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Autor:
Siddavaram Nagini, Abhay K. Singh, Manzar Alam, Kamdeo K. Pramanik, Prajna Mishra, Ajay Rana, Rajakishore Mishra, Ratan Kumar Dey, Aditya K. Panda, Tanushree Kashyap
Publikováno v:
Tumor Biology. 37:15253-15264
The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) and glycogen synthase kinase (GSK3) are novel tumor suppressors, and emerging evidence has suggested their active role in oral cancer pathogenesis. In the present study, 112 human
Publikováno v:
Tumor Biology. 37:13571-13579
O6-methylguanine-DNA methyltransferase (MGMT) gene promoter methylation was reported to be an independent prognostic and predictive factor in glioma patients who received temozolomide treatment. However, the predictive value of MGMT methylation was r
The suppressor of cytokine signaling 2 (SOCS2) inhibits tumor metastasis in hepatocellular carcinoma
Autor:
Jinjun Li, Fangyu Zhao, Ming Yao, Haiyang Xie, Meiling Cui, Ji Sun, Chao Ge, Tao Fang, Xin Wang, Jianjing Hou, Taoyang Chen, Hong Li, Ying Cui
Publikováno v:
Tumor Biology. 37:13521-13531
Hepatocellular carcinoma (HCC) is a common cause of cancer-related death worldwide, and its incidence continues to increase. However, the mechanism underlying the development and progression of HCC remains unknown. The suppressor of cytokine signalin
Autor:
Xu Chen, Kai Niu, Tao Li, Jianguo Sun, Zhengtang Chen, De-zhi Li, Yan-Mei Xu, Yuzhong Duan, Xing-Yun Liao, Rongxia Liao, Luping Zhang
Publikováno v:
Tumour Biology
Background Radioresistance of thoracic radiotherapy is a major bottleneck in the treatment of non-small cell lung cancer (NSCLC). Until now, there have been no effective biomarkers to predict the radiosensitivity. Purposes Based on miRNA profile scre
Autor:
Bing Shao, Huizhi Sun, Yanhui Zhang, Nan Zhao, Fang Liu, Xudong Wang, Yanlei Li, Yong Wang, Baocun Sun, Jindan An, Xiulan Zhao, Qiang Gu
Publikováno v:
Tumor Biology. 37:10965-10979
MicroRNAs (miRNAs) play vital roles in cell proliferation, differentiation and apoptosis in hepatocellular carcinoma (HCC). miR-26b has been confirmed as an important regulator in carcinogenesis and other pathological processes. miR-26b-5p is one mem
Overexpression of c-Myb is associated with suppression of distant metastases in colorectal carcinoma
Autor:
Lenka Veverková, Jiří Jarkovský, Ivan Čapov, Petr Beneš, Jana Katolická, Jan Šmarda, Markéta Hermanová, Lucie Pekarčíková, Petr Vlček, Tichý M, Lucia Knopfová
Publikováno v:
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
The MYB gene codes for the c-Myb transcription factor maintaining proliferation of colon epithelial progenitors, thus controlling colon development and homeostasis. This gene is overexpressed in early phases of colorectal cancer (CRC) tumorigenesis.
Autor:
Schapoor Hessam, Michael Sand, Stephan A. Hahn, Michael Bromba, Thilo Gambichler, Daniel Sand, Eggert Stockfleth, Falk G. Bechara
Publikováno v:
Tumor Biology. 37:10595-10608
Long noncoding RNAs (lncRNAs) are fundamental regulators of pre- and post-transcriptional gene regulation. Over 35,000 different lncRNAs have been described with some of them being involved in cancer formation. The present study was initiated to desc
Autor:
Lei Yin, Yong Qiang, Jiahui Chen, Yinda Wang, Lirong Zhu, Feiran Wang, Zhong Chen, Xian Shao, Yasu Jiang
Publikováno v:
Tumor Biology. 37:10235-10246
Recent studies have been shown that voltage-dependent anion channel 1 (VDAC1) plays an important role in carcinogenesis. However, its molecular biological function in hepatocellular carcinoma (HCC) has not been entirely clarified. This study investig
Publikováno v:
Tumor Biology. 37:9603-9613
Tumor recurrence and metastasis remain the major obstacles for the successful treatment of patients diagnosed with prostate cancer (PCa). In recent years, long non-coding RNAs (lncRNAs) have been considered as key regulators of tumor behavior. In thi
Autor:
Hao Feng, Yaping Zong, Junjun Ma, Minhua Zheng, Ai-Guo Lu, Baochi Ou, Jingkun Zhao, Puxiongzhi Wang, Jun Lu
Publikováno v:
Tumour Biology
Cadherin-12 (CDH12) is a subtype of N-cadherin family. In this study, we investigated the expression of CDH12 and the role of CDH12 in prognosis of colorectal cancer (CRC) patients. In addition, we observed the influence of CDH12 on proliferation and