Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Brendan J. Keating"'
Publikováno v:
Genet Epidemiol
Genetic matching between transplant donor and recipient pairs has traditionally focused on the human leukocyte antigen (HLA) regions of the genome, but recent studies suggest that matching for non-HLA regions may be important as well. We assess four
Autor:
Alexander P. Maxwell, Peter J. Conlon, Jessica van Setten, Brendan J. Keating, Claire Kennedy, Jamie P. Traynor, Paul J. Phelan, M. Lee Sanders, Fiona A. Chapman, Caragh P. Stapleton, Kelly A. Birdwell, Amy Jayne McKnight, Patrick B. Mark, Alan G. Jardine, Gianpiero L. Cavalleri
Publikováno v:
American Journal of Transplantation, 19(3), 801. Blackwell Publishing Asia Pty Ltd
Stapleton, C P, Birdwell, K A, McKnight, A J, Maxwell, A P, Mark, P B, Sanders, M L, Chapman, F A, van Setten, J, Phelan, P J, Kennedy, C, Jardine, A, Traynor, J P, Keating, B, Conlon, P J & Cavalleri, G L 2019, ' Polygenic risk score as a determinant of risk of non-melanoma skin cancer in a European-descent renal transplant cohort ', American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol. 19, no. 3, pp. 801-810 . https://doi.org/10.1111/ajt.15057
Stapleton, C P, Birdwell, K A, McKnight, A J, Maxwell, A P, Mark, P B, Sanders, M L, Chapman, F A, van Setten, J, Phelan, P J, Kennedy, C, Jardine, A, Traynor, J P, Keating, B, Conlon, P J & Cavalleri, G L 2019, ' Polygenic risk score as a determinant of risk of non-melanoma skin cancer in a European-descent renal transplant cohort ', American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol. 19, no. 3, pp. 801-810 . https://doi.org/10.1111/ajt.15057
Renal transplant recipients have an increased risk of non-melanoma skin cancer (NMSC) compared to in the general population. Here, we show polygenic risk scores (PRS) calculated from genome-wide association studies (GWAS) of NMSC in general, non-tran
Autor:
Mark Seielstad, Adam S. Butterworth, Stacy M Endres-Dighe, Connie M. Westhoff, Aarash Bordbar, Yontao Lu, Steve Kleinman, Brian Custer, Brendan J. Keating, Carolyn Hoppe, Tamir Kanias, Yuelong Guo, Michael P. Busch, Alan E. Mast, Grier P. Page
Publikováno v:
Transfusion. 59:101-111
Background Many aspects of transfusion medicine are affected by genetics. Current single-nucleotide polymorphism (SNP) arrays are limited in the number of targets that can be interrogated and cannot detect all variation of interest. We designed a tra
Autor:
Caragh P. Stapleton, Andreas Heinzel, Weihua Guan, Peter J. van der Most, Jessica van Setten, Graham M. Lord, Brendan J. Keating, Ajay K. Israni, Martin H. de Borst, Stephan J.L. Bakker, Harold Snieder, Michael E. Weale, Florence Delaney, Maria P. Hernandez-Fuentes, Roman Reindl-Schwaighofer, Rainer Oberbauer, Pamala A. Jacobson, Patrick B. Mark, Fiona A. Chapman, Paul J. Phelan, Claire Kennedy, Donal Sexton, Susan Murray, Alan Jardine, Jamie P. Traynor, Amy Jayne McKnight, Alexander P. Maxwell, Laura J. Smyth, William S. Oetting, Arthur J. Matas, Roslyn B. Mannon, David P. Schladt, David N. Iklé, Gianpiero L. Cavalleri, Peter J. Conlon
Publikováno v:
Am J Transplant
American Journal of Transplantation, 19(8), 2262-2273. Wiley
American Journal of Transplantation, 19(8), 2262-2273. Wiley
Genetic variation across the human leukocyte antigen loci is known to influence renal-transplant outcome. However, the impact of genetic variation beyond the human leukocyte antigen loci is less clear. We tested the association of common genetic vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f0fdd84d7f673295f53f196b51d5e6
