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pro vyhledávání: ''
Autor:
David C. Page, Alan J. Gow, Ian J. Deary, Olivia K.L. Hamilton, M. del C. Valdés-Hernández, Paul Redmond, Simon R. Cox, Joanna M. Wardlaw, Adele M. Taylor, Lucia Ballerini, Janie Corley, Mark E. Bastin, S. Muñoz Maniega, F. Conte, Judith A. Okely
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Hamilton, O, Cox, S R, Okely, J, Conte, F, Ballerini, L, Bastin, M E, Corley, J, Taylor, A, Page, D, Gow, A, Muñoz Maniega, S, Redmond, P, Valdés Hernández, M C, Wardlaw, J M & Deary, I J 2021, ' Cerebral Small Vessel Disease Burden and Longitudinal Cognitive Decline from age 73 to 82: the Lothian Birth Cohort 1936 ', Translational Psychiatry . https://doi.org/10.1038/s41398-021-01495-4
Transl Psychiatry.
Translational Psychiatry
Hamilton, O, Cox, S R, Okely, J, Conte, F, Ballerini, L, Bastin, M E, Corley, J, Taylor, A, Page, D, Gow, A, Muñoz Maniega, S, Redmond, P, Valdés Hernández, M C, Wardlaw, J M & Deary, I J 2021, ' Cerebral Small Vessel Disease Burden and Longitudinal Cognitive Decline from age 73 to 82: the Lothian Birth Cohort 1936 ', Translational Psychiatry . https://doi.org/10.1038/s41398-021-01495-4
Transl Psychiatry.
Translational Psychiatry
Slowed processing speed is considered a hallmark feature of cognitive decline in cerebral small vessel disease (SVD); however, it is unclear whether SVD’s association with slowed processing might be due to its association with overall declining gen
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-14 (2021)
Translational Psychiatry
Translational Psychiatry
The 3q29 deletion (3q29Del) confers high risk for schizophrenia and other neurodevelopmental and psychiatric disorders. However, no single gene in this interval is definitively associated with disease, prompting the hypothesis that neuropsychiatric s
Autor:
Silvia Guerrera, Melania Manco, Silvia Di Vara, Lucilla Ravà, Stefano Vicari, Marta Ciofi Degli Atti, Giovanni Valeri
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Translational Psychiatry
Translational Psychiatry
The autism spectrum disorder (ASD) is an etiologically heterogeneous disorder. Dysfunctions of the intermediate metabolism have been described in some patients. We speculate these metabolic abnormalities are associated with brain insulin resistance (
Autor:
Jordan F. Karp, James L. Kennedy, Sidney H. Kennedy, Roumen Milev, Eric J. Lenze, Daniel M. Blumberger, Farhana Islam, Daniel J. Müller, Gustavo Turecki, Benoit H. Mulsant, Etienne Sibille, Charles F. Reynolds, Victoria S. Marshe, Arun K. Tiwari, Raymond W. Lam, Malgorzata Maciukiewicz, Li Qin, Susan Rotzinger, Anne-Christin Hauschild, Benicio N. Frey, Alastair J. Flint, Jane A. Foster
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Translational Psychiatry
Translational Psychiatry
Antidepressant outcomes in older adults with depression is poor, possibly because of comorbidities such as cerebrovascular disease. Therefore, we leveraged multiple genome-wide approaches to understand the genetic architecture of antidepressant respo
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Translational Psychiatry
Translational Psychiatry
Funder: Stanley Medical Research Institute (SMRI); doi: https://doi.org/10.13039/100007123
Mental health disorders are a leading cause of disability worldwide. Challenges such as disease heterogeneity, incomplete characterization of the targets
Mental health disorders are a leading cause of disability worldwide. Challenges such as disease heterogeneity, incomplete characterization of the targets
Autor:
Markus J. Hofer, Samantha J. Lain, Velda X. Han, Natasha Nassar, Shekeeb S. Mohammad, Hannah F Jones, Russell C. Dale, Wendy A. Gold, Shrujna Patel, Timothy C Nielsen, Fabienne Brilot
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Translational Psychiatry
Translational Psychiatry
Inflammation is increasingly recognized as a cause or consequence of common problems of humanity including obesity, stress, depression, pollution and disease states such as autoimmunity, asthma, and infection. Maternal immune activation (MIA), trigge
Autor:
Ding-Yuan Tian, Xian-Le Bu, Pu-Yang Sun, Zhi-Qiang Xu, Yang Chen, Chen-Yang He, Yan-Jiang Wang, Hao-Lun Sun, Dong-Yu Fan, Ying-Ying Shen, Si-Han Chen, Fan Zeng, Juan Liu, Yuan Cheng, Juan Deng
Publikováno v:
Translational Psychiatry, Vol 10, Iss 1, Pp 1-11 (2020)
Translational Psychiatry
Translational Psychiatry
Deficits in the clearance of amyloid β-protein (Aβ) play a pivotal role in the pathogenesis of sporadic Alzheimer’s disease (AD). The roles of blood monocytes in the development of AD remain unclear. In this study, we sought to investigate the al
Publikováno v:
Translational Psychiatry, Vol 10, Iss 1, Pp 1-14 (2020)
Translational Psychiatry
Translational Psychiatry
Patients with late-onset Alzheimer’s disease (LOAD) frequently manifest comorbid neuropsychiatric symptoms with depression and anxiety being most frequent, and individuals with major depressive disorder (MDD) have an increased prevalence of LOAD. T
Publikováno v:
Translational Psychiatry, Vol 8, Iss 1, Pp 1-10 (2018)
Translational Psychiatry
Translational Psychiatry
Genetic components susceptible to complex disease such as schizophrenia include a wide spectrum of variants, including common variants (CVs) and de novo mutations (DNMs). Although CVs and DNMs differ by origin, it remains elusive whether and how they
Autor:
Debra A. Fleischman, Lei Yu, Robert S. Wilson, David A. Bennett, Philip L. De Jager, Hongyu Zhao, Xiaoqing Yu, Turhan Canli
Publikováno v:
Translational Psychiatry, Vol 8, Iss 1, Pp 1-9 (2018)
Translational Psychiatry
Translational Psychiatry
Subjective social isolation, loneliness, is associated with poor mental and physical health, but the underlying molecular mechanisms are poorly understood. Here we analyzed loneliness data collected on average 5 years ante-mortem and RNA gene express