Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Brendan J. Keating"'
Autor:
Amein K. Al-Ali, Abdullah M. Al-Rubaish, Rudaynah A. Alali, Mohammed S. Almansori, Mohammed A. Al-Jumaan, Abdullah M. Alshehri, Mohammed S. Al-Madan, ChittiBabu Vatte, Tess Cherlin, Sylvia Young, Shefali S. Verma, Grant Morahan, Bobby P. C. Koeleman, Brendan J. Keating
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Genome-wide association studies (GWAS) have yielded significant insights into the genetic architecture of myocardial infarction (MI), although studies in non-European populations are still lacking. Saudi Arabian cohorts offer an opportunity
Externí odkaz:
https://doaj.org/article/a5584b01e5674739a800aa16808ae361
Autor:
Yousef M. Alyousef, Stanley Piotrowski, Faisal A. Alonaizan, Ahmed Alsulaiman, Ali A. Alali, Naif N. Almasood, Chittibabu Vatte, Lauren Hamilton, Divya Gandla, Hetal Lad, Fred L. Robinson, Cyril Cyrus, Ryan C. Meng, Alexa Dowdell, Brian Piening, Brendan J. Keating, Amein K. Al-Ali
Publikováno v:
BMC Oral Health, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background Oral microbiome sequencing has revealed key links between microbiome dysfunction and dental caries. However, these efforts have largely focused on Western populations, with few studies on the Middle Eastern communities. The curren
Externí odkaz:
https://doaj.org/article/c89d68a91dc943ffb596c8d8f2b73044
Autor:
Raed M. Alsulaiman, Abdulaziz A. Al-Quorain, Fahad A. Al-Muhanna, Stanley Piotrowski, Ezzeddin A. Kurdi, Chittibabu Vatte, Ahmed A. Alquorain, Noorah H. Alfaraj, Abdulaziz M. Alrezuk, Fred Robinson, Alexa K. Dowdell, Turki A. Alamri, Lauren Hamilton, Hetal Lad, Hui Gao, Divya Gandla, Brendan J. Keating, Ryan Meng, Brian Piening, Amein K. Al-Ali
Publikováno v:
BMC Gastroenterology, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Background Crohn’s diseases and ulcerative colitis, both of which are chronic immune-mediated disorders of the gastrointestinal tract are major contributors to the overarching Inflammatory bowel diseases. It has become increasingly evident
Externí odkaz:
https://doaj.org/article/32fc2a65bec745edb3b8c9007db92ce6
Autor:
Abdulrahman Alasiri, Konrad J. Karczewski, Brian Cole, Bao-Li Loza, Jason H. Moore, Sander W. van der Laan, Folkert W. Asselbergs, Brendan J. Keating, Jessica van Setten
Publikováno v:
BioData Mining, Vol 16, Iss 1, Pp 1-10 (2023)
Abstract Background Loss-of-Function (LoF) variants in human genes are important due to their impact on clinical phenotypes and frequent occurrence in the genomes of healthy individuals. The association of LoF variants with complex diseases and trait
Externí odkaz:
https://doaj.org/article/f8e71408467d4ef6916d54391004dd44
Autor:
Abdulrahman H. Al Anazi, Ahmed S. Ammar, Mahmoud Al-Hajj, Cyril Cyrus, Danah Aljaafari, Iname Khoda, Ahmed K. Abdelfatah, Abdullah A. Alsulaiman, Firas Alanazi, Rawan Alanazi, Divya Gandla, Hetal Lad, Samar Barayan, Brendan J. Keating, Amein K. Al-Ali
Publikováno v:
Human Genomics, Vol 16, Iss 1, Pp 1-9 (2022)
Abstract Background Epilepsy, a serious chronic neurological condition effecting up to 100 million people globally, has clear genetic underpinnings including common and rare variants. In Saudi Arabia, the prevalence of epilepsy is high and caused mai
Externí odkaz:
https://doaj.org/article/54ea118cb75b460a8e7fc6cc9711aa45
Autor:
Fahad A. Al-Muhanna, Alexa K. Dowdell, Abdulmohsen H. Al Eleq, Waleed I. Albaker, Andrew W. Brooks, Ali I. Al-Sultan, Abdullah M. Al-Rubaish, Khaled R. Alkharsah, Raed M. Sulaiman, Abdulaziz A. Al-Quorain, Cyril Cyrus, Rudaynah A. Alali, Chittibabu Vatte, Fred L. Robinson, Xin Zhou, Michael P. Snyder, Afnan F. Almuhanna, Brendan J. Keating, Brian D. Piening, Amein K. Al-Ali
Publikováno v:
BMC Microbiology, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background Large-scale gut microbiome sequencing has revealed key links between microbiome dysfunction and metabolic diseases such as type 2 diabetes (T2D). To date, these efforts have largely focused on Western populations, with few studies
Externí odkaz:
https://doaj.org/article/c8190e3aa79d4cf3b11d0c5dd6c1129f
Autor:
Mahdi S. Abumadini, Kholoud S. Al Ghamdi, Abdullah H. Alqahtani, Dana K. Almedallah, Lauren Callans, Jumanah A. Jarad, Cyril Cyrus, Bobby P. C. Koeleman, Brendan J. Keating, Nathan Pankratz, Amein K. Al-Ali
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionGenome-wide association studies have discovered common polymorphisms in regions associated with schizophrenia. No genome-wide analyses have been performed in Saudi schizophrenia subjects.MethodsGenome-wide genotyping data from 136 Saudi s
