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Publikováno v:
Toxicon. 38:1237-1246
Three different types of isolated nerve–synapse preparations, guinea pig ileum, rat vas deferens and toad heart, were used to investigate the physiological activity of Huwentoxin-I, a neurotoxin from the venom of the spider Selenocosmia huwena. The
Autor:
Lincoln Edwards, David A. Hessinger
Publikováno v:
Toxicon. 38:1015-1028
Portuguese Man-of-war (Physalia physalis) nematocyst venom dose-dependently stimulates calcium (45Ca(2+)) influx into L-929, GH(4)C(1), FRL, and embryonic chick heart cells. Venom-induced calcium influx is not blocked by ouabain, vanadate, nor organi
Publikováno v:
Toxicon. 38:1111-1127
This study compared the pharmacological activity of venom from male and female white-tailed spiders (L. cylindrata). In guinea-pig ileum, male L. cylindrata venom (1-10 microg/ml) caused dose-dependent contractions. The response to venom (5 microg/ml
Publikováno v:
Toxicon. 37:67-76
This study reports the effects of mannitol on nerve conduction when used as a therapeutic agent in mammals following the administration of ciguatoxin. Electrophysiological studies were performed in vivo on the rat ventral coccygeal nerve. The absolut
Publikováno v:
Toxicon. 36:759-770
Two novel peptides, named Pi4 and Pi7, were purified from the venom of the scorpion Pandinus imperator , and their primary structures were determined. These peptides have 38 amino acids residues, compacted by four disulfide bridges, instead of the no
Publikováno v:
Toxicon. 36:447-456
Mastoparan (5–30 μM), a tetradecapeptide isolated from wasp venom, caused histamine release from RBL-2H3 cells in a concentration- and time-dependent manner. Mastoparan-induced histamine release remained after removing the extracellular Ca2+, wher
Autor:
Shripad B. Deshpande, Sovan Bagchi
Publikováno v:
Toxicon. 36:309-320
The mechanism underlying the action of Indian red scorpion ( Buthus tamulus ; BT) venom on cardiac reflexes was examined in urethane anaesthetized adult albino rats of either sex. Intravenous injection of phenyldiguanide (PDG) produced reflex hypoten
Publikováno v:
Toxicon. 36:367-375
L. D. Rash, R. G. King and W. C. Hodgson. Evidence that histamine is the principal pharmacological component of venom from an Australian wolf spider ( Lycosa godeffroyi ). Toxicon 36, 367–375, 1998.—Wolf spiders are common throughout Australia an
Publikováno v:
Toxicon. 36:115-129
Previous studies showed that toxic phospholipases A2 (Pa-8 and Pa-10F) from the venom of Pseudechis australis, the Australian king brown snake, reduced acetylcholine release at mouse neuromuscular junctions and depressed motor nerve terminal action p
Publikováno v:
Toxicon. 36:63-74
The present study was designed to obtain a basic pharmacological profile of venom from the inland taipan (Oxyuranus microlepidotus). Venom (0.05-50 micrograms/ml) produced dose-dependent contractions in guinea-pig ileum, which could not be reproduced