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Overexpression of c-Myb is associated with suppression of distant metastases in colorectal carcinoma
Autor:
Lenka Veverková, Jiří Jarkovský, Ivan Čapov, Petr Beneš, Jana Katolická, Jan Šmarda, Markéta Hermanová, Lucie Pekarčíková, Petr Vlček, Tichý M, Lucia Knopfová
Publikováno v:
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
The MYB gene codes for the c-Myb transcription factor maintaining proliferation of colon epithelial progenitors, thus controlling colon development and homeostasis. This gene is overexpressed in early phases of colorectal cancer (CRC) tumorigenesis.