Zobrazeno 1 - 10
of 92
pro vyhledávání: ''
Autor:
David C. Yeomans, Daniel I. Jacobs, Brendan J. Tunstall, Alexander Tzabazis, Dean S. Carson, Mary R. Lee, William H. Frey, Leah R. Hanson
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021)
Translational Psychiatry
Translational Psychiatry
There is evidence of the therapeutic potential of intranasal oxytocin for the treatment of pain and various psychiatric disorders, however, there is scant evidence that oxytocin reaches the brain. We quantified the concentration and distribution patt
Autor:
Mengdan Xing, Zhe Li, Xiaojing Ye, Stephen R.J. Salton, Jin-lin Zou, Purva Bali, Yamei Tang, Wei-Jye Lin, Cheng Jiang, Noël A. Warren, Shuyu Zheng, Jingru Wu, Yan Zhao
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Translational Psychiatry
Translational Psychiatry
The release of neuropeptides from dense core vesicles (DCVs) modulates neuronal activity and plays a critical role in cognitive function and emotion. The granin family is considered a master regulator of DCV biogenesis and the release of DCV cargo mo
Autor:
Ivana Rosenzweig, Goran Sedmak, Katarina Ilić, Kristina Mlinac-Jerković, Svjetlana Kalanj-Bognar
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Translational Psychiatry
Translational Psychiatry
Synaptic glycoprotein neuroplastin is involved in synaptic plasticity and complex molecular events underlying learning and memory. Studies in mice and rats suggest that neuroplastin is essential for cognition, as it is needed for long-term potentiati
Autor:
Ya-Lin Wang, Qiong Liu, Yuanyuan Ma, Hao-ran Wu, Shanshan Zhang, Jin Yu, Honglei Xiao, Yaodong Zhang
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Translational Psychiatry
Translational Psychiatry
The purpose of the present study was to investigate whether catalpol exhibited neuroprotective effects in chronic unpredictable mild stress (CUMS) mice through oxidative stress-mediated nucleotide-binding oligomerization domain, leucine-rich repeat,
Autor:
Zheng Yu, Dongyan Ren, Bin Luo, Erkang Fei, Ziyang Liu, Baoming Li, Mingtao Xiong, Dong Lin, Changqin Zhao, Wenbing Chen
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Translational Psychiatry
Translational Psychiatry
The precise control of the nervous system function under the vitality of synapses is extremely critical. Efforts have been taken to explore the underlying cellular and molecular mechanisms for synapse formation. Cell adhesion molecules have been foun
Autor:
Pablo Dolz-Gaitón, Gefei Chen, Hugo Balleza-Tapia, Jan Johansson, André Fisahn, Yuniesky Andrade-Talavera
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-14 (2021)
Translational Psychiatry
Translational Psychiatry
Gamma and theta brain rhythms play important roles in cognition and their interaction can affect gamma oscillation features. Hippocampal theta oscillations depend on cholinergic and GABAergic input from the medial septum-diagonal band of Broca. These
Autor:
Yasmin Abergel, Joshua H. Berman, Shai Netser, Nina S. Levy, Shlomo Wagner, Andrew P. Levy, Renad Jabarin, Amir Zag
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Translational Psychiatry
Translational Psychiatry
In this study we tested the hypothesis that pharmacological modulation of glutamatergic neurotransmission could rescue behavioral deficits exhibited by mice carrying a specific mutation in the Iqsec2 gene. The IQSEC2 protein plays a key role in gluta
Autor:
Tharick A. Pascoal, Julyanna A. Peny, Elisa de Paula França Resende, Érica Leandro Marciano Vieira, Natalia M. Lyra e Silva, Isadora C. Furigo, Julia R. Clarke, Ricardo A.S. Lima-Filho, Antônio Lúcio Teixeira, Beatriz M. Longo, Pedro Rosa-Neto, Debora Hashiguchi, Jose Donato, Juliana T.S. Fortuna, Vivian S. Miya-Coreixas, Paulo Caramelli, Paul E. Fraser, Fernanda G. De Felice, Rafaella Araujo Gonçalves, Leonardo Cruz de Souza, Jose F. Abisambra, Sergio T. Ferreira
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-15 (2021)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Translational Psychiatry
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Translational Psychiatry
Alzheimer’s disease (AD) is associated with memory impairment and altered peripheral metabolism. Mounting evidence indicates that abnormal signaling in a brain-periphery metabolic axis plays a role in AD pathophysiology. The activation of pro-infla
Autor:
Nina S. Levy, Itamar Kahn, Andrew P. Levy, Eyal Bergmann, Alexandra Kavushansky, Daniela Lichtman, Nadav Cohen
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-13 (2021)
Translational Psychiatry
Translational Psychiatry
IQSEC2 is an X-linked gene which is associated with autism spectrum disorder (ASD), intellectual disability and epilepsy. IQSEC2 is a postsynaptic density protein, localized on excitatory synapses as part of the NMDA receptor complex and is suggested
Autor:
Wei-Ting Chen, Roderick N. Carter, Cheng-Yu Tsai, Kuan-Yu Wu, Yu-Ju Chen, Sin-Jhong Cheng, Guo-Jen Huang, Wei Zheng Eu
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-13 (2021)
Translational Psychiatry
Translational Psychiatry
Nerve growth factor (NGF) gene therapy has been used in clinical trials of Alzheimer’s disease. Understanding the underlying mechanisms of how NGF influences memory may help develop new strategies for treatment. Both NGF and the cholinergic system