Zobrazeno 1 - 10
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pro vyhledávání: ''
Autor:
Richard Aarnio, Semi Helin, Lauri Nummenmaa, Marco Bucci, Annie von Eyken, Tatu Kantonen, Tomi Karjalainen, Kari K. Kalliokoski, Noora Houttu, Tapani Rönnemaa, Laura Pekkarinen, Kirsi Laitinen, Alex M. Dickens, Anna K. Kirjavainen, Jussi Hirvonen, Pirjo Nuutila, Merja Haaparanta-Solin
Publikováno v:
International Journal of Obesity (2005)
Background Obesity is a pressing public health concern worldwide. Novel pharmacological means are urgently needed to combat the increase of obesity and accompanying type 2 diabetes (T2D). Although fully established obesity is associated with neuromol
Publikováno v:
Experimental & Molecular Medicine
Intermittent fasting (IF) is gaining popularity for its effectiveness in improving overall health, including its effectiveness in achieving weight loss and euglycemia. The molecular mechanisms of IF, however, are not well understood. This study inves
Autor:
Masaoki Ito, Andrés F. Cardona, Andrés Aguilar, Jordi Codony-Servat, Mariacarmela Santarpia, Rafael Rosell, Carlos González Pedraz, Oscar Arrieta
Publikováno v:
British Journal of Cancer
Epidermal growth factor receptor (EGFR) mutations in lung adenocarcinoma are a frequent class of driver mutations. Single EGFR tyrosine kinase inhibitor (TKI) provides substantial clinical benefit, but almost nil radiographic complete responses. Pati
Autor:
Irina Ostrovnaya, David B. Solit, Timothy R. Donahue, Eugene K. Cha, Ashley Marie Regazzi, Samuel Funt, Eugene J. Pietzak, Hikmat Al-Ahmadie, Gopakumar Iyer, Min Yuen Teo, Guido Dalbagni, Jonathan E. Rosenberg, Satish K. Tickoo, Victor E. Reuter, Kenneth Seier, Christopher Michael Tully, Bernard H. Bochner, Sherri M. Donat, Harry W. Herr, Dean F. Bajorin
Publikováno v:
British Journal of Cancer
Background Plasmacytoid urothelial carcinoma (PUC) is a rare, aggressive histologic variant of urothelial cancer characterised by a diffuse growth pattern and CDH1 mutation. We studied the efficacy of preoperative platinum-based chemotherapy in nonme
Autor:
Ying Jing, Yi Zhang, Minhua Yu, Mei-Chun Cai, Lin Cheng, Wenjing Wang, Xia Yin, Huaiwu Lu, Lihua Qiu, Caiyan Zhang, Haijiao Lu, Wen Di, Li Tan, Jie Wu, Jiejun Cheng, Guanglei Zhuang, Weihua Lou
Publikováno v:
British Journal of Cancer
Background We aimed to comprehensively evaluate the immunologic landscape at baseline and upon chemotherapy in cervical cancer. The information should aid ongoing clinical investigations of checkpoint blockade immunotherapies in this disease setting.
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Exposure to infection in utero predisposes towards psychiatric diseases such as autism, depression and schizophrenia in later life. The mechanisms involved are typically studied by administering mimetics of double-stranded (ds) RNA viral or bacterial
Autor:
Hidetsugu Saito, Satoshi Hashino, Yuko Ishihara, Masashi Mizokami, Kazuaki Inoue, Makoto Onizuka, Masahiro Onozawa, Kazuhiko Kakihana, Masaya Sugiyama, Koji Nishikawa, Ishikazu Mizuno, Yasushi Onishi, Masahide Yamamoto, Shigeru Kusumoto, Hisashi Sakamaki, Noriko Doki, Tetsuya Ishikawa, Kazuteru Ohashi, Kazuhiro Takahashi, Tatsuya Kanto, Yoshinobu Kanda, Sung Kwan Bae, Kiminori Kimura
Publikováno v:
Bone Marrow Transplantation
Hepatitis B virus (HBV) reactivation reportedly occurs frequently after hematopoietic stem cell transplantation (HSCT) in resolved HBV-infected patients. Here, 50 patients with resolved HBV infections and scheduled to undergo HSCT were enrolled; all
Autor:
Kae Okuma, Yuka Asami, Naoya Murakami, Kouya Shiraishi, Mayumi Kobayashi Kato, Jun Itami, Maiko Matsuda, Ryuji Hamamoto, Daisuke Takayanagi, Yoko Shimada, Masaaki Komatsu, Takashi Kohno, Tomoyasu Kato, Ikumi Kuno, Sou Hirose, Hiroshi Yoshida
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Targeted sequencing for somatic mutations across the hotspots of 50 cancer-related genes was performed using biopsy specimens to investigate whether clinicopathological factors and genomic alterations correlated with prognosis in locally advanced cer
Autor:
Nathan Qi, Maria Dolors Sans, Jason I. E. Bruce, Sarah A. Sugden, John A. Williams, Andrew D. James, Rosa Sánchez-Alvarez
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Acute pancreatitis (AP) is serious inflammatory disease of the pancreas. Accumulating evidence links diabetes with severity of AP, suggesting that endogenous insulin may be protective. We investigated this putative protective effect of insulin during
Autor:
Johannes Kluwe, Stefan Blankenberg, Daniel Benten, Gunnar K. Lund, Malte Klein, Ulf K Radunski, Ansgar W. Lohse, Enver Tahir, A Galante, Christoph Sinning, Kai Muellerleile, Peter Bannas, Christian Stehning, Sebastian Bohnen, Gerhard Adam, Jitka Starekova
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Transjugular intrahepatic portosystemic shunt (TIPS) reduces portal hypertension in patients with liver cirrhosis. The exact cardiac consequences of subsequent increase of central blood volume are unknown. Cardiovascular magnetic resonance (CMR) imag