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Autor:
Jordan F. Karp, James L. Kennedy, Sidney H. Kennedy, Roumen Milev, Eric J. Lenze, Daniel M. Blumberger, Farhana Islam, Daniel J. Müller, Gustavo Turecki, Benoit H. Mulsant, Etienne Sibille, Charles F. Reynolds, Victoria S. Marshe, Arun K. Tiwari, Raymond W. Lam, Malgorzata Maciukiewicz, Li Qin, Susan Rotzinger, Anne-Christin Hauschild, Benicio N. Frey, Alastair J. Flint, Jane A. Foster
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Translational Psychiatry
Translational Psychiatry
Antidepressant outcomes in older adults with depression is poor, possibly because of comorbidities such as cerebrovascular disease. Therefore, we leveraged multiple genome-wide approaches to understand the genetic architecture of antidepressant respo
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Translational Psychiatry
Translational Psychiatry
Funder: Stanley Medical Research Institute (SMRI); doi: https://doi.org/10.13039/100007123
Mental health disorders are a leading cause of disability worldwide. Challenges such as disease heterogeneity, incomplete characterization of the targets
Mental health disorders are a leading cause of disability worldwide. Challenges such as disease heterogeneity, incomplete characterization of the targets
Autor:
Laura R. Stroud, Stephanie H. Parade, Teresa E. Daniels, Audrey R. Tyrka, Lindsay Huffhines, Nicole R. Nugent
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-33 (2021)
Translational Psychiatry
Translational Psychiatry
Childhood maltreatment is a major risk factor for chronic and severe mental and physical health problems across the lifespan. Increasing evidence supports the hypothesis that maltreatment is associated with epigenetic changes that may subsequently se
Autor:
Markus J. Hofer, Samantha J. Lain, Velda X. Han, Natasha Nassar, Shekeeb S. Mohammad, Hannah F Jones, Russell C. Dale, Wendy A. Gold, Shrujna Patel, Timothy C Nielsen, Fabienne Brilot
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Translational Psychiatry
Translational Psychiatry
Inflammation is increasingly recognized as a cause or consequence of common problems of humanity including obesity, stress, depression, pollution and disease states such as autoimmunity, asthma, and infection. Maternal immune activation (MIA), trigge
Autor:
Ding-Yuan Tian, Xian-Le Bu, Pu-Yang Sun, Zhi-Qiang Xu, Yang Chen, Chen-Yang He, Yan-Jiang Wang, Hao-Lun Sun, Dong-Yu Fan, Ying-Ying Shen, Si-Han Chen, Fan Zeng, Juan Liu, Yuan Cheng, Juan Deng
Publikováno v:
Translational Psychiatry, Vol 10, Iss 1, Pp 1-11 (2020)
Translational Psychiatry
Translational Psychiatry
Deficits in the clearance of amyloid β-protein (Aβ) play a pivotal role in the pathogenesis of sporadic Alzheimer’s disease (AD). The roles of blood monocytes in the development of AD remain unclear. In this study, we sought to investigate the al
Publikováno v:
Translational Psychiatry, Vol 10, Iss 1, Pp 1-11 (2020)
Translational Psychiatry
Translational Psychiatry
First-episode psychosis (FEP) is a psychiatric disorder, characterised by positive and negative symptoms, usually emerging during adolescence and early adulthood. FEP represents an early intervention opportunity for intervention in psychosis. Redox d
Publikováno v:
Translational Psychiatry, Vol 10, Iss 1, Pp 1-13 (2020)
Translational Psychiatry
Translational Psychiatry
Continued increases in overdose deaths and recent declines in life expectancy call for need to adopt comprehensive public health approaches to the United States opioid crisis and to establish an infrastructure to avert future crises. Successfully add
Autor:
Forugh Salimi Dafsari, Frank Jessen
Publikováno v:
Translational Psychiatry, Vol 10, Iss 1, Pp 1-13 (2020)
Translational Psychiatry 10(1), 160 (2020). doi:10.1038/s41398-020-0839-1
Translational Psychiatry
Translational Psychiatry 10(1), 160 (2020). doi:10.1038/s41398-020-0839-1
Translational Psychiatry
It is broadly acknowledged that the onset of dementia in Alzheimer’s disease (AD) may be modifiable by the management of risk factors. While several recent guidelines and multidomain intervention trials on prevention of cognitive decline address li
Publikováno v:
Translational Psychiatry, Vol 10, Iss 1, Pp 1-14 (2020)
Translational Psychiatry
Translational Psychiatry
Patients with late-onset Alzheimer’s disease (LOAD) frequently manifest comorbid neuropsychiatric symptoms with depression and anxiety being most frequent, and individuals with major depressive disorder (MDD) have an increased prevalence of LOAD. T
Publikováno v:
Translational Psychiatry, Vol 10, Iss 1, Pp 1-12 (2020)
Translational Psychiatry
Translational Psychiatry
Epigenetic variation in peripheral tissues is being widely studied as a molecular biomarker of complex disease and disease-related exposures. To date, few studies have examined differences in DNA methylation associated with attention-deficit hyperact