https://europepmc.org/articles/PMC6989089/
https://europepmc.org/articles/PMC6989089/
Publikováno v:
Transplant international : official journal of the European Society for Organ Transplantation. 31(3)
While advances in patient care and immunosuppressive pharmacotherapies have increased the lifespan of heart allograft recipients, there are still significant comorbidities post-transplantation and 5-year survival rates are still significant, at appro
Autor:
Mary E. Fischer, Barbara E.K. Klein, Ted S. Tweed, Karen J. Cruickshanks, Carla R. Schubert, Ronald Klein, Dayna S. Dalton, Guan-Hua Huang, David M. Nondahl, Brendan J. Keating
Publikováno v:
Atherosclerosis. 238:344-349
The study's purpose was to test if subclinical atherosclerosis was associated with the risk of developing HI in a large cohort of middle-aged participants.Study subjects were members of the Beaver Dam Offspring Study (BOSS), a longitudinal study of a
Autor:
Sarah C. Stallings, Eric B. Larson, Stuart A. Scott, John Connolly, Teri A. Manolio, Murray H. Brilliant, Ingrid A. Holm, Marylyn D. Ritchie, David Carrell, Dan M. Roden, Berta Almoguera, Laura J. Rasmussen-Torvik, Joshua C. Denny, Ana R. Mejia, Carlos J. Gallego, Wendy A. Wolf, James D. Ralston, Ariel Brautbar, Cassandra Perry, John B. Harley, Brendan J. Keating, Catherine A. McCarty, Rongling Li, Jonathan L. Haines, Josh F. Peterson, Jennifer A. Pacheco, Cynthia A. Prows, Kimberly F. Doheny, Erwin P. Bottinger, Rex L. Chisholm, Christopher G. Chute, Iftikhar J. Kullo, Jyotishman Pathak, Suzette J. Bielinski, Aida Vega, Melissa A. Basford, Luke V. Rasmussen, Shannon Manzi, Daniel Seung Kim, Omri Gottesman, Deborah A. Nickerson, David R. Crosslin, Steven E. Scherer, Adam S. Gordon, Senthilkumar Sadhasivam, Kathleen A. Leppig, Marc S. Williams, Simona Volpi, Maureen E. Smith, Simon Lin, Gail P. Jarvik, Vivian Pan, Alexander A. Vinks
Publikováno v:
Clinical pharmacology and therapeutics
We describe here the design and initial implementation of the eMERGE-PGx project. eMERGE-PGx, a partnership of the Electronic Medical Records and Genomics Network and the Pharmacogenomics Research Network, has three objectives: (i) to deploy PGRNseq,
Autor:
Mary Cushman, Shad B. Smith, Patricia A. Peyser, Jorge L. Rodriguez-Gil, Struan F.A. Grant, Regina G. Ziegler, Timothy D. Howard, Imran O. Morhason-Bello, Mariaelisa Graff, Christopher S. Carlson, Cameron D. Palmer, Charleston W. K. Chiang, Evandine Rampersaud, Lisa Chu, Uma Nayak, Curtis A. Pettaway, Ye Feng, Jing Hua Zhao, Barbara V. Howard, Joanne M. Jordan, Gregory L. Burke, Melinda C. Aldrich, Dezheng Huo, Omri Gottesman, Richard S. Cooper, Sonja I. Berndt, Donna K. Arnett, Gary S. Gilkeson, M. Cristina Leske, Ulrich Broeckel, Edmond K. Kabagambe, Stephen J. Chanock, Michael J. Thun, John S. Witte, William Maixner, Adebowale Adeyemo, Oladosu Ojengbede, Sarah J. Nyante, William J. Blot, Nicholette D. Palmer, Jyotika K. Fernandes, Laura J. Rasmussen-Torvik, Julie R. Palmer, Ida J. Spruill, Wei Zheng, Ruth J. F. Loos, Guo Li, Robert C. Millikan, Donald W. Bowden, Ellen W. Demerath, Michèle M. Sale, Neil A. Zakai, Zhaoming Wang, Fang Chen, George J. Papanicolaou, Gary K. Chen, Talin Haritunians, Rajiv Nadukuru, James J. Yang, Brian E. Henderson, Sandra Deming-Halverson, Adesola Ogunniyi, David Van Den Berg, Diane L. Kamen, Phyllis J. Goodman, Eric A. Klein, Yingchang Lu, Thomas W. Winkler, Marguerite R. Irvin, Badri Padhukasahasram, Benjamin A. Rybicki, Yan V. Sun, Yii-Der Ida Chen, Temidayo