Zobrazeno 1 - 10
of 117
pro vyhledávání: ''
Autor:
Martin O. Behm, Rosa I. Sanchez, Bing Lu, Kerry L. Fillgrove, Rachael Liu, Matt S. Anderson, Ka Lai Yee, Marian Iwamoto, Yun Li, Sauzanne Khalilieh, Li Fan, Joan R. Butterton, Yuexia Liang, Aditya Tatavarti
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 49(4)
Absorption, distribution, metabolism and elimination of doravirine (MK-1439), a novel non-nucleoside reverse transcriptase inhibitor, were investigated. Two clinical trials were conducted in healthy subjects: an oral single dose [
Autor:
Tomoaki Higuchi, Yuu Moriya, Liping Pan, Ronald D. Lee, Akifumi Kogame, Masami Nonaka, Yoshihiko Tagawa, Miyako Sudo
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 49(4)
The absorption, distribution, metabolism, and excretion of fasiglifam were investigated in rats, dogs, and humans. The absolute oral bioavailability of fasiglifam was high in all species (>76.0%). After oral administration of [14C]fasiglifam, the adm
Autor:
Sufeng Zhou, Ning Ou, Yuanyuan Wang, Jiye Aa, Guangji Wang, Juan Chen, Yuqing Zhao, Feng Shao, Mingxue Tao, Hongwen Zhang, Yun Liu, Lu Wang, Lijun Xie
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 49(3)
The aim of this analysis was to explore the influence of CYP3A4*1G and CYP3A5*3 polymorphisms on the pharmacokinetics of tylerdipine in healthy Chinese subjects.A total of 64 and 63 healthy Chinese subjects were included and identified as the genotyp
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 48(8)
1. The present study developed population pharmacokinetic models of arginine and glutamate in healthy Chinese volunteers. Two nonlinear mixed-effect models were developed using NONMEM® software (ICON Development Solutions, Ellicott City, MD) to desc
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 48(8)
1. Pharmacokinetics of methylnaltrexone (MNTX) were evaluated after subcutaneous administrations (s.c.) in healthy Chinese subjects. 2. In a cross-over single dose study, 12 subjects were given 0.075, 0.15, and 0.3 mg/kg of MNTX bromide injection. In
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 46(10)
1. The primary objective of this study was to evaluate the effects of quercetin on the pharmacokinetics of cefprozil. The secondary objective was to evaluate the safety of the combined use of cefprozil and quercetin. 2. An open-label, two-period, cro
Autor:
Anna Unseld, Leo Seman, Arvid Jungnik, Elsy Philip, Yanping Mao, Hans-Juergen Woerle, Sreeraj Macha, Linzhi Chen, Dale E. Sharp
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 45(6)
1. The absorption, biotransformation and excretion of empagliflozin, an SGLT2 inhibitor, were evaluated in eight healthy subjects following a single 50 mg oral dose of empagliflozin containing ∼100 µCi [(14)C]-empagliflozin. 2. Radioactivity was r
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 45(3)
1.(1S)-1-phenyl-2-(pyridin-2-yl)ethanamine (lanicemine; AZD6765) is a low-trapping N-methyl-d-aspartate (NMDA) channel blocker that has been studied as an adjunctive treatment in major depressive disorder. The metabolism and disposition of lanicemine
Autor:
Fraser Pickersgill, Mohinder S. Bathala, Hideo Takakusa, Daisuke Nakai, Mark A. Ashwell, Takashi Izumi, Tomoko Kimura, Ronald E. Savage, Taro Tokui, Emi Kamiyama, Jimbo Takeshi, Tomoe Taira, Takahiro Murai, Hamim Zahir
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 44(11)
1. The biotransformation and disposition of tivantinib in humans, dogs and rats was examined after a single oral administration of [(14)C]tivantinib. Tivantinib constituted no more than one-third of the plasma radioactivity in all species, demonstrat
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems, 31(2), 61-72. Informa Healthcare
1. The interindividual variation and enantioselectivity of the in vitro styrene oxidation by cytochrome P450 have been investigated in 20 human microsomal liver samples. Liver samples were genotyped for the CYP2E1*6 and CYP2E1*5B alleles. 2. Kinetic