Biochemical and Biophysical Research Communications. 584:60-65
Current study is intended to evaluate the expression and epigenetic variations of mitochondrial situins in 306 rheumatoid arthritis (RA) cases and compared with age/gender matched controls.The expression level was measured using the quantitative Real
Autor:
Dhiraj Kumar, Imtaiyaz Hassan
Publikováno v:
Biochemical and Biophysical Research Communications. 585:124-131
Disease models have proven useful tools for gaining deeper mechanistic insights into neurodegenerative diseases. In this context, stem cell technology is effective, especially induced pluripotent stem cell (iPSC)-derived brain organoids and cell repl
Autor:
Johanna Zerbib, Daniel Aberdam, Edward Pichinuk, Elie Frank, Léa Zennaro, Keren Oved, Orly Dorot, Lauriane N. Roux, Dominique Bremond-Gignac
Publikováno v:
Biochemical and Biophysical Research Communications. 582:100-104
Aniridia is a panocular inherited rare eye disease linked to heterozygous mutations on the PAX6 gene, which fail to properly produce sufficient protein essential for normal eye development and function. Most of the patients suffer from aniridia-relat
Publikováno v:
Biochemical and Biophysical Research Communications. 584:73-79
Radiotherapy plays a major role in non-small cell lung cancer (NSCLC) treatment. The curative efficacy of advanced NSCLC is unsatisfactory because of its radioresistance to conventional radiotherapy. The biomarkers which can be used to diagnose radio
Publikováno v:
Biochemical and Biophysical Research Communications. 577:158-164
Sorafenib is a tyrosine kinase inhibitor that shows anti-tumour effects against various cancers including gastric cancer (GC). However, the clinical application of sorafenib is often hampered by drug resistance. Sirtuins 6 (SIRT6) is a member of the
Publikováno v:
Biochemical and Biophysical Research Communications. 577:6-11
Premature ovarian failure (POF) is defined by amenorrhea, hypoestrogenism, elevated gonadotropin levels, and infertility. Chemotherapeutic agents are the most gonadotoxic agents that lead to POF. Although some previous studies have presented that mes
Autor:
Jinqi Wang, Haozhen Lv, Xuanhao Zeng, Yating Liu, Qi Zhang, Jinhua Xu, Weiling Lian, Kelu Wei
Publikováno v:
Biochemical and Biophysical Research Communications. 573:151-157
Although surgical interventions have become optional for refractory vitiligo, grafting related injuries is inevitable. Embryonic stem cell (ESC) derivatives can be used in transplantation to address this issue, but the immune rejection due to allogen
Publikováno v:
Biochemical and Biophysical Research Communications. 576:73-79
Objectives MicroRNA-199b-3p (miR-199b-3p) plays a crucial role in the malignant development of various cancers, but little known in prostate cancer (PCa). The aim of our study was to demonstrate the function of miR-199b-3p in PCa. Methods Quantitativ