Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Hideo Araki"'
Autor:
Yukiko Yamamoto, Kazuyo Kakoi, Yoshinori Satomi, Hiroyuki Sumi, Satoru Nishizawa, Kazunobu Aoyama, Megumi Hirayama, Ikuo Miyahisa, Hironobu Maezaki, Kohei Honda, Hideo Araki, Takahito Hara, Ryuuichi Nishigaki, Masako Sasaki, Satoshi Kitazawa, Imamura Keisuke, Yoshihiko Satoh
Publikováno v:
European Journal of Pharmacology. 807:21-31
Most cancer cells are characterized by elevated lipid biosynthesis. The rapid proliferation of cancer cells requires de novo synthesis of fatty acids. Stearoyl-CoA desaturase-1 (SCD1), a key enzyme for lipogenesis, is overexpressed in various types o
Publikováno v:
Journal of Physiology-Paris. 95:157-163
Gastrointestinal ulcerogenic effect of indomethacin is causally related with an endogenous prostaglandin (PG) deficiency, yet the detailed mechanism remains unknown. We examined the effect of various PGE analogues specific to EP receptor subtypes on
Autor:
Shoji Kawauchi, Hiroyuki Mizoguchi, Tomonori Kunikata, Koji Takeuchi, Hideo Araki, Kimihito Tashima
Publikováno v:
Journal of Gastroenterology and Hepatology. 15:37-45
The present article overviews the regulatory mechanism of acid secretion in the stomach after damage with taurocholate (TC), one of the bile acids. Mucosal exposure of a rat stomach to 20 mmol/L TC for 30 min caused a decrease of acid secretion with
Autor:
Hidekazu Nishiwaki, Osamu Furukawa, Hideo Araki, Masakazu Umeda, Koji Takeuchi, Akinobu Fujita
Publikováno v:
Life Sciences. 65:1207-1216
Gastric mucosal blood flow (GMBF) response and the recovery of gastric mucosal integrity were investigated in anesthetized rat stomachs after damage by monochloramine (NH2Cl), in comparison with 20 mM taurocholate Na (TC). A rat stomach was mounted i
Publikováno v:
Journal of physiology, Paris. 95(1-6)
We examined the gastric ulcerogenic property of selective COX-1 and/or COX-2 inhibitors in rats, and investigated whether COX-1 inhibition is by itself sufficient for induction of gastric damage. Animals fasted for 18 h were given various COX inhibit
Autor:
Masakazu Umdeda, Keizo Suzuki, Hiroyuki Mizoguchi, Hideo Araki, Koji Takeuchi, Shinichi Sugamoto
Publikováno v:
Journal of physiology, Paris. 93(5)
We examined the roles of endogenous prostaglandins (PGs) and nitric oxide (NO) in the gastroduodenal ulcerogenic responses to hypothermic stress (28∼30 °C) in anesthetized rats. Lowering body temperature provoked damage in the gastroduodenal mucos
Publikováno v:
Alimentary pharmacologytherapeutics. 13(6)
To examine gastric mucosal ulcerogenic responses to indomethacin and HCl/ethanol in adjuvant arthritic (AA) rats.Arthritis was induced in male Dark Agouti (DA) rats by injection of Freund's complete adjuvant (FCA) into the right hind paw. The gastric