Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Pavel Vodicka"'
Publikováno v:
Toxicology and Applied Pharmacology. 210:1-8
This study describes urinary excretion of two nucleobase adducts derived from styrene 7,8-oxide (SO), i.e., 7-(2-hydroxy-1-phenylethyl)guanine (N7alphaG) and 7-(2-hydroxy-2-phenylethyl)guanine (N7betaG), as well as a formation of N7-SO-guanine adduct
Autor:
Alessio Naccarati, Aurelia Liskova, Ludmila Vodickova, Kari Hemminki, Miroslava Kuricova, Somali Sanyal, Rajesh Kumar, Eva Jahnova, Mikko Koskinen, Jana Tulinska, Maria Dusinska, Vincent Haufroid, Pavel Vodicka, Laurence J. Fuortes
Publikováno v:
Toxicology and Applied Pharmacology. 207:302-309
1-SO-adenine DNA adducts, DNA single-strand breaks (SBs), chromosomal aberrations (CAs), mutant frequency (MF) at the HPRT gene, and immune parameters (hematological and of humoral immunity) were studied in styrene-exposed human subjects and controls
Autor:
Marek Jakubowski, Ari Hirvonen, Enrico Bergamaschi, Pavel Vodicka, L Buzio, Paola Manini, Antonio Mutti, Matteo Goldoni, Roberta Andreoli
Publikováno v:
Toxicology and Applied Pharmacology. 189:160-169
Styrene is a chemical widely used in the plastic industry. The main pathway of styrene metabolism in humans occurs via the oxidation to styrene-7,8-oxide (7,8-SO). The aim of this study was the investigation of a minor metabolic route, involving the
Autor:
Paola Manini, Pavel Hlavac, Zdenek Smerhovsky, Pavel Soucek, Rajesh Kumar, Rudolf Stetina, Monika Hanova, Ludmila Vodickova, Miroslava Kuricova, Kari Hemminki, Veronika Polakova, Radka Vaclavikova, Pavel Vodicka, Alessio Naccarati
Publikováno v:
Toxicology and applied pharmacology. 248(3)
Decreased levels of single-strand breaks in DNA (SSBs), reflecting DNA damage, have previously been observed with increased styrene exposure in contrast to a dose-dependent increase in the base-excision repair capacity. To clarify further the above a