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Autor:
Flavia Millesi, Lorenz Semmler, Dietmar Pils, Christine Radtke, Aida Naghilou, Tamara Weiss, Anda Mann, Maximilian Haertinger, P Supper
Publikováno v:
The FASEB Journal
The search for a suitable material to promote regeneration after long‐distance peripheral nerve defects turned the spotlight on spider silk. Nerve conduits enriched with native spider silk fibers as internal guiding structures previously demonstrat
Autor:
Shunsuke Noda, Masashi Tomimatsu, Sayuri Mitsuoka, Yasushi Fujio, Yoshiaki Miyake, Simon J. Conway, Soshi Kanemoto, Masanori Obana, Takeo Harada, Shota Tanaka, Makiko Maeda, Ayaha Yamamoto, Kotaro Matsumoto, Hitomi Morioki, Kazunori Imaizumi, Takafumi Nakae
Publikováno v:
The FASEB Journal
Prevention of kidney fibrosis is an essential requisite for effective therapy in preventing chronic kidney disease (CKD). Here, we identify Old astrocyte specifically induced substance (OASIS)/cAMP responsive element‐binding protein 3‐like 1 (CRE
Autor:
Chenrui Xu, Hans Hebert, Marta Carroni, Ling Han, Céline Schaeffer, Martina Brunati, Alena Stsiapanava, Shigeki Yasumasu, Marcel Bokhove, Luca Jovine, Sara Zamora-Caballero, Bin Wu, Luca Rampoldi
Publikováno v:
The EMBO Journal
Assembly of extracellular filaments and matrices mediating fundamental biological processes such as morphogenesis, hearing, fertilization, and antibacterial defense is driven by a ubiquitous polymerization module known as zona pellucida (ZP) “domai
Autor:
Anjali P. Kusumbe, Luciana Lippo, Michael L. Dustin, Rossella Labella, Brian D. Marsden, Junyu Chen, Saravana K. Ramasamy, Sin Lih Tan
Publikováno v:
The EMBO Journal
Age‐associated alterations of the hormone‐secreting endocrine system cause organ dysfunction and disease states. However, the cell biology of endocrine tissue ageing remains poorly understood. Here, we perform comparative 3D imaging to understand
Autor:
Xinzhou Zhang, Liping Sun
Publikováno v:
Molecular Genetics & Genomic Medicine
Molecular Genetics & Genomic Medicine, Vol 9, Iss 1, Pp n/a-n/a (2021)
Molecular Genetics & Genomic Medicine, Vol 9, Iss 1, Pp n/a-n/a (2021)
Background Mitral valve prolapse (MVP) is a common cardiovascular disease defined as a late systolic click or mitral valve lobes that move up into the left atrium during ventricular systole, with or without mitral insufficiency. Dachsous catherin‐r
Autor:
Shuyi Mai, Wenjun Xiong, Rory R Sheng, Tuancheng Feng, Fenghua Hu, Junke Zhang, Isabel Iscol Katz, Mohammed Ullah, Haiyuan Yu, Jenn Marie Roscoe
Publikováno v:
EMBO Reports
Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal lobar degeneration (FTLD). Loss of PGRN leads to lysosome dysfunction during aging. TMEM106B, a gene encoding a lysosomal membrane protein, is the main risk factor for FTLD
Autor:
Thea Giacomini, Pietro Strisciuglio, Stefano Palladino, Maja Di Rocco, Giuseppe Lassandro, Alberto Gaeta, Valentina Palladino, Mariasavina Severino, Vito Favia, Rita Fischetto, Lucia Zampini, Amelia Morrone, Maria Margherita Mancardi, Alfonso Romano, Maria E. Tripaldi, Paola Giordano
Publikováno v:
Molecular Genetics & Genomic Medicine
Molecular Genetics & Genomic Medicine, Vol 8, Iss 10, Pp n/a-n/a (2020)
Molecular Genetics & Genomic Medicine, Vol 8, Iss 10, Pp n/a-n/a (2020)
Background In GM1 gangliosidosis the lack of function of β‐galactosidase results in an accumulation of GM1 ganglioside and related glycoconjugates in visceral organs, and particularly in the central nervous system, leading to severe disability and
Autor:
Nieves Martin-Alguacil
Publikováno v:
Molecular Genetics & Genomic Medicine
Molecular Genetics & Genomic Medicine, Vol 8, Iss 10, Pp n/a-n/a (2020)
Molecular Genetics & Genomic Medicine, Vol 8, Iss 10, Pp n/a-n/a (2020)
Background Precise diagnosis and classification of CBWA cases can be challenging. BSA are considered when there is a body wall anomaly, skeletal abnormalities, and the umbilical cord is anomalous, absent or rudimentary, and LBWC when there is a body
Autor:
Veit Hornung, Yiming Cheng, Andreas Linder, Stefan Bauernfried, Christophe Jung, Oliver T. Keppler, Manuel Albanese
Publikováno v:
The EMBO Journal
Inflammasomes execute a unique type of cell death known as pyroptosis. Mostly characterized in myeloid cells, caspase‐1 activation downstream of an inflammasome sensor results in the cleavage and activation of gasdermin D (GSDMD), which then forms
Publikováno v:
Molecular Genetics & Genomic Medicine
Molecular Genetics & Genomic Medicine, Vol 8, Iss 10, Pp n/a-n/a (2020)
Molecular Genetics & Genomic Medicine, Vol 8, Iss 10, Pp n/a-n/a (2020)
Background The aim of this study was to evaluate the application of BACs‐on‐Beads (BoBs™) assay for rapid detection of chromosomal abnormalities for prenatal diagnosis (PND). Methods A total of 1520 samples, including seven chorionic villi biop