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pro vyhledávání: ''
Autor:
Jee Hye Choi, Sangmyung Rhee, Sung Haeng Lee, Simon Lovestone, Lee Sael, Ah Ra Do, Jungsoo Gim, Suparna Ghosh, Sanghun Lee, Kyu Yeong Choi, SangYun Kim, Seula Keum, Juhong Park, Lindsay A. Farrer, Jang Jae Lee, Andrew J. Saykin, Gyun Jee Song, Byeong C. Kim, Kwangsik Nho, Jun Young Park, Eunae Kim, Kun Ho Lee, Immanuel Dhanasingh, Seung Hwan Moon, Hoowon Kim, Kyungtaek Park, Donghe Li, Jinyeon Jo, Tamil Iniyan Gunasekaran, Dong Soo Lee, Sungho Won, Sarang Kang, Gyungah Jun
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Translational Psychiatry
Translational Psychiatry
Established genetic risk factors for Alzheimer’s disease (AD) account for only a portion of AD heritability. The aim of this study was to identify novel associations between genetic variants and AD-specific brain atrophy. We conducted genome-wide a
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Translational Psychiatry
Translational Psychiatry
Increasing evidences supported that subjective cognitive decline (SCD) might be a potential first symptomatic manifestation of Alzheimer’s disease (AD). The rapidly growing number of SCD individuals who seek medical help and advice also makes it ur
Autor:
Irma Moilanen, Marina Evangelou, Alina Rodriguez, Ville Karhunen, Tuula Hurtig, Marjo-Riitta Järvelin, Verena Zuber, Tom Bond
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Transl Psychiatry
Karhunen, V, Bond, T, Zuber, V, Hurtig, T, Moilanen, I, Järvelin, M-R, Evangelou, M & Rodriguez, A 2021, ' The link between Attention Deficit Hyperactivity Disorder (ADHD) symptoms and obesity-related traits: Genetic and prenatal explanations ', Translational Psychiatry, vol. 11, 455 (2021) . https://doi.org/10.1038/s41398-021-01584-4
Translational Psychiatry
Transl Psychiatry
Karhunen, V, Bond, T, Zuber, V, Hurtig, T, Moilanen, I, Järvelin, M-R, Evangelou, M & Rodriguez, A 2021, ' The link between Attention Deficit Hyperactivity Disorder (ADHD) symptoms and obesity-related traits: Genetic and prenatal explanations ', Translational Psychiatry, vol. 11, 455 (2021) . https://doi.org/10.1038/s41398-021-01584-4
Translational Psychiatry
Attention-deficit/hyperactivity disorder (ADHD) often co-occurs with obesity, however, the potential causality between the traits remains unclear. We examined both genetic and prenatal evidence for causality using Mendelian Randomisation (MR) and pol
Autor:
Chen, Shi Dong, Lu, Jia Ying, Li, Hong Qi, Yang, Yu Xiang, Jiang, Jie Hui, Cui, Mei, Zuo, Chuan Tao, Tan, Lan, Dong, Qiang, Yu, Jin Tai, Weiner, Michael W., Aisen, Paul, Petersen, Ronald, Jack, Clifford R., Jagust, William, Trojanowki, John Q., Toga, Arthur W., Beckett, Laurel, Green, Robert C., Saykin, Andrew J., Morris, John C., Perrin, Richard J., Shaw, Leslie M., Carrillo, Maria, Potter, William, Barnes, Lisa, Bernard, Marie, González, Hector, Ho, Carole, Hsiao, John K., Jackson, Jonathan, Masliah, Eliezer
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Translational Psychiatry
Medical Biophysics Publications
Translational Psychiatry
Medical Biophysics Publications
A biological research framework to define Alzheimer’ disease with dichotomized biomarker measurement was proposed by National Institute on Aging–Alzheimer’s Association (NIA–AA). However, it cannot characterize the hierarchy spreading pattern
Autor:
David C. Page, Alan J. Gow, Ian J. Deary, Olivia K.L. Hamilton, M. del C. Valdés-Hernández, Paul Redmond, Simon R. Cox, Joanna M. Wardlaw, Adele M. Taylor, Lucia Ballerini, Janie Corley, Mark E. Bastin, S. Muñoz Maniega, F. Conte, Judith A. Okely
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Hamilton, O, Cox, S R, Okely, J, Conte, F, Ballerini, L, Bastin, M E, Corley, J, Taylor, A, Page, D, Gow, A, Muñoz Maniega, S, Redmond, P, Valdés Hernández, M C, Wardlaw, J M & Deary, I J 2021, ' Cerebral Small Vessel Disease Burden and Longitudinal Cognitive Decline from age 73 to 82: the Lothian Birth Cohort 1936 ', Translational Psychiatry . https://doi.org/10.1038/s41398-021-01495-4
Transl Psychiatry.
