Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Robert C, James"'
Publikováno v:
Toxicology and applied pharmacology. 118(2)
Pretreatment of male ICR mice with the adrenergic agonist phenylpropanolamine (200 mg/kg, ip) resulted in a marked potentiation of hepatotoxicity produced by acetaminophen (400 mg/kg, ip). Enhanced liver necrosis with phenylpropanolamine pretreatment
Publikováno v:
Toxicology and applied pharmacology. 111(2)
Hepatic necrosis produced by carbon tetrachloride (0.02, 0.06, or 0.20 ml/kg, ip) in mice was found to be potentiated by simultaneous cotreatment with phenylpropanolamine (200 mg/kg, ip), a drug with catecholamine-like pharmacologic effects. The abil
Publikováno v:
Toxicology and Applied Pharmacology. 97:360-369
A recent study from our laboratory revealed that cotreating mice with the alpha-adrenoreceptor antagonists phentolamine and idazoxan markedly diminished bromobenzene-induced hepatotoxicity. Subsequent studies also revealed that such cotreatment does
The triphasic amphetamine lethal dose curve in mice and its possible relationship to drug metabolism
Autor:
Michael R. Franklin, Robert C. James
Publikováno v:
Toxicology and Applied Pharmacology. 44:63-73
The possible relationship between metabolism and the triphasic lethal dose curve of d -amphetamine in mice was investigated. Inhibition of hepatic oxidative metabolism with SKF 525-A (diethylaminoethyl 2,2-diphenylvalerate:HCl), Lilly 18947 (2,4-dich
Publikováno v:
Toxicology and Applied Pharmacology. 100:315-327
The pharmacokinetics of two toxicologically diverse tetrachlorobiphenyls (TCBs) were measured in mice. After dosing to apparent steady-state conditions, 2,2′,5,5′-TCB was found to have a tissue elimination half-life of between 1.64 and 2.90 days.
Autor:
Michael R. Franklin, Robert C. James
Publikováno v:
Toxicology and Applied Pharmacology. 44:75-80
The concentrations of d -amphetamine produced by doses of 20 to 60 mg/kg were determined in brain, heart, lung, and liver of adult mice and were examined for correlations with mortality. Administration of p -hydroxy-amphetamine with amphetamine did n
Autor:
Brent D. Kerger, Stephen M. Roberts, Robert C. James, Raymond D. Harbison, Jay Gandy, Thomas J. Bucci
Publikováno v:
Toxicology and Applied Pharmacology. 95:12-23
The coadministration of phentolamine, an alpha-adrenoreceptor antagonist, was found to be effective in antagonizing the hepatotoxicity produced by bromobenzene in B6C3F1 mice. Multiple doses of phentolamine, administered in dosages of 10 mg/kg, atten
Publikováno v:
Toxicology and applied pharmacology. 99(1)
The ability of morphine and other opioid analgesic drugs to diminish hepatocellular glutathione (GSH) concentrations was examined in ICR mice. When administered intraperitoneally, morphine, hydromorphone, ethylmorphine, l-alpha-acetylmethadol (LAAM),
Autor:
Jack A. Hinson, Stephen M. Roberts, Robert C. James, Raymond D. Harbison, Jay Gandy, Brent D. Kerger
Publikováno v:
Toxicology and applied pharmacology. 95(1)
A previous study has revealed that phentolamine markedly antagonizes the bromobenzene-induced hepatotoxicity and lethality in B6C3F1 mice. One potential mechanism by which phentolamine may diminish the bromobenzene-induced hepatotoxicity is by a dire