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pro vyhledávání: ''
Autor:
Laura Lehtinen, Raija Ristamäki, Vanina D. Heuser, Annika Ålgars, Eva-Maria Birkman, Olli Carpén, Naziha Mansuri, Minnamaija Lintunen, Jari Sundström
Publikováno v:
Virchows Archiv
While host immune response is likely to be important for the prognosis of gastric cancer patients, detailed information on the T lymphocyte infiltration in different gastric cancer subtypes is lacking. Here, we studied the presence of CD3, CD8, and F
Autor:
Yi You, Jian-Hua Wu, Zhenning Wang, Ting-Ting Zhao, Zhi-Feng Miao, Xing-Yu Liu, Huimian Xu, Hao Xu, Ying-Ying Xu
Publikováno v:
Virchows Archiv. 466:525-532
The tripartite motif protein tripartite motif-containing 24 (TRIM24) is involved in human cancer progression. However, the expression pattern and biological roles of TRIM24 in human gastric cancer have not been studied. Here, we report that expressio
Publikováno v:
Virchows Archiv. 463:489-495
Heat shock protein 70 (HSP70) is a molecular chaperone which plays an important role in cellular protection against various stressful stimuli and in the regulation of cellular growth and apoptosis. This study was conducted in gastric carcinoma (GC) t
Autor:
Johannes Zenk, Stephan Schwarz-Furlan, Katharina Baader, Abbas Agaimy, Christian Rohrmeier, Tobias Ach, Gero Brockhoff, Martin Gosau, Torsten E. Reichert, Tobias Ettl, Katharina Zeitler
Publikováno v:
Virchows Archiv. 462:65-72
Hepatocyte growth factor receptor (MET) is a key driver of oncogenic transformation. Copy number gain and amplification of MET positively enhance tumour growth, invasiveness and metastasis in different cancer types. In the present study, 266 carcinom
Publikováno v:
Virchows Archiv. 460:77-87
Somatic mutations of PIK3CA and ARID1A are the most common genetic alterations observed in ovarian clear cell adenocarcinomas (CCA). In a previous report, we showed that PIK3CA gene mutations and loss of ARID1A expression occur early during the devel
Autor:
Virginie Gavric-Tanga, Jérôme Mouroux, Christelle Bonnetaud, Véronique Hofman, Virginie Lespinet-Fabre, Paul Hofman, Nicolas Venissac, Marius Ilie, Céline Coelle, Katia Havet
Publikováno v:
Virchows Archiv. 457:483-495
Specific inhibitors targeting the epidermal growth factor receptor (EGFR) can increase survival rates in certain lung adenocarcinoma patients with mutations in the EGFR gene. Although such EGFR-targeted therapies have been approved for use, there is
Autor:
Hiroshi Hashimoto, Tomoko Kurita, Naoyuki Toki, Toshinori Kawagoe, Seiji Kagami, Kimitoshi Kohno, Toru Hachisuga, Yusuke Matsuura, Atsuji Matsuyama, Hiroto Izumi
Publikováno v:
Virchows Archiv
Mitochondrial transcription factor A (mtTFA) is necessary for both transcription and maintenance of mitochondrial DNA. This study was conducted to elucidate the clinicopathologic and prognostic significance of mtTFA in patients with endometrial carci
Autor:
Florence Boissière-Michot, Jean-Christophe Sabourin, Marie-Pierre Bralet, Philippe Rochaix, Frédéric Bibeau, Michèle Radal, Laurent Arnould, Sophie Gourgou-Bourgade, Frédérique Penault-Llorca, Marc Ychou, David Azria
Publikováno v:
Virchows Archiv
Metastatic colorectal carcinomas (CRC) resistant to chemotherapy may benefit from targeting monoclonal therapy cetuximab when they express the epidermal growth factor receptor (EGFR). Because of its clinical implications, we studied EGFR expression b
Autor:
Hekmat Osman Abdel-Aziz, Hiroyuki Takahashi, Brian V. Harman, Ryouta Hori, Yasuo Takano, Chunmei Cheng, Kouichi Tsuneyama, Yoshihiro Murai, Kazuhiro Nomoto, Tomohiko Kuchina
Publikováno v:
Virchows Archiv. 447:723-730
JC virus (JCV), a ubiquitous polyoma virus that commonly infects humans, was first identified as the etiologic agent for the fetal demyelinating disease, progressive multifocal leukoencephalopathy. Recently, a number of reports have documented detect
Autor:
Koichi Tsuneyama, Kazuhiro Matsui, Shin Ishizawa, Yasuo Takano, Hiroyuki Takahashi, Chunmei Cheng
Publikováno v:
Virchows Archiv. 446:596-603
The aim of this study was to investigate the expression of c-erbB2 in non-small cell lung cancers (NSCLCs) with attention both to membranous and cytoplasmic reaction, and to try to elucidate the meaning of cytoplasmic expression of c-erbB2 in NSCLCs.