Translational Psychiatry
Hamilton, O, Cox, S R, Okely, J, Conte, F, Ballerini, L, Bastin, M E, Corley, J, Taylor, A, Page, D, Gow, A, Muñoz Maniega, S, Redmond, P, Valdés Hernández, M C, Wardlaw, J M & Deary, I J 2021, ' Cerebral Small Vessel Disease Burden and Longitudinal Cognitive Decline from age 73 to 82: the Lothian Birth Cohort 1936 ', Translational Psychiatry . https://doi.org/10.1038/s41398-021-01495-4
Transl Psychiatry.
Translational Psychiatry
Slowed processing speed is considered a hallmark feature of cognitive decline in cerebral small vessel disease (SVD); however, it is unclear whether SVD’s association with slowed processing might be due to its association with overall declining gen
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-14 (2021)
Translational Psychiatry
Translational Psychiatry
The 3q29 deletion (3q29Del) confers high risk for schizophrenia and other neurodevelopmental and psychiatric disorders. However, no single gene in this interval is definitively associated with disease, prompting the hypothesis that neuropsychiatric s
Autor:
Arianna M. Gard, Jessica D. Faul, Luke W. Hyde, Lauren Schmitz, Colter Mitchell, Erin B. Ware
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-13 (2021)
Translational Psychiatry
Translational Psychiatry
Although psychiatric phenotypes are hypothesized to organize into a two-factor internalizing–externalizing structure, few studies have evaluated the structure of psychopathology in older adults, nor explored whether genome-wide polygenic scores (PG
Autor:
Silvia Guerrera, Melania Manco, Silvia Di Vara, Lucilla Ravà, Stefano Vicari, Marta Ciofi Degli Atti, Giovanni Valeri
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Translational Psychiatry
Translational Psychiatry
The autism spectrum disorder (ASD) is an etiologically heterogeneous disorder. Dysfunctions of the intermediate metabolism have been described in some patients. We speculate these metabolic abnormalities are associated with brain insulin resistance (
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Translational Psychiatry
Translational Psychiatry
In search of the neural basis of severe trauma exposure and post-traumatic stress disorder (PTSD), a multitude of cross-sectional studies have been conducted, most of them pointing at structural deficits in the hippocampus and medial prefrontal corte
Autor:
Jordan F. Karp, James L. Kennedy, Sidney H. Kennedy, Roumen Milev, Eric J. Lenze, Daniel M. Blumberger, Farhana Islam, Daniel J. Müller, Gustavo Turecki, Benoit H. Mulsant, Etienne Sibille, Charles F. Reynolds, Victoria S. Marshe, Arun K. Tiwari, Raymond W. Lam, Malgorzata Maciukiewicz, Li Qin, Susan Rotzinger, Anne-Christin Hauschild, Benicio N. Frey, Alastair J. Flint, Jane A. Foster
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Translational Psychiatry
Translational Psychiatry
Antidepressant outcomes in older adults with depression is poor, possibly because of comorbidities such as cerebrovascular disease. Therefore, we leveraged multiple genome-wide approaches to understand the genetic architecture of antidepressant respo