Zobrazeno 1 - 4
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pro vyhledávání: '"Peter C. McMinn"'
Autor:
Peter C. McMinn, Sara Sadeghipour
Publikováno v:
Virus Research
Highlights • Here we describe the mouse virulence properties of high replication fidelity 3D polymerase variants of HEV71. • Mouse-adapted HEV71 strains were constructed to compare the virulence of the 3D polymerase variants with that of mouse-ad
Publikováno v:
Virus Research. 169:72-79
The replication of human enterovirus 71 (HEV71) in cell culture is inhibited by concentrations of guanidine that do not have an observable adverse effect on host cell metabolism. Although the HEV71 non-structural protein 2C is known to play an import
Publikováno v:
Virus Research. 167:86-96
Most human enterovirus 71 (HEV71) strains infect only primates and are unable to cause clinically apparent infection in mice. Here we describe a mouse-adapted HEV71 strain that belongs to sub-genogroup B5 with increased virulence in newborn BALB/c mi
Publikováno v:
Virus Research. 165:151-156
We selected Chinese hamster ovary (CHO) cell-adapted strains of human enterovirus 71 (HEV71) belonging to sub-genogroups B5 (HEV71-B5) and C2 (HEV71-C2) by serial passage in CHO cells at a high multiplicity of infection. During the course of CHO cell