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Autor:
Paula Pierozan, Oskar Karlsson
Publikováno v:
Toxicology Letters. 349:61-68
Per and polifluorinated substances (PFAS) are ubiquitous and persistent contaminants. Studies have indicated that fetuses and infants can be exposed to these chemicals in utero and through breastfeeding. Despite this, limited data about their effects
Publikováno v:
Toxicology Letters. 350:171-184
Recent studies have reported that melamine can accumulate in several regions of the brain including the medial prefrontal cortex (mPFC). Although melamine accumulation in the hippocampus has been verified to induce cognitive impairments, whether it c
Autor:
Milton Levin, Sylvain De Guise
Publikováno v:
Toxicology Letters. 351:155-162
Perfluorooctanoic acid (PFOA), a member of the Per- and polyfluoroalkyl substances, is a highly persistent “forever” chemicals with increasing concern for its potential health effects. However, the mechanisms of PFOA immunotoxic effects are poorl
Publikováno v:
Toxicology Letters. 345:54-60
Congenital clubfoot (CCF) is a common birth defect. Maternal smoking during pregnancy increases the risk of CCF. In previous research, we found muscle phenotypes similar to CCF in four and a half LIM domain protein 1 (FHLI) offspring mice (FHL1-/y).
Autor:
Huang Ming, Wenhu Liu, Tongxing Li, Xuemei Zhou, Zhenzhong Liu, Lili Duan, Na Chen, Jiaqi Lv, Cuihua Li, Zhuangyu Zhang, Haiyue Xie, Bo Wang, Rui Xu
Publikováno v:
Toxicology Letters. 345:67-76
Trimethyltin chloride (TMT) is a by-product in the synthesis of organotin, a plastic stabilizer. With the rapid development of industry, the occupational hazards caused by TMT cannot be ignored. TMT is a typical neurotoxicant, which mainly damages th
Publikováno v:
Toxicology Letters. 344:1-10
Methylphenidate (MPD) is used as a first-line treatment for attention-deficit/hyperactivity disorder (ADHD). The number of prescriptions for ADHD patients is increasing, suggesting that the number of fertile women using such medication might be also
Publikováno v:
Toxicology Letters. 344:34-45
ASP7962 is a small molecule inhibitor for the nerve growth factor (NGF) receptor, tropomyosin-related kinase A (TrkA). NGF contributes to the survival of sensory and sympathetic neurons through TrkA receptor activation. Gross, microscopic, and quanti
Autor:
Zhaoxia Liao, Junhua Li, Yujuan Li, Zeqi Huang, Yanhui Liu, Jing Zhang, Hui Li, Liping Miao, Ying Xu
Publikováno v:
Toxicology Letters. 341:68-79
Background General anesthetics such as sevoflurane interfere with dendritic development and synaptogenesis, resulting in cognitive impairment. The collapsin response mediator protein2 (CRMP2) plays important roles in dendritic development and synapti
Autor:
Yiyan Wang, Huitao Li, Ren-Shan Ge, Yingfen Ying, Zengqiang Li, Changchang Li, Haoni Yan, Qiqi Zhu, Xiaoheng Li
Publikováno v:
Toxicology Letters. 342:6-19
2,2',4,4'-Tetrabromodiphenyl ether (BDE47), a flame retardant, is extensively distributed in the food chain. However, whether BDE47 affects Leydig cell development during prepuberty remains unclear. BDE47 was daily gavaged to 21-day-old Sprague-Dawle
Autor:
Viktoriia Burkina, Vladimir Zlabek, Sidika Sakalli, Pham Thai Giang, Galia Zamaratskaia, Martin Krøyer Rasmussen
Publikováno v:
Burkina, V, Zamaratskaia, G, Sakalli, S, Giang, P T, Zlabek, V & Rasmussen, M K 2021, ' Tissue-specific expression and activity of cytochrome P450 1A and 3A in rainbow trout ( Oncorhynchus mykiss ) ', Toxicology Letters, vol. 341, pp. 1-10 . https://doi.org/10.1016/j.toxlet.2021.01.011
Piscine cytochrome P450 (CYP) enzymes play an important role in the metabolism of xenobiotics. Xenobiotics often act as inducers of CYP1A1 and CYP3A expression and activity in fish. We compared constitutive mRNA expression of CYP1A1, CYP3A27, and CYP