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of 3
pro vyhledávání: '"Martín, Hugo"'
Autor:
Martín Hugo, Ioanna Korovila, Markus Köhler, Carlos García-García, J. Daniel Cabrera-García, Anabel Marina, Antonio Martínez-Ruiz, Tilman Grune
Publikováno v:
Redox Biology, Vol 16, Iss , Pp 123-128 (2018)
Under oxidative stress 26S proteasomes suffer reversible disassembly into its 20S and 19S subunits, a process mediated by HSP70. This inhibits the degradation of polyubiquitinated proteins by the 26S proteasome and allows the degradation of oxidized
Externí odkaz:
https://doaj.org/article/7d9b921d4d51413b8a5f2dd006f3c94f
Autor:
Ioanna Korovila, Martín Hugo, José Pedro Castro, Daniela Weber, Annika Höhn, Tilman Grune, Tobias Jung
Publikováno v:
Redox Biology, Vol 13, Iss C, Pp 550-567 (2017)
The production of reactive species is an inevitable by-product of metabolism and thus, life itself. Since reactive species are able to damage cellular structures, especially proteins, as the most abundant macromolecule of mammalian cells, systems are
Externí odkaz:
https://doaj.org/article/75e4d02c5203422fbbe8cbcc7ce3f931
Autor:
Jeannette König, Christiane Ott, Martín Hugo, Tobias Jung, Anne-Laure Bulteau, Tilman Grune, Annika Höhn
Publikováno v:
Redox Biology, Vol 11, Iss , Pp 673-681 (2017)
Mitochondria have been in the focus of oxidative stress and aging research for decades due to their permanent production of ROS during the oxidative phosphorylation. The hypothesis exists that mitochondria are involved in the formation of lipofuscin,
Externí odkaz:
https://doaj.org/article/fed2184c83f44ab782e17121d1532729