Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sergio Valente"'
Autor:
Andrea Mattevi, Marcello Tortorici, Paolo Trifiro, Giuseppe Meroni, Mario Varasi, Paola Dessanti, Oronza A. Botrugno, Florian Thaler, Manuela Villa, Giuseppe Ciossani, Sergio Valente, Paola Vianello, Anna Cappa, Antonello Mai, Ciro Mercurio, Saverio Minucci
Publikováno v:
European Journal of Medicinal Chemistry. 86:352-363
Histone demethylase KDM1A (also known as LSD1) has become an attractive therapeutic target for the treatment of cancer as well as other disorders such as viral infections. We report on the synthesis of compounds derived from the expansion of tranylcy
Autor:
Francesco Spallotta, Carlo Gaetano, Antonello Mai, Andreas M. Zeiher, Fabio Martelli, Sergio Valente, Chiara Cencioni
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 14, Iss 9, Pp 17643-17663 (2013)
International Journal of Molecular Sciences; Vol 14
International Journal of Molecular Sciences, Vol 14, Iss 9, Pp 17643-17663 (2013)
International Journal of Molecular Sciences; Vol 14
Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are availab
Autor:
Fabio Manzo, Sergio Valente, Angela Nebbioso, Antonello Mai, Lucia Altucci, Annamaria Scognamiglio
Publikováno v:
Biochimica et Biophysica Acta-Molecular Cell Research
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2008, 1783 (10), pp.2030-8. ⟨10.1016/j.bbamcr.2008.07.007⟩
Biochimica et Biophysica Acta-Molecular Cell Research, 2008, 1783 (10), pp.2030-8. ⟨10.1016/j.bbamcr.2008.07.007⟩
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2008, 1783 (10), pp.2030-8. ⟨10.1016/j.bbamcr.2008.07.007⟩
Biochimica et Biophysica Acta-Molecular Cell Research, 2008, 1783 (10), pp.2030-8. ⟨10.1016/j.bbamcr.2008.07.007⟩
International audience; Discovered for their ability to deacetylate histones and repress transcription, HDACs are a promising target for therapy of human diseases. The class II HDACs are mainly involved in developmental and differentiation processes,
Autor:
Ilaria Cerbara, Dante Rotili, Antonello Mai, Silvio Massa, Riccardo Pezzi, Rino Ragno, Silvia Simeoni, Sergio Valente
Publikováno v:
Medicinal Research Reviews. 25:261-309
The reversible histone acetylation and deacetylation are epigenetic phenomena that play critical roles in the modulation of chromatin topology and the regulation of gene expression. Aberrant transcription due to altered expression or mutation of gene
Autor:
François Gaascht, Gilbert Kirsch, Clemens Zwergel, Antonello Mai, Sergio Valente, Marc Diederich, Michael Schnekenburger, Mario Dicato, Carole Seidel
Publikováno v:
Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2014, 24 (16), pp.3797-3801. ⟨10.1016/j.bmcl.2014.06.067⟩
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2014, 24 (16), pp.3797-3801. ⟨10.1016/j.bmcl.2014.06.067⟩
International audience; Histone deacetylases (HDACs) are well-established, promising targets for anticancer therapy due to their critical role in cancer development. Accordingly, an increasing number of HDAC inhibitors displaying cytotoxic effects ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04d1b4ec01fbb9ec38413de909f89f8
https://hal.univ-lorraine.fr/hal-01494600
https://hal.univ-lorraine.fr/hal-01494600
Autor:
Silvio Massa, Antonello Mai, Fabio Manzo, Lucia Altucci, Silvia Simeoni, Rino Ragno, Angela Nebbioso, Floriana De Bellis, Gerald Brosch, Sergio Valente
Publikováno v:
The international journal of biochemistrycell biology. 41(1)
Aroyl-pyrrolyl-hydroxy-amides (APHAs) are a class of synthetic HDAC inhibitors described by us since 2001. Through structure-based drug design, two isomers of the APHA lead compound 1, the 3-(2-benzoyl-1-methyl-1H-pyrrol-4-yl)-N-hydroxy-2-propenamide
Autor:
Saverio Minucci, Anna Cappa, Antonello Mai, Andrea Mattevi, Mario Varasi, Paola Dessanti, Manuela Villa, Sergio Valente, Oronza A. Botrugno, R. Dal Zuffo, Florian Thaler, Ciro Mercurio, Paolo Trifiro, Paola Vianello, Giuseppe Meroni
Publikováno v:
European Journal of Cancer. 50:185
KDM1A, a FAD dependent histone demethylase with high homology to amino-oxidases, is responsible of the demethylation of mono and dimethyl lysine 4 on histone H3. KDM1A is part of various transcriptional corepressor complexes and interacts with the co