O. Ogundiran, Andrew B. Singleton, Babatunde L. Salako, Vaneet Lotay, Christine B. Ambrosone, Karen C. Johnson, Michael F. Press, Neil E. Caporaso, Guillaume Lettre, Ingrid B. Borecki, Sue A. Ingles, Yonglan Zheng, Jennifer J. Hu, Leslie Bernstein, Keri L. Monda, Kristine R. Monroe, L. Keoki Williams, Thomas H. Mosley, Shamika Ketkar, Ryan W. Driver, Margaret A. Tucker, Josyf C. Mychaleckyj, Ann W. Hsing, Xiuqing Guo, Lewis H. Kuller, Patricia M. Dubbert, Kelly J. Hunt, JoAnn E. Manson, Joel N. Hirschhorn, Mara Z. Vitolins, Tamara B. Harris, Matthew A. Allison, Abdullah Kutlar, Leslie A. Lange, Yongmei Liu, Ulrike Peters, Hakon Hakonarson, Mary K. Wojczynski, Xiaofeng Zhu, Edward A. Ruiz-Narváez, Todd L. Edwards, Heather M. Ochs-Balcom, Jingzhong Ding, Albert M. Levin, W. Timothy Garvey, Digna R. Velez Edwards, Sun J. Kang, Jie Zhou, Barry I. Freedman, Sanjay R. Patel, Suh Yuh Wu, Sylvia Wassertheil-Smoller, Simin Liu, Daniel Shriner, Elizabeth K. Speliotes, Larry D. Atwood, Graham Casey, Lisa R. Yanek, Susan Redline, Lisa B. Signorello, Wei Zhao, Scott M. Williams, Bamidele O. Tayo, Kira C. Taylor, Angela Britton, Xifeng Wu, Erwin P. Bottinger, Charles N. Rotimi, Mary F. Feitosa, Joseph M. Zmuda, Curtis C. Harris, Christine Neslund-Dudas, Bruce M. Psaty, Alexander P. Reiner, Helen N. Lyon, Youfang Liu, Krista A. Zanetti, Jonathan P. Bradfield, Esther M. John, Ann G. Schwartz, Elizabeth M. Gillanders, Mike A. Nalls, Suzanne Kolb, Cathryn H. Bock, Alan B. Zonderman, David Duggan, Gerhard A. Coetzee, Charles Kooperberg, Sharon L.R. Kardia, Olufunmilayo I. Olopade, Suhn K. Rhie, John D. Carpten, Maggie C.Y. Ng, Kari E. North, Christopher A. Haiman, Barbara Nemesure, Loic Le Marchand, Christopher I. Amos, Adeyinka Ademola, Lara Sucheston, Pamela J. Schreiner, Taylor Young, Sara S. Strom, Carl D. Langefeld, Jason H. Moore, Marian L. Neuhouser, Lawrence F. Bielak, Diane M. Becker, Margaret Wrensch, Janet L. Stanford, Laurence N. Kolonel, Yan A. Meng, Margaret R. Spitz, Brendan J. Keating, Kurt Lohman, Virginia J. Howard, Guanjie Chen, Elisa V. Bandera, Quiyin Cai, Amidou N'Diaye, Stefan Ambs, Adam B. Murphy, Eric E. Schadt, Anselm Hennis, Rick A. Kittles, Caroline S. Fox, John K. Wiencke, Katherine L. Nathanson, Barbara McKnight, Michele K. Evans, Wei-Min Chen, Dena G. Hernandez, Herman A. Taylor, David S. Siscovick, Lorna H. McNeill
Publikováno v:
Nature genetics
Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of3.2 million SNPs with BMI in 39,144 men
Autor:
F. Javier Nieto, Ronald Klein, Karen J. Cruickshanks, Barbara E.K. Klein, Brendan J. Keating, Mary E. Fischer, James S. Pankow, Derek J. Snyder, Alex Pinto, Carla R. Schubert
Publikováno v:
Chemosensory Perception. 5:139-145
BACKGROUND: Standard clinical advice for the prevention and treatment of hypertension includes limitation of salt intake. Previous studies of the association between perception of salt taste and hypertension prevalence have not reported consistent re
Autor:
Rory P. Remmel, Brendan J. Keating, Pamala A. Jacobson, Casey R. Dorr, Roslyn B. Mannon, B. Herrera, Arthur J. Matas, Pui-Yan Kwok, W. Guan, David P. Schladt, Ajay K. Israni, William S. Oetting, Michael B. Miller, Kinjal Sanghavi, Daniel R. Salomon
Publikováno v:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol 16, iss 2
We previously reported that tacrolimus (TAC) trough blood concentrations for African American (AA) kidney allograft recipients were lower than those observed in white patients. Subtherapeutic TAC troughs may be associated with acute rejection (AR) an