Externí odkaz:
https://doaj.org/article/993aea02860b4565801c971e4573415b
Autor:
Amand F. Schmidt, Michael V. Holmes, David Preiss, Daniel I. Swerdlow, Spiros Denaxas, Ghazaleh Fatemifar, Rupert Faraway, Chris Finan, Dennis Valentine, Zammy Fairhurst-Hunter, Fernando Pires Hartwig, Bernardo Lessa Horta, Elina Hypponen, Christine Power, Max Moldovan, Erik van Iperen, Kees Hovingh, Ilja Demuth, Kristina Norman, Elisabeth Steinhagen-Thiessen, Juri Demuth, Lars Bertram, Christina M. Lill, Stefan Coassin, Johann Willeit, Stefan Kiechl, Karin Willeit, Dan Mason, John Wright, Richard Morris, Goya Wanamethee, Peter Whincup, Yoav Ben-Shlomo, Stela McLachlan, Jackie F. Price, Mika Kivimaki, Catherine Welch, Adelaida Sanchez-Galvez, Pedro Marques-Vidal, Andrew Nicolaides, Andrie G. Panayiotou, N. Charlotte Onland-Moret, Yvonne T. van der Schouw, Giuseppe Matullo, Giovanni Fiorito, Simonetta Guarrera, Carlotta Sacerdote, Nicholas J. Wareham, Claudia Langenberg, Robert A. Scott, Jian’an Luan, Martin Bobak, Sofia Malyutina, Andrzej Pająk, Ruzena Kubinova, Abdonas Tamosiunas, Hynek Pikhart, Niels Grarup, Oluf Pedersen, Torben Hansen, Allan Linneberg, Tine Jess, Jackie Cooper, Steve E. Humphries, Murray Brilliant, Terrie Kitchner, Hakon Hakonarson, David S. Carrell, Catherine A. McCarty, Kirchner H. Lester, Eric B. Larson, David R. Crosslin, Mariza de Andrade, Dan M. Roden, Joshua C. Denny, Cara Carty, Stephen Hancock, John Attia, Elizabeth Holliday, Rodney Scott, Peter Schofield, Martin O’Donnell, Salim Yusuf, Michael Chong, Guillaume Pare, Pim van der Harst, M. Abdullah Said, Ruben N. Eppinga, Niek Verweij, Harold Snieder, Lifelines Cohort authors, Tim Christen, D. O. Mook-Kanamori, the ICBP Consortium, Stefan Gustafsson, Lars Lind, Erik Ingelsson, Raha Pazoki, Oscar Franco, Albert Hofman, Andre Uitterlinden, Abbas Dehghan, Alexander Teumer, Sebastian Baumeister, Marcus Dörr, Markus M. Lerch, Uwe Völker, Henry Völzke, Joey Ward, Jill P. Pell, Tom Meade, Ingrid E. Christophersen, Anke H. Maitland-van der Zee, Ekaterina V. Baranova, Robin Young, Ian Ford, Archie Campbell, Sandosh Padmanabhan, Michiel L. Bots, Diederick E. Grobbee, Philippe Froguel, Dorothée Thuillier, Ronan Roussel, Amélie Bonnefond, Bertrand Cariou, Melissa Smart, Yanchun Bao, Meena Kumari, Anubha Mahajan, Jemma C. Hopewell, Sudha Seshadri, the METASTROKE Consortium of the ISGC, Caroline Dale, Rui Providencia E. Costa, Paul M. Ridker, Daniel I. Chasman, Alex P. Reiner, Marylyn D. Ritchie, Leslie A. Lange, Alex J. Cornish, Sara E. Dobbins, Kari Hemminki, Ben Kinnersley, Marc Sanson, Karim Labreche, Matthias Simon, Melissa Bondy, Philip Law, Helen Speedy, James Allan, Ni Li, Molly Went, Niels Weinhold, Gareth Morgan, Pieter Sonneveld, Björn Nilsson, Hartmut Goldschmidt, Amit Sud, Andreas Engert, Markus Hansson, Harry Hemingway, Folkert W. Asselbergs, Riyaz S. Patel, Brendan J. Keating, Naveed Sattar, Richard Houlston, Juan P. Casas, Aroon D. Hingorani
Publikováno v:
BMC Cardiovascular Disorders, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background We characterised the phenotypic consequence of genetic variation at the PCSK9 locus and compared findings with recent trials of pharmacological inhibitors of PCSK9. Methods Published and individual participant level data (300,000+
Externí odkaz:
https://doaj.org/article/6496ec7ef17e440a938a2e70da19e20c
Autor:
Maedeh Mohebnasab, Oskar Eriksson, Barbro Persson, Kerstin Sandholm, Camilla Mohlin, Markus Huber-Lang, Brendan J. Keating, Kristina N. Ekdahl, Bo Nilsson
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Aberrations in complement system functions have been identified as either direct or indirect pathophysiological mechanisms in many diseases and pathological conditions, such as infections, autoimmune diseases, inflammation, malignancies, and allogene
Externí odkaz:
https://doaj.org/article/b0ed3d07d90643b597d2cead0f442c2f
Autor:
Claire E. Fishman, Maede Mohebnasab, Jessica van Setten, Francesca Zanoni, Chen Wang, Silvia Deaglio, Antonio Amoroso, Lauren Callans, Teun van Gelder, Sangho Lee, Krzysztof Kiryluk, Matthew B. Lanktree, Brendan J. Keating
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
The prevalence of end-stage renal disease (ESRD) and the number of kidney transplants performed continues to rise every year, straining the procurement of deceased and living kidney allografts and health systems. Genome-wide genotyping and sequencing
Externí odkaz:
https://doaj.org/article/5d97389bad3d4eba9d91d6e3f2ef0443