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Autor:
Regina S. Aires, Ana D.O. Paixão, Marcelo Zaldini Hernandes, Linaldo Francisco da Silva Filho, Leucio D. Vieira, Marcelo F. Marcondes, Luiz Felipe Gomes Rebello Ferreira, Adriana K. Carmona
Publikováno v:
Toxicon. 203:30-39
NPCdc is a natriuretic peptide synthesized from the amino acid sequence of the Crotalus durissus cascavella snake venom peptide, NP2Casca. NPCdc presents hypotensive and antioxidants effects. This study aimed to investigate in vivo whether angiotensi
Publikováno v:
Toxicon. 187:223-231
Snake venom metalloproteinases (SVMPs) are an important component in viperid and crotalid venoms, and these SVMPs play important and versatile roles in the pathogenesis of snakebite envenoming. The SVMPs from elapid venoms are not well elucidated com
Autor:
Kristian A. Torres-Bonilla, Julio Alejandro Rojas-Moscoso, Rafael Stuani Floriano, Nelson Jorge da Silva, Stephen Hyslop, Edward G. Rowan, Lourdes Dias, Thalita Rocha
Publikováno v:
Toxicon. 186:58-66
Envenomation by coralsnakes (Micrurus spp.) is characterized by blockade of peripheral neurotransmission mediated by the presence of α- and β-neurotoxins. However, little is known about their cardiovascular activity. Micrurus lemniscatus lemniscatu
Autor:
César Ibarra-Alvarado, Roberto Arreguín-Espinosa, Alejandro García-Arredondo, Manuel B. Aguilar, Raymundo Ramírez, Fernando Lazcano-Pérez, Luis Cuéllar-Balleza, Luis Fernando Díaz-Peña
Publikováno v:
Toxicon. 163:12-18
Spider venoms are widely recognized as a new emerging source of potential research tools, pesticides, drug leads, and therapeutic agents. Some studies suggest that these venoms may contain interesting vasodilator compounds with potential therapeutic
Publikováno v:
Toxicon. 151:37-46
Bactridine 2 (Bact-2) is an antibacterial toxin from Tityus discrepans venom which modifies isoforms 1.2, 1.4 and 1.6 voltage-dependent sodium (Nav) channels. Bactridine-induced Na+ outflow in Yersinia enterocolitica was blocked by amiloride, suggest
Publikováno v:
Toxicon. 130:11-18
μ-conotoxins are a group of marine Conus peptides that inhibit sodium currents, so μ-conotoxins are valuable in sodium channel research and new analgesic drug discovery. Here, a novel μ-conotoxin TsIIIA was identified from a worm-hunting Conus tes
Clostridium perfringens epsilon toxin induces permanent neuronal degeneration and behavioral changes
Autor:
Winston E. Morris, Marcela Adriana Brocco, Patricia Geoghegan, Jorge Goldstein, Adriana Cangelosi, Mariano E. Fernandez-Miyakawa, Leandro M. Redondo, Fabián Loidl
Publikováno v:
Toxicon. 130:19-28
Clostridium perfringens epsilon toxin (ETX), the most potent toxin produced by this bacteria, plays a key role in the pathogenesis of enterotoxaemia in ruminants, causing brain edema and encephalomalacia. Studies of animals suffering from ETX intoxic
Autor:
Robson Q. Monteiro, Dione M. Silva, Russolina B. Zingali, Mariane Assafim, Marcos S. Ferreira, Flávia S. Frattani
Publikováno v:
Toxicon. 119:46-51
Bothrojaracin is a 27 kDa C-type lectin-like protein from Bothrops jararaca snake venom. It behaves as a potent thrombin inhibitor upon high-affinity binding to thrombin exosites. Bothrojaracin also forms a stable complex with prothrombin that can be
Autor:
Nicole A. Pereira, Bianca de Carvalho Lins Fernandes Távora, Marcelo L. Santoro, Katia C. Barbaro, Catarina Teixeira, Marta M. Antoniazzi, Simone G.S. Jared, José Pedro Prezotto-Neto, Eliana L. Faquim-Mauro, Louise F. Kimura
Publikováno v:
Toxicon. 103:65-73
This work aimed to investigate mechanisms underlying the inflammatory response caused by Potamotrygon motoro stingray venom (PmV) in mouse paws. Pre-treatment of animals with a mast cell degranulation inhibitor (cromolyn) diminished edema (62% of inh
Autor:
Izumi Shibuya, Tomohiko Kayano, Shunsuke Miyazaki, Naoki Kitamura, Norihiro Shimomura, Tsuyoshi Ichiyanagi, Tadanori Aimi
Publikováno v:
Toxicon. 81:23-31
Gymnopilins are substances produced in fruiting bodies of the hallucinogenic mushroom, Gymnopilus junonius. Although, only a few biological effects of gymnopilins on animal tissues have been reported, it is believed that gymnopilins are a key factor